Protein Alignment Syt14 and Sytl1

DIOPT Version :10

• Sequence 1: NP_001262249.1
• Gene: Syt14 / 40544
• FlyBaseID: FBgn0261086
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: NP_113570.2
• Gene: Sytl1 / 269589
• MGIID: 1933365
• Length: 568
• Species: Mus musculus
• Alignment Length: 552
• Identity: 128/552 - (23%)
• Similarity: 211/552 - (38%)
• Gaps: 85/552 - (15%)

  Fly    78 TSSDSE--EDILRR---LRWHQQHQLGEKPGGYGLGISQANP-----LT------AQSFNYHQAG 126
            |..:.|  .|:|:|   ||..::.::.:      |..|..:|     ||      |:|..:|.|.
Mouse    38 TEEEQEAISDVLKRDAHLRQLEEGRVSK------LRASLEDPWQLKILTGDWFQEARSQRHHHAH 96

  Fly   127 ASADLQRVTVSR-----DPLAIAERGK---VGIPSSHSECSSNDSMEVSVDSHTGVLTGLSKATT 183
            ..:||.|.::.|     ...|:...|:   .|..:...|..|..|:||:.........|....:.
Mouse    97 FGSDLVRASIRRKKSPKGDQALGSDGEAEAAGENTIEGEPESRVSIEVAAPERNTETQGPDLFSP 161

  Fly   184 TVPHPATAFRNPCGEHRAKTQALRY----QHRVNVA-APPKLDKERDNVLVVPMVNAYSINNNNN 243
            .||..|:..:    |...:.|....    :..|.|| |.|:||.|:..........|.| ...:.
Mouse   162 YVPSKASEGQ----EEEPQDQECELEAPGEGGVQVAEADPELDPEQKAEQESQPTPAQS-KATSK 221

  Fly   244 SITTSNNHPSSNNNDDEPLFDTSDLRSIKSDDLLVGVDQKEPAVQRGPIELE----LSLLYDAPM 304
            .:......|....:.|..|..:|.:.|:.|..|...:.......:.|.:::.    .||.|:...
Mouse   222 ILENGEEAPGLGPSLDRMLSSSSSVSSLNSSTLSGSLMSLSGEAEAGTVQVRGSVLFSLRYEPGT 286

  Fly   305 RKMTVHVMQAKNLPPLGSGQTTHTQVRMLMLPSKKQKLKTKIRSGE-NPQYMESFLLHRVNPEDV 368
            .::.|.|:|.:.| .....:.:...|:..:||.|:.|.||.::... ||.:.|: |.|.|...|:
Mouse   287 SELRVQVIQCQGL-AAARRRRSDPYVKSYLLPDKQSKRKTSVKKRNLNPIFNET-LRHSVQQADL 349

  Fly   369 NNMGLRVRLYGCERLRKERLIGEAYVSFATVDLELETNLWLPLEPR-------NTSSGLGSTSDL 426
            ....|.:.::..|.|.:...:||..|...|.:.:.|.. ||||:||       ..|.||.|.|..
Mouse   350 PGRVLSLSVWHRESLGRNIFLGEVEVPLDTWNWDSEAT-WLPLQPRVPPSPDELPSRGLLSLSLK 413

  Fly   427 LSLARSESAGSTSSMQ-HGGVSELLLGLSYNGVTGRLSVEIIKGSQFRSLSLNKAPDTYVKMVMV 490
            ...|.||..|...|.: |..|.|           .:..|.:..||.          |||::..::
Mouse   414 YVPAGSEGGGQPQSGELHFWVKE-----------AQSLVPLRPGSL----------DTYIQCSVL 457

  Fly   491 SSIGQEISRAKTSIRRGQPNPLFKETFAFQ-VALFQLNDVTLMISVYAKRHMKKNEMVGW-FSLG 553
            .. ....||.:|.:.|...:|:|..|..:. .....|......:|::....:...::.|. .|||
Mouse   458 PD-DSRASRQRTRVVRRSLSPVFNHTMVYDGFGPADLRQACAELSLWDHGALASRQLGGTRLSLG 521

  Fly   554 LNSSGSEEVAHWADVCEMPKGEMLARWHVLVD 585
            ..||...:|. |.|  ..|:.:.|  |..|::
Mouse   522 TGSSYGLQVP-WMD--STPEEKQL--WQTLLE 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt14	NP_001262249.1	C2A_Synaptotagmin-14_16	291..413	CDD:176035	33/126 (26%)
		C2B_Synaptotagmin-14_16	446..584	CDD:176053	29/139 (21%)
Sytl1	NP_113570.2	PHD_SF	35..>90	CDD:473978	13/57 (23%)
		NESP55	<92..230	CDD:115071	30/142 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	103..255		32/156 (21%)
		C2	273..392	CDD:472691	32/121 (26%)
		C2B_SLP_1-2-3-4	405..561	CDD:175987	40/171 (23%)