Protein Alignment spartin and spg-20

DIOPT Version :10

• Sequence 1: NP_649485.1
• Gene: spartin / 40582
• FlyBaseID: FBgn0037265
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_491888.2
• Gene: spg-20 / 172369
• WormBaseID: WBGene00019006
• Length: 476
• Species: Caenorhabditis elegans
• Alignment Length: 554
• Identity: 109/554 - (19%)
• Similarity: 214/554 - (38%)
• Gaps: 127/554 - (22%)

  Fly    13 AGIRTAYKAAMTQVDLAVSHEEQESPGQAIVAYELALRMIEDTFGIPVGLPNKIDTVQAEWNDAC 77
            |.:...:..|...::..:.::|.......:..||..|.:|.:      |...|    .|..::..
 Worm    12 AQVDAVFSGAYASIEQGLCYDEVNDWENTLAMYEKGLNLIVE------GEKMK----NARKSEMW 66

  Fly    78 ALIQKLKSAETELRYRLKVLRSQ--KQSIDDSAVEATEESRAEMDTKRPPLLAENPSTQYGIANA 140
            .::|:.||:   :::|:.||:.:  ||.......||.|....|.:..|..|      ..:|...|
 Worm    67 KMLQESKSS---VQHRINVLKKEGPKQPTPKKIKEAEESVENEKEAIRMQL------DSFGSQEA 122

  Fly   141 SGAPKTYRELAAGLRELLAVRDAKVLLDELFRAQVKMYRIEASGSVTTISGSSTMSLVMCTVGGK 205
                                 |....|.|    .|:::.|:  |..||...:.|
 Worm   123 ---------------------DLIYFLPE----GVQLFTID--GEKTTAPTAPT----------- 149

  Fly   206 WKYLSGIYFIQCSMPNEGTA----------GIWLYPLVPSITNCYQTEYGAFIFPDMECQQPGNA 260
                 .:..::...|.:|.|          |.|.|||:.:.|...:.|:||::..:...:.|...
 Worm   150 -----SLQILRFPQPTDGGASSDTLAFMQVGPWAYPLMGAKTPVLRNEFGAYLVANPTPENPNMT 209

  Fly   261 FGLMLTKEGQTSRTEDELEDLQQFFLDLLEAVLAGTVVQLKSPTSQRAGLASDTVSGSEQVSRHI 325
            ..::|:.:.: .|..:||..:.:.|.|..|..         .|:::.:         .|:.:|..
 Worm   210 VAILLSSDIE-RRLIEELHIVLREFTDFKEQA---------EPSTELS---------KEEKNRIS 255

  Fly   326 VSAADFIASNLVRGAEKTGGFMLRSTPYIISKM---------TPASMD--AQVPSSVQTSVEVAQ 379
            .:.::|    |::|.:|....:..:|..:||::         |..:.|  .||...::.||....
 Worm   256 TTISNF----LIKGGQKIAWGVETTTVRVISRVEDNGEQYRTTLIATDKPMQVSPVIKGSVVYMH 316

  Fly   380 KVTHAAAGMTGWIAGKVGTASMAVGRYLAPHIQEQGSKLLQKGFGYDTSEANSTMEGAMTIAAGA 444
            |.|...|..|.::..|:|...:::|:.||...|.:        ||  ..::...:.|.:.|..|.
 Worm   317 KGTKTVAKCTRYLLDKIGDMGVSMGKKLADSAQRR--------FG--DGKSGGLVSGTIEILGGG 371

  Fly   445 VEGVSTVFDGLETSAKILGSSLSENSVKIIEHKYGQQTGNLASGTFDTVGNVFVVSQNVNYITPK 509
            :.||:||:..||..::.|..|::..:|:.::.|||....:.........|:..:.:..:..:.|:
 Worm   372 ITGVATVWMSLEDGSRHLCRSIANQTVQNVKLKYGDDASDTTHHALFAAGHGTLAAAQLWDLGPR 436

  Fly   510 GIAKKMVKRTGEAVVSDYKRDLRKSESHYINAGS 543
            .:|.:|.::.|..:|||.         |:...||
 Worm   437 SVAGRMARKAGIQMVSDL---------HHSRKGS 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spartin	NP_649485.1	MIT_spastin	15..97	CDD:239142	13/81 (16%)
		Senescence	325..517	CDD:462037	44/202 (22%)
spg-20	NP_491888.2	MIT_spastin	14..90	CDD:239142	15/88 (17%)
		Inp1	117..237	CDD:432685	30/163 (18%)
		Senescence	260..444	CDD:462037	44/197 (22%)