Protein Alignment PEK and LOC11175450

DIOPT Version :10

• Sequence 1: NP_649538.1
• Gene: PEK / 40653
• FlyBaseID: FBgn0037327
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: XP_061498394.1
• Gene: LOC11175450 / 11175450
• VectorBaseID: AGAMI1_014831
• Length: 1184
• Species: Anopheles gambiae
• Alignment Length: 1197
• Identity: 502/1197 - (41%)
• Similarity: 694/1197 - (57%)
• Gaps: 216/1197 - (18%)

  Fly    21 IVTLTMAGLVAFDPAQVLAGHPTTDSELQTAGSPRPPGLEHCVDQ--EERRVARRLLYISTLDGR 83
            :||:.:.......|.|...|..|.:.            |..|.::  .:|.:...|::::||||:
Mosquito    22 VVTVALGSKGQAPPKQPDDGTATVEQ------------LPFCAEEATRQRDLNDGLVFVTTLDGK 74

  Fly    84 LSALDIAKSGKLRWSVPTGPGPLISSSIHRLELTNNGQFVRMIPSLSGGIYKFDGDSIDPIPITA 148
            :||||:...|..|||:.||||||:|||||||||||||::|||||||.|.:||||||||:|||.:|
Mosquito    75 MSALDMLNGGAERWSIQTGPGPLLSSSIHRLELTNNGKWVRMIPSLGGSLYKFDGDSIEPIPFSA 139

  Fly   149 EHLLSSSAKFSDDLVISGGKETRSYGVSVRTGQLLYECSLNGCVNSTEEG--LAIDDTIREPDEE 211
            |.||.||.||||||||||||||||||||::||||:|.|::.||.|:||..  :|.|.....|
Mosquito   140 EDLLKSSFKFSDDLVISGGKETRSYGVSMQTGQLIYVCTMQGCKNATELAMEMAADGKYGPP--- 201

  Fly   212 DQLEDGEQLRDEAGYIVRHDPLLDDVIIVRRQTQTVRAVESRTGVERWNFSVGQHELDLVRPSEC 276
               |||      ||.:   ||:.:||:::|||||||||||||||.||||||:|.||::.:...:|
Mosquito   202 ---EDG------AGTL---DPMQEDVLVIRRQTQTVRAVESRTGSERWNFSIGHHEVEKMSNEDC 254

  Fly   277 Q-LQPRDELELAVLDVDIKVVVPEGIICAFSKSEPQTMLWKYKFDHPIVSAWNTN--ADDELQPI 338
            : .:.|.|::..:||:|::|::|||:|||..||.|..::|::||:.||||||.::  .:::|..:
Mosquito   255 RGGKERREVDPVILDLDLRVIIPEGVICAVRKSAPGEIVWRHKFEVPIVSAWRSSGKTNEQLVGV 319

  Fly   339 DLFSSAQWLWDQDENDTELPNAPQSP---PSIYLGMYDKQLYIQES---IRLRQEIMDQTKVYQQ 397
            |:|....|:|:.:.:|:|..:.|  |   ||:|:||:|||||||||   |..|:|.|.|.    .
Mosquito   320 DIFDRTDWMWNGNVDDSESGDRP--PLINPSLYIGMHDKQLYIQESAAMIEEREEKMQQL----A 378

  Fly   398 LTGDTSLMPRIPWKPISASSKSLVIFRKDQEDPEMIAEGAVAQGG---ELVPYDDENFA----VA 455
            |..|.|.:|.|||||:.||              ..|| |.:..|.   :||. |||:.|    ..
Mosquito   379 LLTDESKLPAIPWKPLPAS--------------RGIA-GLLTDGNNQFQLVK-DDEDDAGESTAI 427

  Fly   456 AQSVLNASEFVNGNGFYF-YTTGDLNGPQECSTQNNPTDLPAITAPTSPTNATSEGTEATGNHSV 519
            |:|||.||.::|||||:. |.|.  ...::|....:.::        ...|:|..|.:.:.:|..
Mosquito   428 ARSVLYASNYINGNGFFLVYDTE--RDDEQCGHGEDESN--------GDNNSTKFGHDGSHDHGE 482

  Fly   520 NDDLGFSLDDIDAPVKVVILSLWFWWKEIVVIAFTSAVILNIFMGQRNQRVERE--YLVIERH-- 580
            :.|..|     ||||||:|:|:|:|||||::|:.|:|:|||:.:   ..|:|:.  .:|:||.
Mosquito   483 DMDTMF-----DAPVKVIIVSMWYWWKEILIISITTALILNMML---KLRLEKPPVMVVVERKVT 539

  Fly   581 VPVQTAIEATEASTQALLGPVVPMQRPGNRFSFPPG--QANQRTISESTTHSG-----EHYTSRF 638
            ||:.||:||.|                    .|||.  ....|:.|||::.:|     ::|||||
Mosquito   540 VPIPTAVEAVE--------------------EFPPAIRMTATRSYSESSSSNGPPALVDNYTSRF 584

  Fly   639 QSDFELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPNKESSRQRVLREARTLASCEHHNIVRY 703
            :.||:|:||||:||||||||.:||||:.||||||:.||||:.|:.||:||.:|||.|||.|||||
Mosquito   585 RDDFDLVQCLGKGGFGVVFEVRNKLDDCRYAIKRVVLPNKQESKDRVMREVKTLAHCEHQNIVRY 649

  Fly   704 FHSWTETPPTGWQEEEDRKLLAHE-LSTSIQIETPDDSTMP------------SLTEQLKEKRQQ 755
            ||:|.||||.||||..||:.:... |||||.||||.|:..|            |....:|..|.|
Mosquito   650 FHAWIETPPPGWQERHDREWIERNCLSTSIDIETPTDTCPPLPGVAASATTASSFAVGMKNSRLQ 714

  Fly   756 ----QLLSWVSD--AAN------------------STACSH-DFHLPGESSLKNIREEYDYDEEE 795
                |...|:..  |||                  |.:||. :|...||...:..|     |:|.
Mosquito   715 ASSIQSNLWMPQFPAANFSFSNGIGDGLSLKRYEQSDSCSFIEFRAEGEQDGQPAR-----DDET 774

  Fly   796 DSLIEFRSESQSAALRAEEEDDTDDDYEED------EEQQGDH--------EKRHRSSVSIDIHS 846
            .|..|..|:.:::.:::..:...:|:.|:|      :|..|..        .::|  :|:||:.|
Mosquito   775 SSSSESESDDEASEVQSNGKHRWNDEPEDDSLDIVFKEPSGSEGISSGGAVAQQH--AVAIDVSS 837

  Fly   847 ---------ASFDLK---NINYSQHQLVSNSFQIESVRPKSSGSDDANDDNKARRKPLTLALAQN 899
                     |..|.:   |:...|.|...|.|:                  |..|:||:|.|...
Mosquito   838 SPEGRSQPAAMKDARNGPNVEQQQQQQKPNPFR------------------KTHRRPLSLDLTST 884

  Fly   900 HNNNQNGSQPTPSSATILNGTVAKPSKVYLYIQMQLCRKESLRDWLRDNRSETRAAHIGDIFHQI 964
            ..::::.. ..||.......:.|:.:|:|||||||||.|:||::||..|....|...|..||.||
Mosquito   885 MRSSRDPC-TLPSGMDQSKTSSAQSNKIYLYIQMQLCHKQSLKEWLSLNGFPARRDKIVPIFEQI 948

  Fly   965 VDAVDYVHLKGLIHRDLKPSNIFFSQDGQIKIGDFGLVTDMADIPNLVAKCGDQSGLPSCA--RH 1027
            |..|:||||||||||||||||||||.||:|||||||||||.:|:     :...::.:|:..  ||
Mosquito   949 VAGVEYVHLKGLIHRDLKPSNIFFSLDGRIKIGDFGLVTDSSDL-----QYDSENNMPTMVPNRH 1008

  Fly  1028 TQQVGTHLYMSPEQLLGQHYDYKVDIYSLGLIFFELHVYFSTEMERIKTLRSLRDGQYPKDFAVN 1092
            |:||||.||||||||.|..|||||||||||||.|||.|.|.||||||.||:::|..::|.:|..:
Mosquito  1009 TRQVGTQLYMSPEQLKGLPYDYKVDIYSLGLILFELLVSFGTEMERICTLKNVRKSKFPDNFEED 1073

  Fly  1093 YPQQYDLLQQMLSAQPEQRPQTKQLKS 1119
            :..::.||..|||..|.:||.|..:|:
Mosquito  1074 HECEFKLLTLMLSEAPNKRPTTFGIKA 1100

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEK	NP_649538.1	Luminal_EIF2AK3	73..401	CDD:188874	178/338 (53%)
		Protein Kinases, catalytic domain	635..1113	CDD:473864	231/543 (43%)
LOC11175450	XP_061498394.1	None