DRSC/TRiP Functional Genomics Resources

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Protein Alignment PEK and EIF2AK1

DIOPT Version :10

Sequence 1:NP_649538.1 Gene:PEK / 40653 FlyBaseID:FBgn0037327 Length:1162 Species:Drosophila melanogaster
Sequence 2:NP_055228.2 Gene:EIF2AK1 / 27102 HGNCID:24921 Length:630 Species:Homo sapiens


Alignment Length:552 Identity:171/552 - (30%)
Similarity:254/552 - (46%) Gaps:121/552 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   632 EHYTSRFQSDFELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPNKESSR---QRVLREARTLA 693
            |..|||:.::||.:..||:||:|.|::.:||||...||||:|.:  |.:::   .:||||.:.||
Human   157 EAQTSRYLNEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILI--KGATKTVCMKVLREVKVLA 219

  Fly   694 SCEHHNIVRYFHSWTETPPTGWQEEEDRKLLAHELSTSIQIETPDDSTMPSLTEQLKEKRQQQLL 758
            ..:|.|||.|..:|.|.... .|...||          ..||.|   ::..|::| :|.|:|   
Human   220 GLQHPNIVGYHTAWIEHVHV-IQPRADR----------AAIELP---SLEVLSDQ-EEDREQ--- 266

  Fly   759 SWVSDAANSTACSHDFHLPGESSLKNIREEYDYDEEEDSLIEFRSESQSAALRAEEEDDTDDDY- 822
                       |          .:||       ||...|.|.|          ||...:.:..: 
Human   267 -----------C----------GVKN-------DESSSSSIIF----------AEPTPEKEKRFG 293

  Fly   823 EEDEEQQGDHEKRHRSSVSIDIHSASFDLKNINYSQHQLVSNSFQIES-VRPKSSGSDDANDDNK 886
            |.|.|.|.:                    |::.|:.:.::..|.::|| :..:.:|....:..:.
Human   294 ESDTENQNN--------------------KSVKYTTNLVIRESGELESTLELQENGLAGLSASSI 338

  Fly   887 ARRKPLTLALAQNHNNNQNGSQPTPSSATILN--GTVAKPSKVYLYIQMQLCRKESLRDWL---- 945
            ..::   |.|.:|.:..::.:....||...:|  |.......:.|:|||||| :.||.||:    
Human   339 VEQQ---LPLRRNSHLEESFTSTEESSEENVNFLGQTEAQYHLMLHIQMQLC-ELSLWDWIVERN 399

  Fly   946 ---RDNRSETRAAHI-----GDIFHQIVDAVDYVHLKGLIHRDLKPSNIFF-SQDGQIKIGDFGL 1001
               |:...|:...::     ..||.::|:.|.|:|..|::||||||.|||. ..|.|:|||||||
Human   400 KRGREYVDESACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGL 464

  Fly  1002 V-TDM----ADIPNLVAKCGDQSGLPSCARHTQQVGTHLYMSPEQLLGQHYDYKVDIYSLGLIFF 1061
            . ||:    .|..|...|        ....||.:|||.||.|||||.|..||.|.|:||||::..
Human   465 ACTDILQKNTDWTNRNGK--------RTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLL 521

  Fly  1062 ELHVYFSTEMERIKTLRSLRDGQYPKDFAVNYPQQYDLLQQMLSAQPEQRPQTKQ-LKSQL---- 1121
            ||...|.|||||.:.|..||.||.|:......|.|...:|.:......|||...| |:|:|    
Human   522 ELFQPFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNS 586

  Fly  1122 RNI-LQLPHLLSEGQSEQAELAERARRLSRSR 1152
            .|: |.|...:.|.:.|.|||.::...||:.:
Human   587 GNVNLTLQMKIIEQEKEIAELKKQLNLLSQDK 618

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PEKNP_649538.1 Luminal_EIF2AK3 73..401 CDD:188874
Protein Kinases, catalytic domain 635..1113 CDD:473864 155/502 (31%)
EIF2AK1NP_055228.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40
SIFI-degron. /evidence=ECO:0000269|PubMed:38297121 85..104
STKc_EIF2AK1_HRI 160..581 CDD:270951 158/510 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 259..301 17/83 (20%)
HRM 1 410..415 0/4 (0%)
HRM 2 552..557 1/4 (25%)
Blue background indicates that the domain is not in the aligned region.

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