Protein Alignment Syt14 and Rph

DIOPT Version :10

• Sequence 1: NP_001262249.1
• Gene: Syt14 / 40544
• FlyBaseID: FBgn0261086
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Alignment Length: 602
• Identity: 124/602 - (20%)
• Similarity: 238/602 - (39%)
• Gaps: 116/602 - (19%)

  Fly    50 RHAI----NCC-----------DERHLAVKCVQKITRK------RRYENTSSDSEEDILRRLRWH 93
            :||:    |||           .:|.|...|.|.:..|      .|| :||..|.|..|.|: ..
  Fly    78 QHAVERGPNCCRLCGDTFGILRPQRILCEDCRQSVCTKCSVDINIRY-HTSERSREIWLCRI-CS 140

  Fly    94 QQHQLGEKPGGY---GL------GISQANPLTAQSFNYHQAGASADLQRVTVSRDPLAIAERGKV 149
            :..::.:|.|.:   ||      ..:.|.|:...... ..||.:..:|....:....|..::..:
  Fly   141 ETREMWKKSGAWFFKGLPKYDMPRSASATPIPNPGPG-SMAGDTRAVQSCHATPTRPARVKKLTI 204

  Fly   150 GIPSSHSECSSNDSMEVSVDSHTGVLT-----GLSK--ATTTVPHPATAFR-------------- 193
            .:..|.|..|.:...|..||:..|:..     |::|  |:|.:.. ..:||
  Fly   205 RVNDSSSSSSGHSEPEDEVDTGVGIGVGVVGGGMAKGIASTRLQR-EDSFRLRAYGSIRSFIDGG 268

  Fly   194 -----NPCGEHRAKTQALRYQHRVNVAAPPKLDKERDNVLVVPMVNAYSINNNNNSITTSNNHPS 253
                 |....:|.::|........:..:..||.:|...:....:.:::||::::.|  .|||
  Fly   269 ERKLSNSFFFNRQQSQRPSECPEYDSVSMSKLRRESSFLRRGSVSSSWSISDSSGS--GSNN--- 328

  Fly   254 SNNNDDEPLFDTSDLRSIKSDDLLVGVDQKEPAVQ---RGPI--ELELSLLYDAPMRKMTVHVMQ 313
            |.|:..:..:                 .|.:..:|   |.|:  .||:::.|......:...:::
  Fly   329 SGNSQTQSQY-----------------QQHQQQLQQHCRDPLLGWLEIAISYREAFHSLDCTMVR 376

  Fly   314 AKNLPPLGSGQTTHTQVRM-LMLP------SKKQKLKTKIRSGENPQYMESFLLHRVNPEDVNNM 371
            |::||.:.:........:: ::.|      ::.|:.|| :....||::.|:.....|.||::.|.
  Fly   377 ARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQRTKT-VHKTRNPEFNETLQFVGVEPEELGNS 440

  Fly   372 GLRVRLYGCERLRKERLIGEAYVSFATVDLELETNLWLPLEPRNTSSGLGSTSDLLSLARSESAG 436
            .:.|.|:..::...: .:|.|.|..:||....:..:.:||.                 ...:.:.
  Fly   441 LIYVALFDDDKYGHD-FLGAAKVCLSTVHSTSQYRISVPLG-----------------VEDQYSN 487

  Fly   437 STSSMQHGGVSELLLGLSYNGVTGRLSVEIIKGSQFRSLSLNKAPDTYVKMVMVSSIGQEISRAK 501
            :....|:....::||.|.||.....|.|.:.:.....::..|.:.|.:|| :.:.....:..:.|
  Fly   488 AAEMAQNWPNGKMLLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVK-IQLKPDAHKNKKHK 551

  Fly   502 TSIRRGQPNPLFKETFAFQVALFQLNDVTLMISVYAKRHMKKNEMVGWFSLGLNSSGSEEVAHWA 566
            ||::....||::.|.|.|:.:...||...|:::|:.|...|.|:.:|...||..|.| |.:..|.
  Fly   552 TSVKWRTLNPIYNEEFYFEASPHDLNKEMLILTVWDKDLGKSNDFLGSLQLGAQSKG-ERLQQWL 615

  Fly   567 DVCEMPKGEMLARWHVL 583
            |...:| .....:||.|
  Fly   616 DCIRLP-DHFHEKWHCL 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt14	NP_001262249.1	C2A_Synaptotagmin-14_16	291..413	CDD:176035	27/130 (21%)
		C2B_Synaptotagmin-14_16	446..584	CDD:176053	38/138 (28%)
Rph	NP_572651.1	FYVE_like_SF	84..172	CDD:333710	22/89 (25%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	24/124 (19%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	37/134 (28%)