DRSC/TRiP Functional Genomics Resources

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Protein Alignment spartin and Spart

DIOPT Version :10

Sequence 1:NP_649485.1 Gene:spartin / 40582 FlyBaseID:FBgn0037265 Length:553 Species:Drosophila melanogaster
Sequence 2:NP_659144.1 Gene:Spart / 229285 MGIID:2139806 Length:671 Species:Mus musculus


Alignment Length:664 Identity:149/664 - (22%)
Similarity:257/664 - (38%) Gaps:179/664 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 IRTAYKAAMTQVDLAVSHEEQESPGQAIVAYELALRMIEDTFGIPVGLPNKIDTVQAEWNDACAL 79
            |:.||:.|...|:..::.:|.....:|...|:..:..:.....|....|......   |..|..:
Mouse    16 IKEAYEKAFMFVNKGLNTDELGQKEEAKNYYKQGIGHLLRGISIAAAEPGHTGPA---WEAARQM 77

  Fly    80 IQKLKSAETELRYRLKVLR-------------------------SQKQSIDDSAVEATEESRAEM 119
            .||:|.....:|.||::|.                         :.|:|.:..:| :|...|||:
Mouse    78 QQKMKETLQNVRTRLEILEKGLATSLRNDLQDVPKLYPEFPPKDACKKSPEQESV-STAPQRAEV 141

  Fly   120 D------------------TKRPPLLAENP------------STQYGIANAS------------G 142
            |                  ...|...||.|            :..||..:..            .
Mouse   142 DGSASAACAGPSGAPSALPVPSPSCPAEAPPAYSPQAAEGHYTVSYGTDSGEFSSVGEDFYRNRS 206

  Fly   143 APKTYRELAAGLRELLAVRDAKVLLDELFRAQVKMYRIEASGSVTTISGSSTMSLVMCTVGGKWK 207
            .|.....|.....||:.:.:.           |:::.:..:|.|:..|...              
Mouse   207 QPPPLETLGLDADELILIPNG-----------VQIFFVNPAGEVSAPSYPG-------------- 246

  Fly   208 YLSGIYFIQCSM-------PNEGTAGIWLYPLVPSITNCYQTEYGAFIFPDMECQQPGNAFGLML 265
            ||..:.|:..|:       |.......|||||||..:...:...||::|||...|..|...|::|
Mouse   247 YLRIVRFLDNSLDTVLNRPPGFLQVCDWLYPLVPDRSPVLKCTVGAYMFPDTMLQAAGCFVGVVL 311

  Fly   266 TKEGQTSRTEDE---LEDLQQFFLDL-LEA-----------------------VLAGTVVQLKS- 302
            :.|    ..||:   .|||.:...|| |:|                       ..:||.|:..| 
Mouse   312 SSE----LPEDDRELFEDLLRQMSDLRLQANWNREEDEFQIPGRSSHPSEPPKEASGTDVRQSSS 372

  Fly   303 --------------------------------------PTSQRAGLASDTVSGSEQVSRHIVSAA 329
                                                  |:|:..  :.:....||:|:.:|:|.|
Mouse   373 SGSSIDQGSKDARHKGKRGKKTKDSSEEVNLSQIVPCEPSSEEK--SKELPEWSEKVAHNILSGA 435

  Fly   330 DFIASNLVRGAEKTGGFMLRSTPYIISKMTPASMDAQVPSSVQTSVEVAQKVTHAAAGMTGWIAG 394
            .:::..||:|||.||..:.:....:..::.|.....:|..:|...:.:|::.|..||.::..:..
Mouse   436 SWVSWGLVKGAEFTGKAIQKGASKLRERIQPEEKPVEVSPAVTRGLYIAKQATGGAAKVSQLLVD 500

  Fly   395 KVGTASMAVGRYLAPHIQEQGSKLLQKGFGYDTSEANSTMEGAMTIAAGAVEGVSTVFDGLETSA 459
            .|.|.:..||:.||||:::.||||:.:....| .:..|.::|||.:||.:|:|.|||:.|||.:|
Mouse   501 GVCTVANCVGKELAPHVKKHGSKLVPESLKRD-KDGKSALDGAMVVAASSVQGFSTVWQGLECAA 564

  Fly   460 KILGSSLSENSVKIIEHKYGQQTGNLASGTFDTVGNVFVVSQNVNYITPKGIAKKMVKRTGEAVV 524
            |.:.:::|..:|:.:.:|||...|.......|:..||.:.:.|::.|..|.:.||..|:||..::
Mouse   565 KCIVNNVSAETVQTVRYKYGHNAGEATHNAVDSAINVGLTAYNIDNIGIKAMVKKTAKQTGHTLL 629

  Fly   525 SDY---KRDLRKSE 535
            .||   :|..|:|:
Mouse   630 EDYQIVERPQRESQ 643

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
spartinNP_649485.1 MIT_spastin 15..97 CDD:239142 18/81 (22%)
Senescence 325..517 CDD:462037 60/191 (31%)
SpartNP_659144.1 MIT_spastin 16..95 CDD:239142 18/81 (22%)
PRK14954 <109..>212 CDD:184918 15/103 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 110..175 12/65 (18%)
Ubiquitin-binding region (UBR) domain. /evidence=ECO:0000250|UniProtKB:Q8N0X7 190..385 43/223 (19%)
LC3-interacting region (LIR), mediates interaction with MAP1LC3A AND MAP1LC3C. /evidence=ECO:0000250|UniProtKB:Q8N0X7 193..200 0/6 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 346..421 6/76 (8%)
Senescence 431..622 CDD:462037 60/191 (31%)
Required for localization to lipid droplets. /evidence=ECO:0000250|UniProtKB:Q8N0X7 435..507 17/71 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 635..671 3/9 (33%)

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