Protein Alignment Syt14 and SYT7

DIOPT Version :10

• Sequence 1: NP_001262249.1
• Gene: Syt14 / 40544
• FlyBaseID: FBgn0261086
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: XP_011543637.1
• Gene: SYT7 / 9066
• HGNCID: 11514
• Length: 692
• Species: Homo sapiens
• Alignment Length: 537
• Identity: 131/537 - (24%)
• Similarity: 210/537 - (39%)
• Gaps: 101/537 - (18%)

  Fly    67 QKITRKRRYENTSSDSEEDILRRLRWHQQHQLGEKPGGYGLGISQANPLTAQSFNYHQAGASADL 131
            |.:::.:|....|..:....|.:|:.|.....|..|..||.|  ||...|:....|..||..:..
Human   235 QPLSQHQRGRQPSQPTTSQSLGQLQAHMASAPGPNPRAYGRG--QARQGTSAGSKYRAAGGRSRS 297

  Fly   132 QRVTVSRDPLAIAERGKVGIPSSHSECSSNDSMEVSVDSHTGVLT---GLSKAT--TTVP---HP 188
            ...:.......|..||.              .|:..::....||:   |||:..  ..:|   :|
Human   298 NPGSWDHVVGQIRNRGL--------------DMKSFLEGRMVVLSLVLGLSEQDDFANIPDLQNP 348

  Fly   189 ATAFRNPCGEHRAKTQALRYQHRVNVAAPPKLDKERDNVLVVPMVNAYSINNNNNSITTSNNHPS 253
            .|                  |...|.....:|......|...|:                   |.
Human   349 GT------------------QQNQNAQGDKRLPAGGKAVNTAPV-------------------PG 376

  Fly   254 SNNNDD-----EPLFDTSDL-RSIKSDDLLVGVDQKEPAVQRGPI-----ELELSLLYDAPMRKM 307
            ...:|:     ||....||| .|:.|:.|::....:|.....|..     .::.|:.|:.....:
Human   377 QTPHDESDRRTEPRSSVSDLVNSLTSEMLMLSPGSEEDEAHEGCSRENLGRIQFSVGYNFQESTL 441

  Fly   308 TVHVMQAKNLPPLGSGQTTHTQVRMLMLPSKKQKLKTKI-RSGENPQYMESFLLHRVNPEDVNNM 371
            ||.:|:|:.||......|:...|::.:||.||.||:||: |...||.:.|:||......|.|...
Human   442 TVKIMKAQELPAKDFSGTSDPFVKIYLLPDKKHKLETKVKRKNLNPHWNETFLFEGFPYEKVVQR 506

  Fly   372 GLRVRLYGCERLRKERLIGEAYVSFATVDLELETNLWLPLEPRNTSSGLGSTSDLLSLARSESAG 436
            .|.:::...:|..:...|||..:....|||......|..|:|  .|.|.||.
Human   507 ILYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQTFWKDLKP--CSDGSGSR------------- 556

  Fly   437 STSSMQHGGVSELLLGLSYNGVTGRLSVEIIKGSQFRSLSLNKAPDTYVKMVMVSSIGQEISRAK 501
                      .||||.|.||.....:.|.|||....:::.:....|.|||:.::.. .:.:.:.|
Human   557 ----------GELLLSLCYNPSANSIIVNIIKARNLKAMDIGGTSDPYVKVWLMYK-DKRVEKKK 610

  Fly   502 TSIRRGQPNPLFKETFAFQVALFQLNDVTLMISVYAKRHMKKNEMVGWFSLGLNSSGSEEVAHWA 566
            |...:...||:|.|:|||.:...:|.:.|::|:|..|..:.:|:::|...|.. .||..||.||.
Human   611 TVTMKRNLNPIFNESFAFDIPTEKLRETTIIITVMDKDKLSRNDVIGKIYLSW-KSGPGEVKHWK 674

  Fly   567 DVCEMPKGEMLARWHVL 583
            |:...|: :.:|:||.|
Human   675 DMIARPR-QPVAQWHQL 690

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt14	NP_001262249.1	C2A_Synaptotagmin-14_16	291..413	CDD:176035	36/127 (28%)
		C2B_Synaptotagmin-14_16	446..584	CDD:176053	44/138 (32%)
SYT7	XP_011543637.1	PHA03307	<149..>316	CDD:223039	20/96 (21%)
		C2A_Synaptotagmin-7	424..548	CDD:176032	36/123 (29%)
		C2B_Synaptotagmin-7	556..691	CDD:176050	44/161 (27%)