DRSC/TRiP Functional Genomics Resources

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Protein Alignment spartin and SPART

DIOPT Version :10

Sequence 1:NP_649485.1 Gene:spartin / 40582 FlyBaseID:FBgn0037265 Length:553 Species:Drosophila melanogaster
Sequence 2:NP_055902.1 Gene:SPART / 23111 HGNCID:18514 Length:666 Species:Homo sapiens


Alignment Length:650 Identity:162/650 - (24%)
Similarity:259/650 - (39%) Gaps:172/650 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 IRTAYKAAMTQVDLAVSHEEQESPGQAIVAYELALRMIEDTFGIPVGLPNKIDTVQAE-----WN 74
            ||.|||.|...|:..::.:|.....:|...|:..:..:  ..||      .|.:.::|     |.
Human    16 IREAYKKAFLFVNKGLNTDELGQKEEAKNYYKQGIGHL--LRGI------SISSKESEHTGPGWE 72

  Fly    75 DACALIQKLKSAETELRYRLKVL-RSQKQSIDDSAVEA----TEESRAEMDTKRP--------PL 126
            .|..:.||:|.....:|.||::| :....|:.:...|.    .|....:|..|.|        |.
Human    73 SARQMQQKMKETLQNVRTRLEILEKGLATSLQNDLQEVPKLYPEFPPKDMCEKLPEPQSFSSAPQ 137

  Fly   127 LAE---NPSTQYGIANA-------------SGAPKTYRELAA----------------------- 152
            .||   |.||....|.|             :.||..|...||                       
Human   138 HAEVNGNTSTPSAGAVAAPASLSLPSQSCPAEAPPAYTPQAAEGHYTVSYGTDSGEFSSVGEEFY 202

  Fly   153 ------------GLRELLAVRDAKVLLDELFRAQVKMYRIEASGSVTTISGSSTMSLVMCTVGGK 205
                        ||       ||..|:  |....|:::.:..:|.|:..|...            
Human   203 RNHSQPPPLETLGL-------DADELI--LIPNGVQIFFVNPAGEVSAPSYPG------------ 246

  Fly   206 WKYLSGIYFIQCSM-------PNEGTAGIWLYPLVPSITNCYQTEYGAFIFPDMECQQPGNAFGL 263
              ||..:.|:..|:       |.......|||||||..:...:...||::|||...|..|...|:
Human   247 --YLRIVRFLDNSLDTVLNRPPGFLQVCDWLYPLVPDRSPVLKCTAGAYMFPDTMLQAAGCFVGV 309

  Fly   264 MLTKEGQTSRTEDE---LEDLQQFFLDL-LEA-------------------------VLAGT-VV 298
            :|:.|    ..||:   .|||.:...|| |:|                         ..:|| |.
Human   310 VLSSE----LPEDDRELFEDLLRQMSDLRLQANWNRAEEENEFQIPGRTRPSSDQLKEASGTDVK 370

  Fly   299 QLKSPT------SQRAGLASDTVS------------------------GSEQVSRHIVSAADFIA 333
            ||....      .:|...|.||.|                        .||:|:.:|:|.|.:::
Human   371 QLDQGNKDVRHKGKRGKRAKDTSSEEVNLSHIVPCEPVPEEKPKELPEWSEKVAHNILSGASWVS 435

  Fly   334 SNLVRGAEKTGGFMLRSTPYIISKMTPASMDAQVPSSVQTSVEVAQKVTHAAAGMTGWIAGKVGT 398
            ..||:|||.||..:.:....:..::.|.....:|..:|...:.:|::.|..||.::.::...|.|
Human   436 WGLVKGAEITGKAIQKGASKLRERIQPEEKPVEVSPAVTKGLYIAKQATGGAAKVSQFLVDGVCT 500

  Fly   399 ASMAVGRYLAPHIQEQGSKLLQKGFGYDTSEANSTMEGAMTIAAGAVEGVSTVFDGLETSAKILG 463
            .:..||:.||||:::.||||:.:....| .:..|.::|||.:||.:|:|.|||:.|||.:||.:.
Human   501 VANCVGKELAPHVKKHGSKLVPESLKKD-KDGKSPLDGAMVVAASSVQGFSTVWQGLECAAKCIV 564

  Fly   464 SSLSENSVKIIEHKYGQQTGNLASGTFDTVGNVFVVSQNVNYITPKGIAKKMVKRTGEAVVSDYK 528
            :::|..:|:.:.:|||...|.......|:..||.|.:.|:|.|..|.:.||...:||..::.||:
Human   565 NNVSAETVQTVRYKYGYNAGEATHHAVDSAVNVGVTAYNINNIGIKAMVKKTATQTGHTLLEDYQ 629

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
spartinNP_649485.1 MIT_spastin 15..97 CDD:239142 22/86 (26%)
Senescence 325..517 CDD:462037 62/191 (32%)
SPARTNP_055902.1 MIT_spastin 16..95 CDD:239142 22/86 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 124..156 10/31 (32%)
Ubiquitin-binding region (UBR) domain. /evidence=ECO:0000269|PubMed:37443287 190..380 46/216 (21%)
LC3-interacting region (LIR), mediates interaction with MAP1LC3A AND MAP1LC3C. /evidence=ECO:0000269|PubMed:37443287 193..200 0/6 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 344..398 10/53 (19%)
Senescence 427..617 CDD:462037 62/190 (33%)
Required for localization to lipid droplets. /evidence=ECO:0000269|PubMed:37443287 431..503 17/71 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 636..666
Blue background indicates that the domain is not in the aligned region.

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