Protein Alignment CG14450 and TEFM

DIOPT Version :10

• Sequence 1: NP_649411.1
• Gene: CG14450 / 40490
• FlyBaseID: FBgn0037184
• Length: 372
• Species: Drosophila melanogaster
• Sequence 2: NP_078959.3
• Gene: TEFM / 79736
• HGNCID: 26223
• Length: 360
• Species: Homo sapiens
• Alignment Length: 357
• Identity: 72/357 - (20%)
• Similarity: 143/357 - (40%)
• Gaps: 54/357 - (15%)

  Fly    14 CLRLSSTQQHR---------SGQPECDQAIGLLPAYSDADRLKILKTINESSMNQIANYDITKA- 68
            |.|..||...:         ....|.:.|:..|  :|...:..||..:|.:|..::..:.:.:.
Human    32 CCRKKSTTPKKITPNVTFCDENAKEPENALDKL--FSSEQQASILHVLNTASTKELEAFRLLRGR 94

  Fly    69 RATKLQNWKNRHGPLQELSDILYVEGFGLKVTTKFFKSLLAPPSSGSAQVGENRPKTARVAPFIT 133
            |:..:...:...||.|.|..::.|..|..|.|.:...|:|.|.:....:   ..|:...:...:.
Human    95 RSINIVEHRENFGPFQNLESLMNVPLFKYKSTVQVCNSILCPKTGREKR---KSPENRFLRKLLK 156

  Fly   134 PAMDEGQRSRIVSAVGVRIGVTSVSWARLKIGSNEAPCLLTHWQHHE-------LNDKKLHLSEL 191
            |.::..:...:.|.:.:..|...::||.|     :....:..||..:       :....::|.|:
Human   157 PDIERERLKAVNSIISIVFGTRRIAWAHL-----DRKLTVLDWQQSDRWSLMRGIYSSSVYLEEI 216

  Fly   192 SRRCLYVSHQIPVADCYVMESPQMAQASSNPGSIDQQNVNIQKAQVSAIMSFSLMARSDGDENKT 256
            |.    :..::|.||.||:|...::..:|:...| ..:.:|.:|.:.|:::.:.  ..||.
Human   217 SS----IISKMPKADFYVLEKTGLSIQNSSLFPI-LLHFHIMEAMLYALLNKTF--AQDGQ---- 270

  Fly   257 NNVYYMRRFLSARLFNHMVGTERVSSEDTILAMMRTHYNVEHQIPETEPPLKLHKQIDFPAD--- 318
            :.|..|.|....:.|..|:|..|.|.::.:...:            .:..||...::.||:|
Human   271 HQVLSMNRNAVGKHFELMIGDSRTSGKELVKQFL------------FDSILKADPRVFFPSDKIV 323

  Fly   319 -LRLEFSQQERYQRELLGQALLLSLAFTRLVL 349
             .|..|...|..:.|.|..:||.::||..|.:
Human   324 HYRQMFLSTELQRVEELYDSLLQAIAFYELAV 355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14450	NP_649411.1	None
TEFM	NP_078959.3	ComEA	77..>119	CDD:441164	7/41 (17%)
		RuvC-like	156..352	CDD:473878	46/223 (21%)