Protein Alignment Syt14 and SYT13

DIOPT Version :10

• Sequence 1: NP_001262249.1
• Gene: Syt14 / 40544
• FlyBaseID: FBgn0261086
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: NP_065877.1
• Gene: SYT13 / 57586
• HGNCID: 14962
• Length: 426
• Species: Homo sapiens
• Alignment Length: 419
• Identity: 94/419 - (22%)
• Similarity: 165/419 - (39%)
• Gaps: 79/419 - (18%)

  Fly   200 RAKTQALRYQHRVNV------AAPPKLDKERDNVLVVPMVNAYSINNNNNSITTSNNHPSSNNND 258
            :||...|....:.||      ..|..|.|..|.....|.|.|..:.|..:....|...|::..:.
Human    50 KAKPSLLGSAQQFNVKKSTEPVQPRALLKFPDIYGPRPAVTAPEVINYADYSLRSTEEPTAPASP 114

  Fly   259 DEPLFDTSDLRSIKSDDLLV----GV-----------DQKEPAVQRGPIELELSLLYDAPMRKMT 308
            ..|  :.|.|:...:::|.:    ||           .:|..:..:.| :|...|.||....::.
Human   115 QPP--NDSRLKRQVTEELFILPQNGVVEDVCVMETWNPEKAASWNQAP-KLHYCLDYDCQKAELF 176

  Fly   309 VHVMQAKNLPPLG----------SGQTTHTQVRMLMLPSKKQKLKTKIRSGENPQYMESFLLHRV 363
            |..::|......|          :.:|...:.:..:   ||::|.|....|         |:..:
Human   177 VTRLEAVTSNHDGGCDCYVQGSVANRTGSVEAQTAL---KKRQLHTTWEEG---------LVLPL 229

  Fly   364 NPEDVNNMGLRVRLYGCERLRKERLIGEAYVSFATVDLELETNLWLPLEPRNTSSGLGSTSDLLS 428
            ..|::....|.:.|..|:|..:..:.||               |.|.|:..:...|.....:|.:
Human   230 AEEELPTATLTLTLRTCDRFSRHSVAGE---------------LRLGLDGTSVPLGAAQWGELKT 279

  Fly   429 LARSESAGSTSSMQHGGVSELLLGLSYNGVTGRLSVEIIKGSQFRSLSLNK--APDTYVKMVMVS 491
            .|:..|||:         .|:||.:||.....||.|.:||.....|....:  ..|..|| |.:.
Human   280 SAKEPSAGA---------GEVLLSISYLPAANRLLVVLIKAKNLHSNQSKELLGKDVSVK-VTLK 334

  Fly   492 SIGQEISRAKTSIRRGQPNPLFKETFAFQVA--LFQLNDVTLMISVYAKRHMKKNEMVGWFSLGL 554
            ...:::.:.:|...:.:.||::.|...|::.  |.|.:.|.|  .|..:....::..:|..||||
Human   335 HQARKLKKKQTKRAKHKINPVWNEMIMFELPDDLLQASSVEL--EVLGQDDSGQSCALGHCSLGL 397

  Fly   555 NSSGSEEVAHWADVCEMPKGEMLARWHVL 583
            ::||||. :||.::.:.|: ..:|.||.|
Human   398 HTSGSER-SHWEEMLKNPR-RQIAMWHQL 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt14	NP_001262249.1	C2A_Synaptotagmin-14_16	291..413	CDD:176035	25/131 (19%)
		C2B_Synaptotagmin-14_16	446..584	CDD:176053	41/142 (29%)
SYT13	NP_065877.1	C2A_Synaptotagmin-13	160..277	CDD:176059	26/144 (18%)
		C2B_Synaptotagmin-13	288..425	CDD:176052	41/151 (27%)