Protein Alignment Syt14 and SYT1

DIOPT Version :10

• Sequence 1: NP_001262249.1
• Gene: Syt14 / 40544
• FlyBaseID: FBgn0261086
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: NP_005630.1
• Gene: SYT1 / 6857
• HGNCID: 11509
• Length: 422
• Species: Homo sapiens
• Alignment Length: 442
• Identity: 110/442 - (24%)
• Similarity: 198/442 - (44%)
• Gaps: 64/442 - (14%)

  Fly   169 DSHTGVLTG--LSKATTTVPHPATAFRNPCGE------HRAKTQALRYQHRVNVAAPPKLDKERD 225
            :||...|..  ::...|.:|..||...:| ||      .:.|.:.:...|::.:  ||..
Human     4 ESHHEALAAPPVTTVATVLPSNATEPASP-GEGKEDAFSKLKEKFMNELHKIPL--PPWA----- 60

  Fly   226 NVLVVPMVNAYSI--------------NNNNNSITTSNNHPSSNNNDDEPLFDTSDLRSIKSDD- 275
             ::.:.:|....:              ..|...........:.|..|.:.|..|...:::|.||
Human    61 -LIAIAIVAVLLVLTCCFCICKKCLFKKKNKKKGKEKGGKNAINMKDVKDLGKTMKDQALKDDDA 124

  Fly   276 ---LLVGVDQKEPAVQRGPIELELSLLYDAPMRKMTVHVMQAKNLPPLGSGQTTHTQVRMLMLPS 337
               |..|.:::||..:....:|:.||.||....::.|.::||..||.|..|.|:...|::.:||.
Human   125 ETGLTDGEEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPD 189

  Fly   338 KKQKLKTKI-RSGENPQYMESFLLHRVNPEDVNNMGLRVRLYGCERLRKERLIGEAYVSFATVDL 401
            ||:|.:||: |...||.:.|.|.. :|...::....|.:.:|..:|..|..:|||..|...|||.
Human   190 KKKKFETKVHRKTLNPVFNEQFTF-KVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDF 253

  Fly   402 ELETNLWLPLEPRNTSSGLGSTSDLLSLARSESAGSTSSMQHGGVSELLLGLSYNGVTGRLSVEI 466
            ...|..|               .||.|..:.|..         .:.::...|.|....|:|:|.|
Human   254 GHVTEEW---------------RDLQSAEKEEQE---------KLGDICFSLRYVPTAGKLTVVI 294

  Fly   467 IKGSQFRSLSLNKAPDTYVKMVMVSSIGQEISRAKTSIRRGQPNPLFKETFAFQVALFQLNDVTL 531
            ::....:.:.:....|.|||:.::.: |:.:.:.||:|::...||.:.|:|:|:|...|:..|.:
Human   295 LEAKNLKKMDVGGLSDPYVKIHLMQN-GKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQV 358

  Fly   532 MISVYAKRHMKKNEMVGWFSLGLNSSGSEEVAHWADVCEMPKGEMLARWHVL 583
            :::|.....:.||:.:|...:|.||:|: |:.||:|:...|: ..:|:||.|
Human   359 VVTVLDYDKIGKNDAIGKVFVGYNSTGA-ELRHWSDMLANPR-RPIAQWHTL 408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt14	NP_001262249.1	C2A_Synaptotagmin-14_16	291..413	CDD:176035	40/122 (33%)
		C2B_Synaptotagmin-14_16	446..584	CDD:176053	39/138 (28%)
SYT1	NP_005630.1	Syt1_N	6..113	CDD:409248	18/115 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	113..142		8/28 (29%)
		Phospholipid binding. /evidence=ECO:0000305	136..382		73/271 (27%)
		C2A_Synaptotagmin-1-5-6-9-10	143..265	CDD:176031	42/137 (31%)
		C2B_Synaptotagmin-1	274..409	CDD:176047	39/138 (28%)