Protein Alignment Syt14 and SYT12

DIOPT Version :10

• Sequence 1: NP_001262249.1
• Gene: Syt14 / 40544
• FlyBaseID: FBgn0261086
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: XP_011543648.1
• Gene: SYT12 / 91683
• HGNCID: 18381
• Length: 456
• Species: Homo sapiens
• Alignment Length: 500
• Identity: 114/500 - (22%)
• Similarity: 184/500 - (36%)
• Gaps: 83/500 - (16%)

  Fly   116 TAQSFNYHQAGASADLQRVTVSRDPLAIAERGKVGIPSSH-SECSSNDSMEVSVDSHTGVLTGLS 179
            |..:..:|..|.....:...|....:..|:...|.:...| |...|....||.|.: .|.|..|.
Human     5 TQTNIIFHSPGNEMKTKAPPVGEVTVTAADIMAVDVAEYHLSVIKSPPGWEVGVYA-AGALALLG 68

  Fly   180 KATTTV-------------PHPATAFR-------NPCGEHRAKTQALRYQHRVNVAAPPKLDKER 224
            .|..::             |.|...:|       ..|.|.|.|........|.:...||.
Human    69 IAAVSLWKLWTSGSFPSPSPFPNYDYRYLQQKYGESCAEAREKRVPAWNAQRASTRGPPS----- 128

  Fly   225 DNVLVVPMVNAYSINNNNNSITTSNNHPSSNNNDDEPLFDTSDLRSIKSDDLLVGVDQKEPAVQR 289
                   ...:.||.:...||  |...|......:..|.....||..:|.|.|..:........:
Human   129 -------RKGSLSIEDTFESI--SELGPLELMGRELDLAPYGTLRKSQSADSLNSISSVSNTFGQ 184

  Fly   290 ----GPIELELSLLYDAPMRKMTVHVMQAKNLPPLGSGQTTHTQVRMLMLPSKKQKLKTKIRSGE 350
                |  ::|:|:.||.....:.|.|||.|:|............:|:.:||.::....::|:...
Human   185 DFTLG--QVEVSMEYDTASHTLNVAVMQGKDLLEREEASFESCFMRVSLLPDEQIVGISRIQRNA 247

  Fly   351 NPQYMESFLLHRVNPEDVNNMGLRVRLYGCERLRKERLIGEAYVSFATVDLELETNLWLPLEPRN 415
            ...:.:......::|..:....||..::|.:.       .|..||...|:|:|.. |.|||:|
Human   248 YSIFFDEKFSIPLDPTALEEKSLRFSVFGIDE-------DERNVSTGVVELKLSV-LDLPLQP-- 302

  Fly   416 TSSGLGSTSDLLSLARSESAGSTSSMQHGGVSELLLGLSYNGVTGRLSVEIIKGSQFRSLSLNKA 480
                   .|..|.|.....|..       .|.|:||.|||.....||:|.::|.......:....
Human   303 -------FSGWLYLQDQNKAAD-------AVGEILLSLSYLPTAERLTVVVVKAKNLIWTNDKTT 353

  Fly   481 PDTYVKMVMVSSIGQEISRAKTSIRRGQPNPLFKETFAFQVALFQLNDVTLMISVYAKRHMKKNE 545
            .|.:||:.::.. |:::|:.||:::|..|||:|.|...|.|....|.|::|.::|.......:.:
Human   354 ADPFVKVYLLQD-GRKMSKKKTAVKRDDPNPVFNEAMIFSVPAIVLQDLSLRVTVAESSSDGRGD 417

  Fly   546 MVGWFSLGLNSSGSEEVAHWADVCEMPKGEMLA-------RWHVL 583
            .||...:|.::||. ...||        .:|||       .||.:
Human   418 NVGHVIIGPSASGM-GTTHW--------NQMLATLRRPVSMWHAV 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt14	NP_001262249.1	C2A_Synaptotagmin-14_16	291..413	CDD:176035	28/121 (23%)
		C2B_Synaptotagmin-14_16	446..584	CDD:176053	42/144 (29%)
SYT12	XP_011543648.1	C2	187..298	CDD:472691	26/120 (22%)
		C2B_Synaptotagmin-12	319..454	CDD:176051	42/144 (29%)