Protein Alignment eIF3a and eif3a

DIOPT Version :10

• Sequence 1: NP_649470.2
• Gene: eIF3a / 40563
• FlyBaseID: FBgn0037249
• Length: 1140
• Species: Drosophila melanogaster
• Sequence 2: NP_001096173.1
• Gene: eif3a / 100124719
• XenbaseID: XB-GENE-994394
• Length: 1391
• Species: Xenopus tropicalis
• Alignment Length: 1307
• Identity: 561/1307 - (42%)
• Similarity: 757/1307 - (57%)
• Gaps: 187/1307 - (14%)

  Fly     1 MARYTQRPENALKRANEFIEVGKPLRALDTLQEVFRNKR---WNYAYSETVIEPLMFKYLYLCVE 62
            |..|.|||||||||||||:||||...|||.|.:|.::|:   |     :.:.||:|.|||.|||:
 Frog     1 MPAYFQRPENALKRANEFLEVGKKQPALDVLYDVIKSKKHRTW-----QKIHEPIMLKYLELCVD 60

  Fly    63 LKKSHIAKEGLFQYRNMFQLVNVNSLENVIRGYLKMAEEHTEAAQAQSSAAVAVLELDDLDNIAT 127
            |:|||:|||||:||:|:.|.||:.|||:|:|.|||:|||.|||  |:.|:...||:::|||||.|
 Frog    61 LRKSHLAKEGLYQYKNICQQVNIKSLEDVVRAYLKLAEERTEA--AKESSQQMVLDIEDLDNIQT 123

  Fly   128 PESILMSAVCGEDAQDRSDRTILLPWVKFLWESYCQCLELLRVNTHCEALYHDIARMAFQFCLKY 192
            |||:|:|||.|||.|||:||.:|.||||||||||.|||:|||.|:..|.||||||:.||:|||.|
 Frog   124 PESVLLSAVSGEDTQDRTDRLLLTPWVKFLWESYRQCLDLLRNNSKVERLYHDIAQQAFKFCLLY 188

  Fly   193 NRKSEFRRLCDKLRKHLEDICKSSNQTTGVSINKVETQQLCLDTRLYLLDSAIQMELWQEAYKAI 257
            .||:|||:|||.||.||..|.:..||:|.:::|..|:|.:.|:|||..|||||.|||||||:||:
 Frog   189 TRKAEFRKLCDNLRMHLSQIQRHHNQSTAINLNNPESQSMHLETRLVQLDSAISMELWQEAFKAV 253

  Fly   258 EDIHGLMALSKKTPVPKTMANYYQKLAMVFSKAGNQLFHAAALLKLFQLTRELKKNLTKDDLQRM 322
            ||||||.|||||.|.|:.|||||.|::.||.|:||.||||:.|.:|:.|:||::||||::::|||
 Frog   254 EDIHGLFALSKKPPKPQLMANYYNKVSTVFWKSGNTLFHASTLHRLYHLSREMRKNLTQEEMQRM 318

  Fly   323 AAHVLLATLSIPLPSAHPEFDRFIEADKSPLEKAQKLAVLLGLPQPPTRVSLIREVVRLNVPQLV 387
            :..|||||||||:.....:..|.::.|...|||.::||.||||..|||||.||.::||.|:.|.|
 Frog   319 STRVLLATLSIPITPERTDIARLLDMDGIILEKQRRLATLLGLQAPPTRVGLINDMVRFNMLQYV 383

  Fly   388 SEDFRNLYNWLEVDFNPLNLCKRIQSIVDFI----ENGPENALLTPYIQSLKDVTIMRLIRQISQ 448
            ..:.:.||||||:||:||.||.|:..::|::    |..||   |..|:..|:..||:||::|::|
 Frog   384 VPEVKELYNWLEMDFHPLKLCTRVTKVLDWVKEQAEKEPE---LQQYVPQLQSNTILRLLQQVAQ 445

  Fly   449 VYESIKFQRLLQLASFCNIFELEKLLVESVRHNDMQIRIDHQKNSIYFGTDLTESQREYRPDGPA 513
            :|::|:|.||..|..|.:.|.||:.:|::.||.|:|:||||...::.||:||..|.||..|.||.
 Frog   446 LYQTIEFSRLASLVPFVDAFLLERAIVDAARHCDLQVRIDHSSRTLSFGSDLNYSTREDAPFGPF 510

  Fly   514 LQSMPSEQIRSQLVNMSTVLTRAVSIVYPNRERDQRAKLRNQMVNHYHEIKDREHQRILQRQKII 578
            ||:|||||||:||..||.||::||..:.|.....::.:.....:..|.:...:||||||.|::.|
 Frog   511 LQNMPSEQIRNQLTAMSCVLSKAVGAIKPAHVLQEKEEQHQIAITAYQKNSRKEHQRILARRQTI 575

  Fly   579 EDRKEYIEKQNNAREEEEARRQEEESRKAKLAEQKRLEQEQEERERKRHQNEIQAIREKSLKEKV 643
            |:|||.:|..|..||:||..::|.|.:|.:.||::||.||.:|||::|...|.:.|::|:::|::
 Frog   576 EERKERLENLNIQREKEEMEQKEAELQKVRKAEEERLRQEAKEREKERILQEHEQIKKKTVRERL 640

  Fly   644 QQISQTAHGKKMLSKLDEEGIKKLDAEQIAKRESEELQREAKELQSKLKSQEKKIDYFERAKRLE 708
            :||.:|..|.|....:|.|.:::||.:.|..::.|:|::|.||||.:||:|||||||||||||||
 Frog   641 EQIKKTELGAKAFKDIDIENLEELDPDFIMAKQVEQLEKEKKELQERLKNQEKKIDYFERAKRLE 705

  Fly   709 EIPLFEKYLAEKQVKDKEFWEATEKTRIENAIAERKDAVAQQERLKRMYPDRDEFLEALKKERAS 773
            ||||.:|...|:::.|.|.||..|:.||...:.||:.||..:.|:.||..|::.|:..||..|.|
 Frog   706 EIPLLKKAYEEQRINDMELWELQEEERISTLLLEREKAVEHKNRMSRMVEDKELFVSKLKASRQS 770

  Fly   774 LYVEKLKKFEAALEAERKKRLADRIIRRREERRQAFLREKEEERLRKEEEIRLAQAAEERAAAEA 838
            ||..|||:|:..|..|:..||.:|...|:||||..:.|:||||..|..|| :|.|..||:...|.
 Frog   771 LYEAKLKQFQERLAEEKAARLEERKRERKEERRVNYYRDKEEEEERLREE-QLKQEREEQEKVEN 834

  Fly   839 RRLEREAED-----EKRRAQYEKQRAKE---EEAERKIKEDR---DRLSRELAS----------- 881
            .:.|.|..|     :|...|..|:|.:|   ||.|||.:|:|   |...|:.:|
 Frog   835 EKREAEQRDYQERLKKLEEQERKKRQRELEIEERERKREEERRGGDDTFRKDSSRWGEREESGWR 899

  Fly   882 ------ERERTEKDRDTWRPRGG--DRP----SASN----------------------------- 905
                  ||::...:|| || |||  .:|    .|||
 Frog   900 RGADPDERKQVPPERD-WR-RGGPDSKPVINEDASNREEDENAALRKDEEQVSSRAFEEKVSLPD 962

  Fly   906 -----GGSSEWR--RAAPAASERNDRGGER-IERGGERIERGGERLERGGER-IE---------- 951
                 |||  ||  ...|......|||..| |:..|.|  ||.|. :||..| ||
 Frog   963 ADEEKGGS--WRDEDRGPKRGLEEDRGPRRGIDDAGPR--RGFEE-DRGPRRGIEDDRAPRRGFD 1022

  Fly   952 ----------------RGGDRDRKDNEGADSSWRVRREPDSQRAAAPK-----DSGAPQSRDDKW 995
                            ||.|.||....|.|.....||..|..|  .|:     |.|..:..||..
 Frog  1023 DDRGPRRGFDDDRGPRRGFDEDRGPRRGIDDDRGPRRGFDEDR--TPRRGFDDDRGPRRGFDDDR 1085

  Fly   996 --RRGGERD----RDFRID-GARR----DR--------DDGPRR----DR--------DDGPRRD 1029
              |||.:.|    |.|..| |.||    ||        |.||||    ||        |.||||.
 Frog  1086 GPRRGFDEDRGPRRGFEDDRGPRRGFEDDRGPRRGFEDDRGPRRGFEDDRGPRRGFEDDRGPRRG 1150

  Fly  1030 RDDERG---GFRRADGARR-TDE-------------PQR---ETGGNWR---DAPRHADRETRRP 1071
            .|::||   ||....|.|| .||             |:|   |..|:||   |.||....:.|.|
 Frog  1151 FDEDRGPRRGFEDDRGPRRGFDEDRTPRRGFDDDRGPRRGLDEDRGSWRGGDDVPRRGADDDRGP 1215

  Fly  1072 AERRDRDVRETRGDQRGSAPKEAASGGVGGNWRTAPATREEKPAAKRD-QAQEKE--NKAGDDGE 1133
            ....|.|....||:.|...|.:..:....|.||.....||:.....|| ||.|:.  ::.|:|.|
 Frog  1216 RRGADDDRGPRRGEDRDQTPWKPMAASRPGGWREREKAREDSWGPPRDSQAPEEREWSRQGEDSE 1280

  Fly  1134 WTSVKRR 1140
            ..|.:.|
 Frog  1281 KDSERDR 1287

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF3a	NP_649470.2	PINT	429..>497	CDD:214509	27/67 (40%)
		PTZ00121	<553..1128	CDD:173412	254/734 (35%)
		PRK12678	847..>1006	CDD:237171	71/267 (27%)
eif3a	NP_001096173.1	PINT	426..498	CDD:214509	30/71 (42%)
		PTZ00121	<530..858	CDD:173412	134/328 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	809..1391		146/489 (30%)
		PRK12678	911..>1144	CDD:237171	67/241 (28%)
		26 X 10 AA approximate tandem repeats of [DE]-[DE]-[DE]-R-[GATV]-[PS]-[KRW]-R-G-[AEFGIL]	973..1229		80/260 (31%)
		PRK12678	1055..>1271	CDD:237171	70/217 (32%)
		PHA03307	1184..>1376	CDD:223039	32/104 (31%)