Protein Alignment Syt14 and TC2N

DIOPT Version :10

• Sequence 1: NP_001262249.1
• Gene: Syt14 / 40544
• FlyBaseID: FBgn0261086
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: NP_689545.2
• Gene: TC2N / 123036
• HGNCID: 19859
• Length: 490
• Species: Homo sapiens
• Alignment Length: 514
• Identity: 100/514 - (19%)
• Similarity: 202/514 - (39%)
• Gaps: 125/514 - (24%)

  Fly   132 QRVTVSRDPL-AIAERGKVGIPSSH--SECSSNDSMEV-----------------SVDSHTGVLT 176
            |..|:|..|| :::.:.::|....:  |:..| |..||                 ...||...|.
Human    37 QNATISVPPLTSVSVKPQLGCTEDYLLSKLPS-DGKEVPFVVPKFKLSYIQPRTQETPSHLEELE 100

  Fly   177 GLSKA---------TTTVPH-PATAFRNPCGEHRAKTQALRYQH---RVNVAAPPKLDKER---- 224
            |.::|         :::..| |:....||         ...|||   .::...||:.:.:|
Human   101 GSARASFGDRKVELSSSSQHGPSYDVYNP---------FYMYQHISPDLSRRFPPRSEVKRLYGS 156

  Fly   225 ------DNVLVVPMVNAYSINNNNNSITTSNNH------PSSNNNDDEPLFDTSDLRSIKSDDLL 277
                  :.:...|.::....:..|:|......|      |||:::...   .....||:  |.:.
Human   157 VCDLRTNKLPGSPGLSKSMFDLTNSSQRFIQRHDSLSSVPSSSSSRKN---SQGSNRSL--DTIT 216

  Fly   278 VGVDQKEPAVQRGPIELELSLLYDAPMRKMTVHVMQAKNLP-PLGSGQTTHTQVRMLMLPSKKQK 341
            :..|:::..      .|.:.|.|::.:.::.:.|:|.::|. |...|.|....::.::...|...
Human   217 LSGDERDFG------RLNVKLFYNSSVEQIWITVLQCRDLSWPSSYGDTPTVSIKGILTLPKPVH 275

  Fly   342 LKTKIRSGENP-QYMESFLLHRVNPEDVNNMGLRVRLYGCERLR----------KERLIGEAYVS 395
            .|:..:.|.|. ::||:|:             ..::|...:.:|          :::.|||..:|
Human   276 FKSSAKEGSNAIEFMETFV-------------FAIKLQNLQTVRLVFKIQTQTPRKKTIGECSMS 327

  Fly   396 FATVDLELETNLWLPLEPRNTSSGLGSTSDLLSLARSESAGSTSSMQHGGVSELLLGLSYNGVTG 460
            ..|:..: |.:..|.:.|                      .|..|:.|   :||.||..:..|..
Human   328 LRTLSTQ-EMDYSLDITP----------------------PSKISVCH---AELELGTCFQAVNS 366

  Fly   461 RLSVEIIKGSQFRSLSLNKAPDTYVKMVMVSSIGQEISRAKTSIRRGQPNPL-FKETFAFQVALF 524
            |:.::|::.....|.|.......:||:.|.|| |:.|.:.||.:.:.....: :.||..|.:...
Human   367 RIQLQILEARYLPSSSTPLTLSFFVKVGMFSS-GELIYKKKTRLLKASNGRVKWGETMIFPLIQS 430

  Fly   525 QLNDVTLMISVYAKRHMKKNEMVGWFSLGLNSSGSEEVAHWADVCEMPKGEMLARWHVL 583
            : .::..:|.:|::..:::...||...:..:|:..|.|..|.:....|: :::.|||.|
Human   431 E-KEIVFLIKLYSRSSVRRKHFVGQIWISEDSNNIEAVNQWKETVINPE-KVVIRWHKL 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt14	NP_001262249.1	C2A_Synaptotagmin-14_16	291..413	CDD:176035	25/133 (19%)
		C2B_Synaptotagmin-14_16	446..584	CDD:176053	34/139 (24%)
TC2N	NP_689545.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	189..215		7/30 (23%)
		C2A_Tac2-N	240..342	CDD:176066	22/115 (19%)
		C2B_Tac2-N	353..487	CDD:176074	33/136 (24%)
		Nuclear localization signal. /evidence=ECO:0000255	447..449		0/1 (0%)