Protein Alignment Syt14 and SYTL3

DIOPT Version :10

• Sequence 1: NP_001262249.1
• Gene: Syt14 / 40544
• FlyBaseID: FBgn0261086
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: NP_001229313.1
• Gene: SYTL3 / 94120
• HGNCID: 15587
• Length: 610
• Species: Homo sapiens
• Alignment Length: 647
• Identity: 124/647 - (19%)
• Similarity: 219/647 - (33%)
• Gaps: 193/647 - (29%)

  Fly    66 VQKITRKRRYENTSSDSEEDILRRLRWHQQH--QLGEKPGGYGLGISQANPLTAQSFNYHQAGAS 128
            :|.:.|.:..:||    ||:..|:|:.|.||  ..|.|...:                .|:....
Human    19 LQVLYRDQAVQNT----EEERTRKLKTHLQHLRWKGAKNTDW----------------EHKEKCC 63

  Fly   129 ADLQRVTVSRDPLAIAERGKVGIPSSHSECS-------SNDSMEVSV---DSHTGVLTG------ 177
            |..|:|..     .:..||.|....||..|:       ...:.:.:|   |.:..:.||
Human    64 ARCQQVLG-----FLLHRGAVCRGCSHRVCAQCRVFLRGTHAWKCTVCFEDRNVKIKTGEWFYEE 123

  Fly   178 ------------------------LSKATTTVPHPATAFRNPCGEHRAKTQALRYQHRVNVAAPP 218
                                    |||.:...|.|.....:.|.....:.|........|
Human   124 RAKKFPTGGKHETVGGQLLQSYQKLSKISVVPPTPPPVSESQCSRSPGRLQEFGQFRGFN----- 183

  Fly   219 KLDKERDNVLVVPMVNAYSINNNNNSITTSNN-----------HPSSNNNDDEPLFDTSDLRSIK 272
               |..:|:.:....:...::.:.|.:|:..:           .....:..|..:..|:  |.:.
Human   184 ---KSVENLFLSLATHVKKLSKSQNDMTSEKHLLATGPRQCVGQTERRSQSDTAVNVTT--RKVS 243

  Fly   273 SDDLLVGVDQKEPAVQRGPI--------------------------------------------- 292
            :.|:|..::|::|.....||
Human   244 APDILKPLNQEDPKCSTNPILKQQNLPSSPAPSTIFSGGFRHGSLISIDSTCTEMGNFDNANVTG 308

  Fly   293 ELELSLLYDAPMRKMTVHVMQAKNLPPLGSGQ----TTHTQVRMLMLP--SKKQKLKTKI-RSGE 350
            |:|.::.|......:.:.:...||   |..|:    ..:..|:..:||  |.:.|.||.: |:..
Human   309 EIEFAIHYCFKTHSLEICIKACKN---LAYGEEKKKKCNPYVKTYLLPDRSSQGKRKTGVQRNTV 370

  Fly   351 NPQYMESFLLHRVNPEDVNNMGLRVRLYGCERLRKERLIGEAYVSFATVDLELETN---LWLPLE 412
            :|.:.|: |.::|.|..:....|:|.::....|.:...:||..:..||.|.|..|.   .|.||.
Human   371 DPTFQET-LKYQVAPAQLVTRQLQVSVWHLGTLARRVFLGEVIIPLATWDFEDSTTQSFRWHPLR 434

  Fly   413 PR---------NTSSGLGSTSDLLSLAR-----SESAGSTSSMQHGGVSELLLGLSYNGV--TGR 461
            .:         .::..|...:.|:..:|     ....|:.....||.:..::||.....|  .|.
Human   435 AKAEKYEDSVPQSNGELTVRAKLVLPSRPRKLQEAQEGTDQPSLHGQLCLVVLGAKNLPVRPDGT 499

  Fly   462 LSVEIIKGSQFRSLSLNKAPDTYVKMVMVSSIGQEISRAKTSIRRGQPNPLFKETFAFQ-VALFQ 525
            |: ..:||    .|:|   ||            |:..|.|:.:.|.|..|.:|.:|.|. |...|
Human   500 LN-SFVKG----CLTL---PD------------QQKLRLKSPVLRKQACPQWKHSFVFSGVTPAQ 544

  Fly   526 LNDVTLMISVYAKRHMKKNE-MVGWFSLGLNSSGSEEVAHWADVCEMPKGEMLARWHVLVDS 586
            |...:|.::|:.:.....|: ::|...||  |.|...|.  .|.|.:.|    .:|..::.|
Human   545 LRQSSLELTVWDQALFGMNDRLLGGTRLG--SKGDTAVG--GDACSLSK----LQWQKVLSS 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt14	NP_001262249.1	C2A_Synaptotagmin-14_16	291..413	CDD:176035	35/176 (20%)
		C2B_Synaptotagmin-14_16	446..584	CDD:176053	36/141 (26%)
SYTL3	NP_001229313.1	PHD_SF	8..123	CDD:473978	27/128 (21%)
		FYVE_Slp3	60..108	CDD:277304	10/52 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	219..239		1/19 (5%)
		C2A_SLP-3	307..434	CDD:176038	32/130 (25%)
		C2B_SLP_1-2-3-4	448..610	CDD:175987	43/179 (24%)