Protein Alignment PEK and Eif2ak3

DIOPT Version :10

• Sequence 1: NP_649538.1
• Gene: PEK / 40653
• FlyBaseID: FBgn0037327
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: NP_113787.1
• Gene: Eif2ak3 / 29702
• RGDID: 70884
• Length: 1108
• Species: Rattus norvegicus
• Alignment Length: 1269
• Identity: 409/1269 - (32%)
• Similarity: 597/1269 - (47%)
• Gaps: 301/1269 - (23%)

  Fly    12 RRRSLSFLQIVTLTMAGLVAFDPAQVLAGHPTTDSE--LQTAGSP----RPPGL----------- 59
            |.|:|..|.::....||:.|...|:.|.. ||:|:.  |..|.:|    |.|.:
  Rat     8 RPRALLLLFLLLGCAAGISAVARARSLLA-PTSDTAFGLGAAAAPTSAARVPAVATAEVTVEDAE 71

  Fly    60 --------------EHCVDQEERRVARRLLYISTLDGRLSALDIAKSGKLRWSVPTGPGPLISSS 110
                          |...|.|.|...|.|:.|||||||::|||....||.:|.:..|.|.|:|||
  Rat    72 ALPAASGEQESRATESDDDVELRPRGRSLVIISTLDGRIAALDAENHGKKQWDLDVGSGSLVSSS 136

  Fly   111 IHRLELTNNGQFVRMIPSLSGGIYKFDGD--SIDPIPITAEHLLSSSAKFSDDLVISGGKETRSY 173
            :.:.|:..|..   :||||.|.::::|.|  |::.:|.|.|.||.||.||.||:|:.|||...:|
  Rat   137 LSKPEVFGNKM---IIPSLDGDLFQWDRDRESMEAVPFTVESLLESSYKFGDDVVLVGGKSLTTY 198

  Fly   174 GVSVRTGQLLYECSLNGCVNSTEEGLAIDDTIREPDEEDQLEDGEQLRDEAGYIVRHDPLLDDVI 238
            |:|..:|:|.|.||..||              |..| .|::|:.|                 |::
  Rat   199 GLSAYSGKLRYICSALGC--------------RRWD-SDEMEEEE-----------------DIL 231

  Fly   239 IVRRQTQTVRAVESRTGVERWNFSVGQHELDLVRPSEC---------QLQPRDELELAVLDVD-- 292
            :::|..:|||||..|:|.|:||||||..||..:...|.         :|....|....:.||:
  Rat   232 LLQRTQKTVRAVGPRSGSEKWNFSVGHFELRYIPDMETRAGFIESTFKLGGNKEDSKIISDVEEQ 296

  Fly   293 -----IKVVVPEGIICAFSKSEPQTMLWKYKFDHPIVSAWNTNADDELQPIDLFSSAQWLWDQD- 351
                 |||.|.:..:.||||...: :.|:|:|..||.|||... |.::.||.||....:..:::
  Rat   297 DVDTVIKVSVADWKVMAFSKKGGR-LEWEYQFCTPIASAWLVR-DGKVIPISLFDDTSYTANEEV 359

  Fly   352 -ENDTELPNAPQ--SPPSIYLGMYDKQLYIQESIRLRQEIMDQTKVYQQLTGDTSL--MPRIPWK 411
             |::.::..|.:  :..|:|||||..|||:|.|:|:.::...:.|..:.:.|::::  :|.|.||
  Rat   360 LEDEEDIVEAARGATENSVYLGMYRGQLYLQSSVRVSEKFPTRPKALESVNGESAIIPLPTIKWK 424

  Fly   412 P-ISASSKSLVIFRKDQEDPEMIAEGAVAQGGELVPYDDENFAVAAQSVLNASEFVNGNGFYFYT 475
            | |.:.|::.|:...|:.|..:..:          .|..|.::..|.|:|   ::...||:|.
  Rat   425 PLIHSPSRTPVLVGSDEFDKCLSND----------KYSHEEYSNGALSIL---QYPYDNGYYL-- 474

  Fly   476 TGDLNGPQECSTQNNPTDLPAITAPTSPTNATSEGTEATGNHSVNDDLGFSLDDIDAP------- 533
                                    |..........|:.|            :..:|:|
  Rat   475 ------------------------PYYKRERNKRSTQIT------------VRFLDSPHYSKNIR 503

  Fly   534 VKVVILSLWFWWKEI-----VVIAFTSAVILNIFMGQ-RNQRVEREYLVIERHVPVQTAIEATEA 592
            .|..|| |..|||||     :.|..|:.::..:|..| ..||.|.|                |:.
  Rat   504 KKDPIL-LLHWWKEIFGTILLCIVATTFIVRRLFHPQPHRQRKESE----------------TQC 551

  Fly   593 STQALLGPVVPMQRPGNRFSFPPGQANQRTISESTTHSGEHYTSRFQSDFELMQCLGRGGFGVVF 657
            .|::....|              ...|.........|||  |.||:.:|||.:||:|||||||||
  Rat   552 QTESKYDSV--------------SADNSDNSWNDIKHSG--YVSRYLTDFEPIQCMGRGGFGVVF 600

  Fly   658 EAKNKLDENRYAIKRITLPNKESSRQRVLREARTLASCEHHNIVRYFHSWTETPPTGWQEEEDRK 722
            |||||:|:..||||||.|||:|.:|::|:||.:.||..||..|||||::|.||||..||||.|..
  Rat   601 EAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLETPPEKWQEEMDEI 665

  Fly   723 LLAHELSTSIQIETPDDSTMPSL----TEQLKEKRQQQLLSWVSDAANSTACSHDFHLP---GES 780
            .|..| ||...:.:|.....||:    .:....|.|.:::      |.|...|..|.:.   |.:
  Rat   666 WLKDE-STDWPLSSPSPMDAPSVKIRQMDPFSTKEQIEVI------APSPERSRSFSVGISCGRT 723

  Fly   781 SLKNIREEYDYDEEEDSLIEF-------RSESQSAALRAEEEDDTDDDYEEDEEQQGDHEKRHRS 838
            |         ..|.:.|.:||       .|:|:.||...::...||.|. ||....||.|
  Rat   724 S---------SSESQFSPLEFSGTDCGDNSDSEDAAHNLQDSCLTDCDM-EDGTVDGDDE----- 773

  Fly   839 SVSIDIHSASFDL---KNINYSQHQLVSNSFQIESVRPKSSGSDDANDDNKARRKPL------TL 894
                   ..||:|   :...|::.:..::|    |:..:.||.|:|:.....|...|      ..
  Rat   774 -------GHSFELCPSEASPYTRSREGTSS----SIVFEDSGCDNASSKEDPRMNRLHNGHHYVN 827

  Fly   895 ALAQ-NHNNNQNGSQ---------PTPSSATILNGTV--AKPS--KVYLYIQMQLCRKESLRDWL 945
            .|.: .|:::::.|:         ||..|......||  .:||  ||||||||||||||:|:||:
  Rat   828 KLTEFKHSSSRSSSEATLSTSPTRPTTLSLDFTRNTVDRLQPSSPKVYLYIQMQLCRKENLKDWM 892

  Fly   946 R-----DNRSETRAAHIGDIFHQIVDAVDYVHLKGLIHRDLKPSNIFFSQDGQIKIGDFGLVTDM 1005
            .     ::|......|   ||.||.:||.::|.|||:|||||||||||:.|..:|:|||||||.|
  Rat   893 NRRCSMEDREHRVCLH---IFLQIAEAVQFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAM 954

  Fly  1006 ADIPNLVAKCGDQ--------SGLPSCARHTQQVGTHLYMSPEQLLGQHYDYKVDIYSLGLIFFE 1062
                       ||        :.:|:.|.||.||||.|||||||:.|.:|.:||||:|||||.||
  Rat   955 -----------DQDEEEQTVLTPMPAYATHTGQVGTKLYMSPEQIHGNNYSHKVDIFSLGLILFE 1008

  Fly  1063 LHVYFSTEMERIKTLRSLRDGQYPKDFAVNYPQQYDLLQQMLSAQPEQRPQTKQLKSQLRNILQL 1127
            |...|||:|||::||..:|:.::|..|...|||::.::|.|||..|.:||:...
  Rat  1009 LLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPQEHMMVQDMLSPSPMERPEATD----------- 1062

  Fly  1128 PHLLSEGQSEQAELAERARRLSRSRTFSSSSEPH 1161
              ::.....|..|...:.....|||:.|||...|
  Rat  1063 --IIENAVFENLEFPGKTVLRQRSRSLSSSGTKH 1094

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEK	NP_649538.1	Luminal_EIF2AK3	73..401	CDD:188874	119/349 (34%)
		Protein Kinases, catalytic domain	635..1113	CDD:473864	209/527 (40%)
Eif2ak3	NP_113787.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	71..92		2/20 (10%)
		Luminal_EIF2AK3	99..412	CDD:188874	119/349 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	542..563		7/50 (14%)
		Protein Kinases, catalytic domain	579..>667	CDD:473864	55/87 (63%)
		Insert loop. /evidence=ECO:0000250|UniProtKB:Q9Z2B5	639..880		76/273 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	772..818		12/61 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	832..856		4/23 (17%)
		STKc_EIF2AK3_PERK	<868..1067	CDD:270950	104/225 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1080..1108		7/15 (47%)