Protein Alignment Syt14 and Sytl2

DIOPT Version :10

• Sequence 1: NP_001262249.1
• Gene: Syt14 / 40544
• FlyBaseID: FBgn0261086
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: NP_001101962.2
• Gene: Sytl2 / 361604
• RGDID: 1307647
• Length: 2155
• Species: Rattus norvegicus
• Alignment Length: 550
• Identity: 112/550 - (20%)
• Similarity: 195/550 - (35%)
• Gaps: 130/550 - (23%)

  Fly    70 TRKRRYENTSSDSEE--DILRRLRWHQQHQLGEKPGGYGLGISQANPLTAQSFNYHQAGASADLQ 132
            :.:..:.||||..||  .:|:.|......::..|                            .|:
  Rat  1682 SNRESWRNTSSSEEEHSPVLKTLERRAARKIPSK----------------------------SLE 1718

  Fly   133 RVTVSRDPLAIAERGKVGIPSSHSECSSNDSMEVSVDSHTG-VLTGLSKATTTVPH-PATAFRNP 195
            .:     |...:.:.||.........|:.|..:...|..|. .:.|:|    |||. |...|.:|
  Rat  1719 DI-----PSDSSNQAKVDNLPEELVRSAEDDQKADQDPDTNECIPGIS----TVPSLPDNPFSHP 1774

  Fly   196 CGEHRAKTQALRYQHRVNVAAPPKL-----DKERDNVLVVPMVNAYSINNNNNSITTSNNHPSSN 255
                    ..|:   |::.:.|..|     |:|.|..    ..::|.:.....|       |||.
  Rat  1775 --------DKLK---RMSKSVPAFLQDESDDRETDTA----SESSYQLRRYKKS-------PSSL 1817

  Fly   256 NNDDEPLFDTSDLRSIKSDDLLVGVDQKEPAVQRGPIE----LELSLLYDAPMRKMTVHVMQAKN 316
            .|    |..:|.:.|:.|..   |......:...|.:|    ::.::.|...::::.|.|.|.|:
  Rat  1818 TN----LSSSSGMTSLSSAS---GSVMSVYSGDFGNLEVKGSVQFAIDYVESLKELHVFVAQCKD 1875

  Fly   317 LPPL-GSGQTTHTQVRMLMLPSKKQKLKTK---IRSGENPQYMESFLLHRVNPEDVNNMGLRVRL 377
            |... ...|.:...|:..:||.|.:..|.|   ::...||.|.| .|.:::..:.:....|.:.:
  Rat  1876 LAAADAKKQRSDPYVKTYLLPDKGKMGKKKTLVVKKTLNPVYNE-ILRYKIERQVLKTQKLNLSV 1939

  Fly   378 YGCERLRKERLIGEAYVSFATVDLELETN---LWLPLEPRNTSSGL-----GSTSDLLSLARSES 434
            :..:..::...:||..:...|.|.:.:.|   .|.||:.:.....|     |.....|......|
  Rat  1940 WHRDTFKRNSFLGEVELDLETWDWDSKQNKQLKWYPLKRKTAPVALETENRGEMKLALQYVPEPS 2004

  Fly   435 AGS---TSSMQHGGVSELLLGLSYNGVTGRLSVEIIKGSQFRSLSLNKAPDTYVKMVMVSSIGQE 496
            .|.   |:...|..|.|.            |.:.:::||...|         :||..::....::
  Rat  2005 PGKKLPTTGEVHIWVKEC------------LDLPLLRGSHLNS---------FVKCTILPDTSRK 2048

  Fly   497 ISRAKTSIRRGQPNPLFKETFAFQVALFQLND-VTLMISVYAKRHMK-KNEMVGWFSLGL---NS 556
             ||.||.......||:|..|..:..  |:..| :...:.:....|.| .|:.:|...:|.   .|
  Rat  2049 -SRQKTRAVGKTSNPVFNHTMVYDG--FRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKS 2110

  Fly   557 SGSEEVAHWADVCEMPKGEMLARWHVLVDS 586
            .|:|  ..|.|    ...|..|.|..:|:|
  Rat  2111 YGTE--VDWMD----STSEEAALWEKMVNS 2134

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt14	NP_001262249.1	C2A_Synaptotagmin-14_16	291..413	CDD:176035	28/132 (21%)
		C2B_Synaptotagmin-14_16	446..584	CDD:176053	31/142 (22%)
Sytl2	NP_001101962.2	PHD_SF	5..>51	CDD:473978
		rad2	<197..>425	CDD:273166
		PTZ00108	<1592..1812	CDD:240271	33/181 (18%)
		C2A_SLP-1_2	1850..1977	CDD:176039	26/127 (20%)
		C2B_SLP_1-2-3-4	1990..2146	CDD:175987	38/174 (22%)