Protein Alignment Syt14 and SYT2

DIOPT Version :10

• Sequence 1: NP_001262249.1
• Gene: Syt14 / 40544
• FlyBaseID: FBgn0261086
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: XP_016855798.1
• Gene: SYT2 / 127833
• HGNCID: 11510
• Length: 479
• Species: Homo sapiens
• Alignment Length: 306
• Identity: 89/306 - (29%)
• Similarity: 156/306 - (50%)
• Gaps: 32/306 - (10%)

  Fly   279 GVDQKEPAVQRGPIELELSLLYDAPMRKMTVHVMQAKNLPPLGSGQTTHTQVRMLMLPSKKQKLK 343
            |.::|||. ..|  :|:.||.||....::||.|:||..||.|..|.|:...|::.:||.||:|.:
Human   191 GEEEKEPE-NLG--KLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYE 252

  Fly   344 TKI-RSGENPQYMESFLLHRVNPEDVNNMGLRVRLYGCERLRKERLIGEAYVSFATVDLELETNL 407
            ||: |...||.:.|:|.. :|..:::....|.:.:|..:|..|..:|||..|...||||......
Human   253 TKVHRKTLNPAFNETFTF-KVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEE 316

  Fly   408 WLPLEPRNTSSGLGSTSDLLSLARSESAGSTSSMQHGGVSELLLGLSYNGVTGRLSVEIIKGSQF 472
            |..|:        |...:     ..|..|           ::...|.|....|:|:|.|::....
Human   317 WRDLQ--------GGEKE-----EPEKLG-----------DICTSLRYVPTAGKLTVCILEAKNL 357

  Fly   473 RSLSLNKAPDTYVKMVMVSSIGQEISRAKTSIRRGQPNPLFKETFAFQVALFQLNDVTLMISVYA 537
            :.:.:....|.|||:.::.: |:.:.:.||::::...||.|.|:|:|::...|:..|.::::|..
Human   358 KKMDVGGLSDPYVKIHLMQN-GKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVVTVLD 421

  Fly   538 KRHMKKNEMVGWFSLGLNSSGSEEVAHWADVCEMPKGEMLARWHVL 583
            ...:.|||.:|...:|.|::|: |:.||:|:...|: ..:|:||.|
Human   422 YDKLGKNEAIGKIFVGSNATGT-ELRHWSDMLANPR-RPIAQWHSL 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt14	NP_001262249.1	C2A_Synaptotagmin-14_16	291..413	CDD:176035	43/122 (35%)
		C2B_Synaptotagmin-14_16	446..584	CDD:176053	38/138 (28%)
SYT2	XP_016855798.1	Syt2_N	61..170	CDD:409249
		C2A_Synaptotagmin-1-5-6-9-10	199..321	CDD:176031	43/124 (35%)
		C2B_Synaptotagmin-1	331..466	CDD:176047	39/149 (26%)