Protein Alignment PEK and eif2ak3

DIOPT Version :10

• Sequence 1: NP_649538.1
• Gene: PEK / 40653
• FlyBaseID: FBgn0037327
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: XP_005156642.3
• Gene: eif2ak3 / 559564
• ZFINID: ZDB-GENE-050414-2
• Length: 1099
• Species: Danio rerio
• Alignment Length: 1220
• Identity: 374/1220 - (30%)
• Similarity: 545/1220 - (44%)
• Gaps: 323/1220 - (26%)

  Fly    50 TAGSPRPPGLEHCVDQEERRVARRLLYISTLDGRLSALDIAKSGKLRWSVPTGPGPLISSSIHRL 114
            |..|..|.|   ..|....:..|.|:.|||||||::|||....|:.:|.:..|.|.|:|||:.:.
Zfish    80 TGDSDEPSG---DTDANFHKHRRALVIISTLDGRIAALDPLNQGRKQWDLDVGSGCLVSSSLSKP 141

  Fly   115 ELTNNGQFVRMIPSLSGGIYKF--DGDSIDPIPITAEHLLSSSAKFSDDLVISGGKETRSYGVSV 177
            |:..|..|   ||||.|.::::  |.:|::.:..:.|.||.||.:..:|.|:.|||...:||:..
Zfish   142 EIFGNKMF---IPSLDGALFQWNRDRESMEAVSFSVESLLDSSYRIGEDTVLVGGKSLTTYGLGA 203

  Fly   178 RTGQLLYECSLNGCVNSTEEGLAIDDTIREPDEEDQLEDGEQLRDEAGYIVRHDPLLDDVIIVRR 242
            .:|:|.|.||..||             .|..|||.:.|                    ||::::|
Zfish   204 YSGKLKYICSAVGC-------------SRWGDEEGEPE--------------------DVLLLQR 235

  Fly   243 QTQTVRAVESRTGVERWNFSVGQHELDLVRPSECQL--------------QPRDELELAV----- 288
            ..:|||||..|.|.|:||||||..||..|...:.:|              :.|.|.:..:
Zfish   236 TQKTVRAVRPRNGFEKWNFSVGNFELKFVPEIQSKLNFLEGEAPSGETWREVRREAQRVIQEETD 300

  Fly   289 --------------------LDVDIKVVVPEGIICAFSKSEPQTMLWKYKFDHPIVSAWNTNADD 333
                                ||:.|||.||:..:.|||......::|:::|..||.|||.... .
Zfish   301 AQTKNHAKMHPNSAHTQVEGLDLVIKVSVPDWKVMAFSTKPEGQLIWEHQFCTPIASAWLVGG-G 364

  Fly   334 ELQPIDLFSSAQWLWDQDENDT--------ELPNAPQSPPSIYLGMYDKQLYIQESIRLRQEIMD 390
            ::.||.||....:. .|.|.:|        |...|.:|  |:||||:..|||:|.|:|:.::...
Zfish   365 KVTPISLFDDTSYN-SQTETETQEDDDIMEEARGATES--SVYLGMFQGQLYLQSSVRISEKFPS 426

  Fly   391 QTKVYQQLTGDTSLM--PRIPWKP-ISASSKSLVIFRKDQEDPEMIAEGAVAQGGELVPYDDENF 452
            ::|......|||.:|  |.:.||| |.:.|::.|:...::.|..:..:          .:..|.:
Zfish   427 KSKALNGWGGDTDMMPPPTVKWKPLIHSPSRTPVLVGSEEFDKCLNND----------KFSHEEY 481

  Fly   453 AVAAQSVLNASEFVNGNGFYFYTTGDLNGPQECSTQNNPTDLPAITAPTSPTNATSEGTEATGNH 517
            :..|.|:|   ::...||:||                          |.||.........|....
Zfish   482 SNGALSIL---QYPYDNGYYF--------------------------PYSPRYRNRRDETAVSVL 517

  Fly   518 SVNDDLGFSLDDIDAPVKVVILSLWFWWKEIV-----VIAFTSAVILNIFMGQRNQRVEREYLVI 577
            ...|..|..:...|   .|::|.   |||||:     .||.|:.::...|
Zfish   518 LKKDGEGSQVRRKD---PVLLLP---WWKEILGTIFFCIAATTYIVRKFF--------------- 561

  Fly   578 ERHVPVQTAIEATEASTQALLGPVVPMQRPGNRFSFPPGQANQRTISESTTHSGEHYTSRFQSDF 642
              |.|...:.:..|:.||.         :...:|.....:..:..:::....   .|.||:.:||
Zfish   562 --HPPTTYSRQRKESETQC---------QTDTKFEADVTEPKEVVVTDMRPC---EYVSRYLTDF 612

  Fly   643 ELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPNKESSRQRVLREARTLASCEHHNIVRYFHSW 707
            |.:||||||||||||||:||:|:..||||||.|||:|.:|::|:||.:.||..||..|:|||::|
Zfish   613 EPVQCLGRGGFGVVFEARNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIIRYFNAW 677

  Fly   708 TETPPTGWQEEEDRKLL---------------AHELSTSIQIETP---DDSTMPSLTEQLKEKRQ 754
            .|:||.||||:.|::.|               ....|..:.:.||   |.|.|
Zfish   678 QESPPQGWQEDMDKRWLKDASTADWLLSSPEHMEAFSVKVPVATPSPVDSSCM------------ 730

  Fly   755 QQLLSWVSDAANSTACSHDFHLPGESSLKNIREEYDYDEEEDSLIEFRSESQSAALRAEEEDDTD 819
                  .:...:::.|..|..........::..|.|...:.|:::|......|..|...
Zfish   731 ------CAAGGDTSVCVGDQVCVEGLGPDSMMSERDSQADPDAIMEVSDSPHSFELCPP------ 783

  Fly   820 DDYEEDEEQQGDHEKRHRSSVSIDIHSASFDLK-NINYSQHQ----LVSNSFQIESVRPKSSGSD 879
                             |:....|..|:|||:. ..:..:||    .:|.|..:..|....|||
Zfish   784 -----------------RTVAHGDCTSSSFDIVFEDSGCEHQDNDSDLSGSTPVPPVCLSQSGS- 830

  Fly   880 DANDDNKARR------------KPLTLALAQNHNNNQNGSQPTPSSATILNGTVAKP---SKVYL 929
                  |.:|            :|.||:||.        |.|.|         |.:|   .||||
Zfish   831 ------KPQRSTSTGPPISLPSRPTTLSLAP--------STPCP---------VVRPLLTPKVYL 872

  Fly   930 YIQMQLCRKESLRDW-----LRDNRSETRAAHIGDIFHQIVDAVDYVHLKGLIHRDLKPSNIFFS 989
            ||||||||||:|:||     |.:.|..|:..   |||.||.:|||::|.|||:|||||||||||:
Zfish   873 YIQMQLCRKENLKDWMAQRCLPELREHTQCL---DIFLQIAEAVDFLHSKGLMHRDLKPSNIFFT 934

  Fly   990 QDGQIKIGDFGLVTDMADIPNLVAKCGDQ----------SGLPSCARHTQQVGTHLYMSPEQLLG 1044
            .|..:|:|||||||.|           ||          :.:|..||||.||||.||||||||.|
Zfish   935 MDDVVKVGDFGLVTAM-----------DQEEDDEELSTLTPMPIYARHTGQVGTKLYMSPEQLSG 988

  Fly  1045 QHYDYKVDIYSLGLIFFELHVYFSTEMERIKTLRSLRDGQYPKDFAVNYPQQYDLLQQMLSAQPE 1109
            ..|.:||||||||||.|||...|.|:|||::||..:|..|:|..|......:..:::.|||..|.
Zfish   989 NSYSHKVDIYSLGLILFELLCPFRTQMERVRTLTEVRALQFPAAFCKANILEAQMVRCMLSRVPA 1053

  Fly  1110 QRPQTKQL-KSQLRNILQLPHLLSEGQSEQAELAERARRLSRSRTFSSSS 1158
            :||:..:: ::.|...|::|                .|...|:||:|:||
Zfish  1054 ERPEASEITEAPLFQELEVP----------------CRIRQRTRTYSASS 1087

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEK	NP_649538.1	Luminal_EIF2AK3	73..401	CDD:188874	115/376 (31%)
		Protein Kinases, catalytic domain	635..1113	CDD:473864	197/530 (37%)
eif2ak3	XP_005156642.3	None