Protein Alignment Syt14 and Sytl3

DIOPT Version :10

• Sequence 1: NP_001262249.1
• Gene: Syt14 / 40544
• FlyBaseID: FBgn0261086
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: XP_006227950.1
• Gene: Sytl3 / 499017
• RGDID: 1561992
• Length: 609
• Species: Rattus norvegicus
• Alignment Length: 636
• Identity: 114/636 - (17%)
• Similarity: 216/636 - (33%)
• Gaps: 172/636 - (27%)

  Fly    58 ERHLAVKCVQKITRKRRYENTSSDSEEDILRRLRWHQQH--QLGEKPGGYGLGISQANPLTAQSF 120
            ||.:.::.:.:       :.|....||:.:|.|:.|.||  ..|.|               :.|.
  Rat    14 ERDIILRVLYR-------DQTVQSIEEERVRNLKTHLQHLRWKGAK---------------SSSQ 56

  Fly   121 NYHQAGASADLQRVTVSRDPLAIAERGKVGIPSSHSECS-------SNDSMEVSV---DSHTGVL 175
            .|.:...:...|.:.:      :..||.|....||..||       ...:.:.:|   |.:..:.
  Rat    57 EYKEKCCARCQQTLGL------LLNRGAVCQGCSHRVCSECRVFLRKTHAWKCTVCFEDRNVKIK 115

  Fly   176 TG-------------------------------LSKATTTVPHPATAFRNPCGEHRAKTQALRYQ 209
            ||                               .||.:...|.|.....:.||....:.|.|.:.
  Rat   116 TGEWFFEERARKFPTAGRRETAGARLLQSYQRQSSKISVVPPTPPPLSESQCGGSPNRLQELGHF 180

  Fly   210 HRVNVAAPPKLDKERDNVLVVPMVNAYSINNNNNSITTSNN-----------HPSSNNNDDEPLF 263
            ...|        |..:|:.:........::.:.|.:|:..:           |....:..|..:.
  Rat   181 RGFN--------KSVENLFLSVTTQMRKLSKSQNDMTSEKHLLAMDPRQCMGHTERRSQSDTAVN 237

  Fly   264 DTSDLRSIKSDDLLVGVDQKEPAVQRGPI------------------------------------ 292
            .||  |...:.|:|....|::|.....|:
  Rat   238 VTS--RKTSTPDILKAFHQEDPRHPPSPVLKQDTPPSSPTHSTVFSGGLRHGSLISVNSTCTEMG 300

  Fly   293 ---------ELELSLLYDAPMRKMTVHVMQAKNLPPLGSGQTTHTQ----VRMLMLPSKKQKLKT 344
                     |:|.::.|......:.:.:...||   |..|:....:    |:..:||.:..:.|.
  Rat   301 NFDNANVTGEIEFAIHYCVNSHSLEICIKTCKN---LAYGEDKRRKCNPYVKTYLLPDRSSQGKR 362

  Fly   345 KIRSGEN---PQYMESFLLHRVNPEDVNNMGLRVRLYGCERLRKERLIGEAYVSFATVDLE---L 403
            |.|..:|   |.:.|: |.::|:|..:....|:|.::....|.:...:||..:..||.|.|   .
  Rat   363 KTRVQKNTLDPTFEET-LKYQVDPAQLATRRLQVSVWHLGTLARRVFLGEVILPLATWDFEGSAA 426

  Fly   404 ETNLWLPLEPR--NTSSGLGSTSDLLSL-ARSESAGSTSSMQHGGVSELLLGLSYNGVTGRLSVE 465
            :...|.||..:  .....:..|:..|:: |:.........:|.....:|.|       .|:|.:
  Rat   427 QNARWYPLRAKAEKYEENIPQTNGELAVRAKLVLPVGPRMLQEAQEDQLAL-------NGQLCL- 483

  Fly   466 IIKGSQFRSLSLNKAPDTYVKMVMVSSIGQEISRAKTSIRRGQPNPLFKETFAFQ-VALFQLNDV 529
            ::.|::...:..:...:::||..:.....|:: |.|:.:.:.|..|.:|.:|.|. |:..||...
  Rat   484 VVLGAKNLPVRSDGTLNSFVKGCLTLPDQQKL-RVKSPVLKKQACPQWKHSFVFNGVSSSQLRQS 547

  Fly   530 TLMISVYAKRHMKKNE-MVGWFSL-------GLNSSGSEEVAHWADVCEMP 572
            ||.::|:.:.....|: ::|...|       |...|.|:....|..|...|
  Rat   548 TLELTVWDQAMFGMNDRLLGEAKLGSKGGAPGCTDSCSQSKLQWQKVLSSP 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt14	NP_001262249.1	C2A_Synaptotagmin-14_16	291..413	CDD:176035	32/176 (18%)
		C2B_Synaptotagmin-14_16	446..584	CDD:176053	30/136 (22%)
Sytl3	XP_006227950.1	PHD_SF	14..123	CDD:473978	26/136 (19%)
		FYVE_like_SF	60..108	CDD:333710	9/53 (17%)
		C2	308..435	CDD:472691	30/130 (23%)
		C2B_SLP_1-2-3-4	449..609	CDD:175987	33/159 (21%)