Protein Alignment CtsF and CTSC

DIOPT Version :10

• Sequence 1: NP_730901.1
• Gene: CtsF / 40628
• FlyBaseID: FBgn0260462
• Length: 614
• Species: Drosophila melanogaster
• Sequence 2: NP_001805.4
• Gene: CTSC / 1075
• HGNCID: 2528
• Length: 463
• Species: Homo sapiens
• Alignment Length: 466
• Identity: 115/466 - (24%)
• Similarity: 176/466 - (37%)
• Gaps: 134/466 - (28%)

  Fly   214 GPHYKIVKVYSASRQVDSGILTRIDADLIDGSEEQHRCIV-----DI------WTKVWVRKDE-H 266
            ||..|.|.||          |.::|....|.....|..|:     :|      |...:..|:| .
Human    58 GPQEKKVVVY----------LQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGS 112

  Fly   267 EITFKCRNQPVVQARHTRSVEWA--------------------EKKTHKKHSHRFDKVDHLFYKF 311
            ::|..|...............||                    .|.:.:|:|:|..|.||.|
Human   113 KVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNF--- 174

  Fly   312 QVRFGRRYVSTAERQMRLRIFRQNLKTIEELNANEMGSAKYGITEFADMTSSEYKERTGLWQRDE 376
                                       ::.:||.:           ...|::.|.|...|...|.
Human   175 ---------------------------VKAINAIQ-----------KSWTATTYMEYETLTLGDM 201

  Fly   377 AKATGGSAAVVP--------------AYHGELPKEFDWRQK---DAVTQVKNQGSCGSCWAFSVT 424
            .:.:||.:..:|              ..|  ||..:|||..   :.|:.|:||.|||||::|:..
Human   202 IRRSGGHSRKIPRPKPAPLTAEIQQKILH--LPTSWDWRNVHGINFVSPVRNQASCGSCYSFASM 264

  Fly   425 GNIEGLYAVKTGELKE--FSEQELLDCDTTDSACNGG---LMDNAYKAIKDIGGLEYEAEYPYKA 484
            |.:|....:.|...:.  .|.||::.|......|.||   |:  |.|..:|.|.:| ||.:||..
Human   265 GMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLI--AGKYAQDFGLVE-EACFPYTG 326

  Fly   485 KKNQCHFNR------TLSHVQVAGFVDLPKG-NETAMQEWLLANGPISIGINA-NAMQFYRGGVS 541
            ..:.|....      :..:..|.||..   | ||..|:..|:.:||:::.... :....|:.|:.
Human   327 TDSPCKMKEDCFRYYSSEYHYVGGFYG---GCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIY 388

  Fly   542 H------PWKALCSKKNLDHGVLVVGYGVSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRGDN 600
            |      |:...   :..:|.||:||||......    :.|||||||||..|||.||:|:.||.:
Human   389 HHTGLRDPFNPF---ELTNHAVLLVGYGTDSASG----MDYWIVKNSWGTGWGENGYFRIRRGTD 446

  Fly   601 TCGVSEMATSA 611
            .|.:..:|.:|
Human   447 ECAIESIAVAA 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsF	NP_730901.1	Inhibitor_I29	308..365	CDD:462410	4/56 (7%)
		Peptidase_C1A	395..611	CDD:239068	75/237 (32%)
CTSC	NP_001805.4	CathepsinC_exc	25..138	CDD:462598	19/89 (21%)
		Peptidase_C1A_CathepsinC	231..460	CDD:239112	77/240 (32%)