Protein Alignment Syt14 and Syt4

DIOPT Version :10

• Sequence 1: NP_001262249.1
• Gene: Syt14 / 40544
• FlyBaseID: FBgn0261086
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: NP_033334.2
• Gene: Syt4 / 20983
• MGIID: 101759
• Length: 425
• Species: Mus musculus
• Alignment Length: 606
• Identity: 121/606 - (19%)
• Similarity: 218/606 - (35%)
• Gaps: 207/606 - (34%)

  Fly     2 IVTSASGLDSTPTLGTIEVTTLLGAF--FGVLVLLLLLFLFISRKCC------------FHYRHA 52
            |.||....|        |:.|::|.|  || ||..:.||.:|   ||            :.:.|.
Mouse     4 ITTSRVEFD--------EIPTVVGIFSAFG-LVFTVSLFAWI---CCQRRSAKSNKTPPYKFVHV 56

  Fly    53 INCCDERHLAVKCVQKITRKRRYENTSSDSEEDI-----LRRLRWHQQHQLGEKPGGYGLGISQA 112
            :...|      ...:.::.|:::   ..|.:.::     |..|..|...:..:..|.:    .:|
Mouse    57 LKGVD------IYPENLSSKKKF---GGDDKSEVKGKAALPNLSLHLDLEKRDLNGNF----PKA 108

  Fly   113 NPLTAQSFNYHQAGASADLQRVTVSRDPLAIAERGKVGIPSSHSECSSNDSMEVSVDSHTGVLTG 177
            ||         :||:|:||:.||
Mouse   109 NP---------KAGSSSDLENVT------------------------------------------ 122

  Fly   178 LSKATTTVPHPATAFRNPCGEHRAKTQALRYQHRVNVAAPPKLDKERDNVLVVPMVNAYSINNNN 242
                                                    |||..|.:.
Mouse   123 ----------------------------------------PKLFTETEK---------------- 131

  Fly   243 NSITTSNNHPSSNNNDDEPLFDTSDLRSIKSDDLLVGVDQKEPAVQRGPIELELSLLYDAPMRKM 307
                 ..|.|                .|:||...|...:::|   :.|  .|.|||.|:...:..
Mouse   132 -----EANSP----------------ESLKSSTSLTSEEKQE---KLG--TLFLSLEYNFEKKAF 170

  Fly   308 TVHVMQAKNLPPLG-SGQTTHTQVRMLMLPSKKQKLKTKI-RSGENPQYMESFLLHRVNPEDVNN 370
            .|::.:|:.||.:. ...|:...::|.:||.||.::||:: |...:|.:.|:|..:.:....:..
Mouse   171 VVNIKEAQGLPAMDEQSMTSDPYIKMTILPEKKHRVKTRVLRKTLDPVFDETFTFYGIPYPHIQE 235

  Fly   371 MGLRVRLYGCERLRKERLIGEAYVSFATVDLELETNLWLPLEPRNTSSG-LGSTSDLLSLARSES 434
            :.|...:...:|..::.:|||..:..:.::|               |.| :..|.:::.....:|
Mouse   236 LSLHFTVLSFDRFSRDDVIGEVLIPLSGIEL---------------SDGKMLMTREIIKRNAKKS 285

  Fly   435 AGSTSSMQHGGVSELLLGLSYNGVTGRLSVEIIKGSQFRSLSLNKAPDTYVKMVMVSSIGQEISR 499
            :|.         .|||:.|.|...|..|:|.::|........::...|.||| |.:....:.||:
Mouse   286 SGR---------GELLVSLCYQSTTNTLTVVVLKARHLPKSDVSGLSDPYVK-VNLYHAKKRISK 340

  Fly   500 AKTSIRRGQPNPLFKETFAFQVALFQLNDVTLMISVYAKRHMKKNEMVGWFSLGLNSSGSEEVAH 564
            .||.:::..||.:|.|.|.|.:....|.::::...|.......:||::|...||..:.||.. .|
Mouse   341 KKTHVKKCTPNAVFNELFVFDIPCESLEEISVEFLVLDSERGSRNEVIGRLVLGATAEGSGG-GH 404

  Fly   565 WADVCEMPKGEMLARWHVLVD 585
            |.::|:.|: ..:|:||:|.|
Mouse   405 WKEICDFPR-RQIAKWHMLCD 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt14	NP_001262249.1	C2A_Synaptotagmin-14_16	291..413	CDD:176035	27/123 (22%)
		C2B_Synaptotagmin-14_16	446..584	CDD:176053	40/137 (29%)
Syt4	NP_033334.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	127..147		7/56 (13%)
		C2A_Synaptotagmin-4-11	153..279	CDD:176034	31/142 (22%)
		C2B_Synaptotagmin-4	288..423	CDD:176049	40/146 (27%)