DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12163 and Ctsll3

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_081620.2	Gene:	Ctsll3 / 70202	MGIID:	1917452	Length:	331	Species:	Mus musculus

Alignment Length:	356	Identity:	127/356 - (35%)
Similarity:	185/356 - (51%)	Gaps:	57/356 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   277 VVQA--RHTRSVE--WAEKKT-HKKHSHRFDKVDHLFYKFQVRFGRRYVSTAERQMRLRIFRQNL 336
            ||.|  .|..|::  |.|.|| |||                     .|....|.|.| .::..|.
Mouse    14 VVSAAPAHNPSLDAVWEEWKTKHKK---------------------TYNMNDEGQKR-AVWENNK 56

  Fly   337 KTIEELNANEMGSAKYG----ITEFADMTSSEYKERTGLWQRDEAKATGGSAAVVPAYH----GE 393
            |.| :|:..:....|:|    :..|.|:|::|::|....:|..:.|      .::..:.    |:
Mouse    57 KMI-DLHNEDYLKGKHGFSLEMNAFGDLTNTEFRELMTGFQGQKTK------MMMKVFQEPLLGD 114

  Fly   394 LPKEFDWRQKDAVTQVKNQGSCGSCWAFSVTGNIEGLYAVKTGELKEFSEQELLDCDTT--DSAC 456
            :||..|||....||.||:|||||||||||..|::||....|||:|...|.|.|:||..:  :..|
Mouse   115 VPKSVDWRDHGYVTPVKDQGSCGSCWAFSAVGSLEGQMFRKTGKLVPLSVQNLVDCSWSQGNQGC 179

  Fly   457 NGGLMDNAYKAIKDIGGLEYEAEYPYKAKKNQCHFNRTLSHVQVAGFVDLPKGNETAMQEWLLAN 521
            :|||.|.|::.:||.|||:....|||:|....|.:|...|...|.|||:: :.:|.|:.:.:...
Mouse   180 DGGLPDLAFQYVKDNGGLDTSVSYPYEALNGTCRYNPKNSAATVTGFVNV-QSSEDALMKAVATV 243

  Fly   522 GPISIGINA--NAMQFYRGGVSHPWKALCSKKNLDHGVLVVGYG-VSDYPNFHKTLPYWIVKNSW 583
            ||||:||:.  .:.|||:.|:.  ::..||...|||.||||||| .||      ...||:|||||
Mouse   244 GPISVGIDTKHKSFQFYKEGMY--YEPDCSSTVLDHAVLVVGYGEESD------GRKYWLVKNSW 300

  Fly   584 GPRWGEQGYYRVYRG-DNTCGVSEMATSAVL 613
            |..||..||.::.:. :|.||::..|:..|:
Mouse   301 GRDWGMNGYIKMAKDRNNNCGIASDASYPVV 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	13/60 (22%)
		Peptidase_C1A	395..611	CDD:239068	96/221 (43%)
Ctsll3	NP_081620.2	PTZ00203	7..330	CDD:185513	126/353 (36%)
		Inhibitor_I29	29..87	CDD:214853	20/80 (25%)
		Peptidase_C1	115..330	CDD:278538	96/223 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100116
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.710