Protein Alignment Syt14 and Tc2n

DIOPT Version :10

• Sequence 1: NP_001262249.1
• Gene: Syt14 / 40544
• FlyBaseID: FBgn0261086
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: NP_083200.1
• Gene: Tc2n / 74413
• MGIID: 1921663
• Length: 489
• Species: Mus musculus
• Alignment Length: 528
• Identity: 102/528 - (19%)
• Similarity: 195/528 - (36%)
• Gaps: 138/528 - (26%)

  Fly   132 QRVTVSRD--PLAIAERGKVGIPSSHS-------ECSSN--------DSMEV------------- 166
            |:.:|.||  ..|.:.:..:|||...|       .|:.:        |..||
Mouse    21 QKFSVDRDFKASASSSQNTIGIPPLTSVLVKPQVGCNEDYLLSKLPCDGKEVQFVVPRFKLSYIQ 85

  Fly   167 ----SVDSHTGVLTGLSKAT---------TTVPH-PATAFRNPCGEHRAKTQALRYQHRVNVAAP 217
                .:.||...|.|.::|:         ::..| |:....|||         ..|||     ..
Mouse    86 PRTQGIPSHLDELEGSARASFGDQKTELCSSFYHGPSYDVYNPC---------YMYQH-----FS 136

  Fly   218 PKLDKERDNVLVVPMVNAYSINNNNNSITTSNNHPSSNNNDDEPLFDTSDLRSIKSDDLLVGVDQ 282
            |.|.:.     .:|......:..:...:.||....||..:.......||..|.|:..|....|..
Mouse   137 PDLSRR-----FLPHCETKQLYGSVCDLRTSKLPGSSGLSKSMLDLTTSSQRFIQRHDSFSSVPS 196

  Fly   283 KEPA------------------VQRGPIELELSLLYDAPMRKMTVHVMQAKNLP-PLGSGQTTHT 328
            ...:                  .:|....|.:.|.|::...::.:.|:|.:::. |...|.|...
Mouse   197 SSSSRKNSQGSNRSLDTITLSGDERDLGRLNVKLFYNSSAEQIWITVLQCRDISWPSSYGDTPTI 261

  Fly   329 QVRMLMLPSKKQKLKTKIRSGENP-QYMESFLLHRVNPEDVNNMGLRVRLYGCERLR-------- 384
            .::.::..||....|:..:.|.|. ::||:|:             ..::|...:.:|
Mouse   262 SIKGILTLSKPVHFKSSAKEGSNAIEFMETFV-------------FAIKLQNLQAVRLAFKIQTQ 313

  Fly   385 --KERLIGEAYVSFATVDL-ELETNLWLPLEPRNTSSGLGSTSDLLSLARSESAGSTSSMQHGGV 446
              |::.|||..:|..|:.. |:|.:|.: :.|..           :|:.:
Mouse   314 TPKKKTIGECSLSLRTLSTQEMEYSLEI-IAPSK-----------ISVCQ--------------- 351

  Fly   447 SELLLGLSYNGVTGRLSVEIIKGSQFRSLSLNKAPDTYVKMVMVSSIGQEISRAKTSIRRGQPNP 511
            :||.||..:..|..|:.::|::.....|.|.......:||:.|.|| |:.|.:.||.:.:.....
Mouse   352 AELELGTCFQAVNSRIQLQILEAQYLPSSSTPLTLSFFVKVGMFSS-GELIYKKKTRLLKASSGR 415

  Fly   512 L-FKETFAFQVALFQLNDVTLMISVYAKRHMKKNEMVGWFSLGLNSSGSEEVAHWADVCEMPKGE 575
            : :.||..|.:...: .::..:|.:|::..:::...||...:..:|:..|.|..|.:....|: :
Mouse   416 VKWGETMIFPLIQTE-KEIVFLIKLYSRSSVRRKHFVGQLWISEDSNNIEAVNQWKETITNPE-K 478

  Fly   576 MLARWHVL 583
            ::.:||.|
Mouse   479 VVIKWHKL 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt14	NP_001262249.1	C2A_Synaptotagmin-14_16	291..413	CDD:176035	27/134 (20%)
		C2B_Synaptotagmin-14_16	446..584	CDD:176053	33/139 (24%)
Tc2n	NP_083200.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	189..214		2/24 (8%)
		C2A_Tac2-N	239..341	CDD:176066	24/114 (21%)
		C2B_Tac2-N	352..486	CDD:176074	32/136 (24%)
		Nuclear localization signal	446..448		0/1 (0%)