DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trxr-2 and txnrd2.2

DIOPT Version :9

Sequence 1:	NP_524216.1	Gene:	Trxr-2 / 40475	FlyBaseID:	FBgn0037170	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001340325.1	Gene:	txnrd2.2 / 798259	ZFINID:	ZDB-GENE-040914-66	Length:	517	Species:	Danio rerio

Alignment Length:	488	Identity:	270/488 - (55%)
Similarity:	343/488 - (70%)	Gaps:	5/488 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 RYDYDLVVLGGGSAGLACAKEAAGCGARVLCFDYVKPTPVGTKWGIGGTCVNVGCIPKKLMHQAS 94
            ::||||||:||||.||||:||||..|.:|...|||:|:..|||||:||||||||||||||||||:
Zfish    30 KFDYDLVVIGGGSGGLACSKEAAQLGQKVAVLDYVEPSLKGTKWGLGGTCVNVGCIPKKLMHQAA 94

  Fly    95 LLGEAVHEAVAYGWNVDDTNIRPDWRKLVRSVQNHIKSVNWVTRVDLRDKKVEYVNSMATFRDSH 159
            |||.||.:|..|||.:.:| :..||..:..:||||::|:||..||.|:||||:|:|...|..|.|
Zfish    95 LLGTAVKDARKYGWQIPET-LSHDWPTMAEAVQNHVRSLNWGHRVQLQDKKVKYLNMKGTLLDKH 158

  Fly   160 TIEYVAMPGAEHRQVTSEYVVVAVGGRPRYP-DIPGAVELGITSDDIFSYEREPGRTLVVGAGYV 223
            |:..|...|.| ..||:..:::|.||||:|| .:|||:|.||||||||..:..|.:||::||.||
Zfish   159 TVRAVNAQGKE-MTVTARNILLATGGRPKYPTHVPGAMEFGITSDDIFWLKESPKKTLIIGASYV 222

  Fly   224 GLECACFLKGLGYEPTVMVRSIVLRGFDRQMSELLAAMMTERGIPFLGTTIPKAVERQADGRLLV 288
            .||||.||.|:|.:.:||||||.|||||:|||.|:...|...|..|.....||:||:...|.|.|
Zfish   223 SLECAGFLTGIGLDTSVMVRSIALRGFDQQMSGLVTDYMETYGTKFHWKCTPKSVEKLPSGHLQV 287

  Fly   289 RYRNTTTQMDGSDVFDTVLWAIGRKGLIEDLNLDAAGVKTHDD--KIVVDAAEATSVPHIFAVGD 351
            .:.:..|:.:..|.|::||||:||....:.|||:..|||.:.:  ||:|.|.||||||:|||:||
Zfish   288 TWMDLNTKEEHQDTFNSVLWAVGRAPETKTLNLEKVGVKINKETGKIIVAADEATSVPNIFAIGD 352

  Fly   352 IIYGRPELTPVAILSGRLLARRLFAGSTQLMDYADVATTVFTPLEYSCVGMSEETAIELRGADNI 416
            |..|||||||.||.:|:|||.||...||:||:|.:|||||||||||.|||:|||.|....|.|.|
Zfish   353 IGEGRPELTPTAIKAGKLLAHRLAGRSTELMNYENVATTVFTPLEYGCVGLSEEEAERRHGKDQI 417

  Fly   417 EVFHGYYKPTEFFIPQKSVRHCYLKAVAEVSGDQKILGLHYIGPVAGEVIQGFAAALKTGLTVKT 481
            ||:|.:|||.||.:.::....||:|.|....|||::||||:.||.||||.||||...:.|||.:.
Zfish   418 EVYHAFYKPLEFTVAERDATQCYIKVVCLREGDQRVLGLHFTGPNAGEVTQGFALGFQCGLTYEH 482

  Fly   482 LLNTVGIHPTTAEEFTRLSITKRSGRDPTPASC 514
            |.||||||||.|||.|:|:||||||.|.|...|
Zfish   483 LRNTVGIHPTCAEELTKLNITKRSGLDATVTGC 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-2	NP_524216.1	NADB_Rossmann	29..>68	CDD:304358	24/37 (65%)
		TGR	31..515	CDD:273624	270/487 (55%)
		NADB_Rossmann	<144..239	CDD:304358	48/95 (51%)
		Pyr_redox	214..288	CDD:278498	38/73 (52%)
		Pyr_redox_dim	388..497	CDD:280934	64/108 (59%)
txnrd2.2	NP_001340325.1	Pyr_redox_dim	31..517	CDD:332164	270/487 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	369	1.000	Domainoid score	I864
eggNOG	1	0.900	-	-		E1_COG1249
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	556	1.000	Inparanoid score	I1082
OMA	1	1.010	-	-		QHG57703
OrthoDB	1	1.010	-	-		D164705at33208
OrthoFinder	1	1.000	-	-		FOG0000578
OrthoInspector	1	1.000	-	-		otm24606
orthoMCL	1	0.900	-	-		OOG6_100956
Panther	1	1.100	-	-	O	PTHR48105
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R529
SonicParanoid	1	1.000	-	-		X1089
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870