DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mael and Mael

DIOPT Version :9

Sequence 1:	NP_788566.1	Gene:	mael / 40489	FlyBaseID:	FBgn0016034	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_001102327.1	Gene:	Mael / 364039	RGDID:	1309333	Length:	434	Species:	Rattus norvegicus

Alignment Length:	468	Identity:	92/468 - (19%)
Similarity:	172/468 - (36%)	Gaps:	116/468 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SGFMMFVNEWRNRNAEGRRMTL-----AQAVSHCGTIW--------EPFQKMNTQQRGPYNSGGK 58
            :.:..||.|   :..|.||..|     |.|:.:|...|        |.:.:|..:.|.   :.||
  Rat     9 NAYYFFVQE---KIPELRRRGLPVARVADAIPYCSADWALLREDEKEKYSEMAREWRA---AQGK 67

  Fly    59 DANVAQRAKRESSNGHGQVDKAQR------EATESLMDMKRTIERLVLNAKMSHDLENAKFVFVA 117
            |:..:::.|..|:       ..:|      :.:.|..||..      |:.|....|....|.|:
  Rat    68 DSGPSEKQKLVST-------PLRRPGMLVPKPSVSPPDMSN------LSIKSDQALLGGVFYFL- 118

  Fly   118 FNYFTKA----LTTDVYVPAEFAACEYSLKEGIRSIYSTMIDPGQIIFGQGSDALLHSSTTHDLP 178
             |.|:..    .....::|.|....:|||:|||.:.:.:.|:||:|..|........|.::|.:|
  Rat   119 -NIFSHGELPPHCEQRFLPCEIGCVKYSLQEGIMADFHSFINPGEIPRGFRFHCQAASDSSHKIP 182

  Fly   179 LPPNALGEKNMTKLYRNIVDYLSKCQGKGKTLVVFTPAENITMVKSCFRYLECDDDFRDGGEKIQ 243
            :.....|....|.| :|:..::.  ...|....::..:::...|..|.:.:|...:.|...|.:.
  Rat   183 ISNFEFGHDQATVL-QNLYKFIH--PNPGNWPPIYCKSDDRARVNWCLKRMERASEIRQDLELLT 244

  Fly   244 VFDIQYLLFILKKEVMNVADLNDEKINKFATDAFFKK----DFFEFTAGIACQYHEDNDRTKYCT 304
            |.|:             |..:..:|..|..:..:.:.    ..:::::...|::||:|| ..:|.
  Rat   245 VEDL-------------VVGIYQQKFLKEPSKTWVRSLLDVAMWDYSSNTRCKWHEEND-ILFCA 295

  Fly   305 QSMVTRWAYTFTDFMCGDLAITVQPGKHIPAQ-------------------------TKPNYLII 344
            .::..:.||..::.:.....|.: .|.|:|.|                         ..|.:...
  Rat   296 LAVCKKIAYCISNSLATLFGIQL-TGAHVPLQDYEASNSVTPKMVVLDAGRYQKLRVESPGFCHF 359

  Fly   345 SSYASSLDHESSFDSFY-----------SLPGSGVKK--ESQPEA---------CSLSSSRLSVA 387
            :|| :.....:|...:|           |:.|.|:.:  ||...:         |..|.|.....
  Rat   360 NSY-NQEQRSNSSTGYYPSGVKISGSNSSVRGRGITRLLESISNSSNNIHRFSNCEASLSPYMPQ 423

  Fly   388 SSSYKPIDHTSFA 400
            ...|||.  :||:
  Rat   424 KDGYKPF--SSFS 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mael	NP_788566.1	Maelstrom	126..339	CDD:289764	44/241 (18%)
Mael	NP_001102327.1	HMG_box_2	2..72	CDD:401091	17/68 (25%)
Mael	NP_001102327.1	Maelstrom	130..324	CDD:404040	42/211 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341732
Domainoid	1	1.000	56	1.000	Domainoid score	I10764
eggNOG	1	0.900	-	-		E1_28M7A
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13143
Inparanoid	1	1.050	59	1.000	Inparanoid score	I5316
OMA	1	1.010	-	-		QHG47416
OrthoDB	1	1.010	-	-		D369131at33208
OrthoFinder	1	1.000	-	-		FOG0009912
OrthoInspector	1	1.000	-	-		oto97662
orthoMCL	1	0.900	-	-		OOG6_109678
Panther	1	1.100	-	-	LDO	PTHR21358
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770