Protein Alignment PEK and Wee1

DIOPT Version :10

• Sequence 1: NP_649538.1
• Gene: PEK / 40653
• FlyBaseID: FBgn0037327
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: NP_477035.1
• Gene: Wee1 / 33965
• FlyBaseID: FBgn0011737
• Length: 609
• Species: Drosophila melanogaster
• Alignment Length: 591
• Identity: 109/591 - (18%)
• Similarity: 165/591 - (27%)
• Gaps: 304/591 - (51%)

  Fly   617 QANQRTISESTTHSGEHYTSRFQSDFELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPNKESS 681
            ||.:|.....|.      .|||:.:|..:..:|.|.|||||:..|:||...||||:...|...||
  Fly   220 QAPKRLALHDTN------ISRFKREFMQVNVIGVGEFGVVFQCVNRLDGCIYAIKKSKKPVAGSS 278

  Fly   682 -RQRVLREARTLASC-EHHNIVRYFHSWTETPPTGWQEEEDRKLLAHELSTSIQIETPDDSTMPS 744
             .:|.|.|....|.. :|.|:|||:.:|.|
  Fly   279 FEKRALNEVWAHAVLGKHDNVVRYYSAWAE----------------------------------- 308

  Fly   745 LTEQLKEKRQQQLLSWVSDAANSTACSHDFHLPGESSLKNIREEYDYDEEEDSLIEFRSESQSAA 809
                                                                             
  Fly   309 ----------------------------------------------------------------- 308

  Fly   810 LRAEEEDDTDDDYEEDEEQQGDHEKRHRSSVSIDIHSASFDLKNINYSQHQLVSNSFQIESVRPK 874
                      ||                                     |.|:.|.|       .
  Fly   309 ----------DD-------------------------------------HMLIQNEF-------C 319

  Fly   875 SSGSDDANDDNKARRKPLTLALAQNHNNNQNGSQPTPSSATILNGTVAKPSKVYLYIQMQLCRKE 939
            ..||..|.              .|:|                                   |..|
  Fly   320 DGGSLHAR--------------IQDH-----------------------------------CLGE 335

  Fly   940 SLRDWLRDNRSETRAAHIGDIFHQIVDAVDYVHLKGLIHRDLKPSNIFFS-----------QDGQ 993
                           |.:..:...:::.:.|:|...|:|.||||.|||.:           |..|
  Fly   336 ---------------AELKIVLMHVIEGLRYIHSNDLVHMDLKPENIFSTMNPNAHKLVEVQPQQ 385

  Fly   994 IKIGD--FGLVTDMADIPNLVA-KCGDQSGLPSCARHTQQVGTHLYMSPEQLLGQHYD--YKVDI 1053
            .|..|  ..:..::....|||. |.||...:.|......:.|...|: |:::|.:.|.  :|.||
  Fly   386 TKDDDGMDSVYEELRHSENLVTYKIGDLGHVTSVKEPYVEEGDCRYL-PKEILHEDYSNLFKADI 449

  Fly  1054 YSLGLIFFEL-------------HVYFSTEMERIKTLRSLRDGQYP------KDFAVNYPQQYDL 1099
            :|||:..||.             |              :||||:.|      :||       .:|
  Fly   450 FSLGITLFEAAGGGPLPKNGPEWH--------------NLRDGKVPILPSLSRDF-------NEL 493

  Fly  1100 LQQMLSAQPEQRPQTKQL-----------KSQLRNILQLP----------HLLSEGQSEQAELAE 1143
            :.||:...|::||.::.:           ||:|:..|:|.          :.|.|.:.:...|.:
  Fly   494 IAQMMHPYPDKRPTSQSIFSHPILSAVDSKSKLQLGLELTVEKRKNEILMNKLREAKKQIKLLEQ 558

  Fly  1144 RARRLS 1149
            |...|:
  Fly   559 RVNLLA 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEK	NP_649538.1	Luminal_EIF2AK3	73..401	CDD:188874
		Protein Kinases, catalytic domain	635..1113	CDD:473864	94/514 (18%)
Wee1	NP_477035.1	PTKc_Wee1	238..516	CDD:270953	92/517 (18%)