DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12163 and Ctsq

DIOPT Version :9

Sequence 1:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_083912.2	Gene:	Ctsq / 104002	MGIID:	2137385	Length:	343	Species:	Mus musculus

Alignment Length:	347	Identity:	117/347 - (33%)
Similarity:	174/347 - (50%)	Gaps:	59/347 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   286 VEWAEKKTHKKHSHRFDKVDHLFYKFQVRFGRRYVSTAERQMRLRIFRQNLKTIEELN-ANEMGS 349
            |||      |:....|:|:               .|..|..:|..|:.:|:|.|:..| .|.:|.
Mouse    27 VEW------KEWMGSFEKL---------------YSPEEEVLRRAIWEENVKRIKLHNRENSLGK 70

  Fly   350 AKY--GITEFADMTSSEY------------KERTGLWQRDEAKATGGSAAVVPAYHGELPKEFDW 400
            ..|  |:..|||||..|:            ..|..||:|    |.|........:...|||..||
Mouse    71 NTYTMGLNGFADMTDEEFMNIVIGATLPVDNTRKSLWKR----ALGSPFPKSWYWKDALPKFVDW 131

  Fly   401 RQKDAVTQVKNQGSCGSCWAFSVTGNIEGLYAVKTGELKEFSEQELLDCDTT--DSACNGGLMDN 463
            |.:..||:|:||.:|.|||||.|||.|||....|||:|...|.|.|:||...  :..|..|...|
Mouse   132 RNEGYVTRVRNQRNCNSCWAFPVTGAIEGQMFKKTGKLIPLSVQNLVDCSRPQGNRGCRWGNTYN 196

  Fly   464 AYKAIKDIGGLEYEAEYPYKAKKNQCHFNRTLSHVQVAGFVDLPKGNETAMQEWLLANGPISIGI 528
            .::.:...||||.:|.|||:.|:..|.:|...|..::.|||.||: :|..:.:.:...|||:.||
Mouse   197 GFQYVLHNGGLEAQATYPYEGKEGLCRYNPKNSAAKITGFVVLPE-SEDVLMDAVATKGPIATGI 260

  Fly   529 N--ANAMQFYRGGVSHPWKALCSKKNLDHGVLVVGYGV----SDYPNFHKTLPYWIVKNSWGPRW 587
            :  :::.:||.|||.  ::..|: .:::|.||::|||.    :|..|      ||::|||||.||
Mouse   261 HVVSSSFRFYDGGVY--YEPNCT-SSVNHAVLIIGYGYVGNETDGNN------YWLIKNSWGRRW 316

  Fly   588 GEQGYYRVYRG-DNTCGVSEMA 608
            |..||..:.:. :|.|.::.:|
Mouse   317 GLSGYMMIAKDRNNHCAIASLA 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	17/59 (29%)
		Peptidase_C1A	395..611	CDD:239068	86/223 (39%)
Ctsq	NP_083912.2	Inhibitor_I29	29..87	CDD:214853	21/78 (27%)
Ctsq	NP_083912.2	Peptidase_C1	125..342	CDD:278538	87/224 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810