DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trxr-2 and TXNRD1

DIOPT Version :9

Sequence 1:	NP_524216.1	Gene:	Trxr-2 / 40475	FlyBaseID:	FBgn0037170	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001087240.1	Gene:	TXNRD1 / 7296	HGNCID:	12437	Length:	649	Species:	Homo sapiens

Alignment Length:	489	Identity:	250/489 - (51%)
Similarity:	332/489 - (67%)	Gaps:	7/489 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 YDYDLVVLGGGSAGLACAKEAAGCGARVLCFDYVKPTPVGTKWGIGGTCVNVGCIPKKLMHQASL 95
            |||||:::||||.|||.|||||..|.:|:..|:|.|||:||:||:||||||||||||||||||:|
Human   161 YDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAAL 225

  Fly    96 LGEAVHEAVAYGWNVDDTNIRPDWRKLVRSVQNHIKSVNWVTRVDLRDKKVEYVNSMATFRDSHT 160
            ||:|:.::..|||.|::| ::.||.:::.:|||||.|:||..||.||:|||.|.|:...|...|.
Human   226 LGQALQDSRNYGWKVEET-VKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHR 289

  Fly   161 IEYVAMPGAEHRQVTSEYVVVAVGGRPRYPDIPGAVELGITSDDIFSYEREPGRTLVVGAGYVGL 225
            |:.....|.| :..::|..::|.|.||||..|||..|..|:|||:||....||:||||||.||.|
Human   290 IKATNNKGKE-KIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVAL 353

  Fly   226 ECACFLKGLGYEPTVMVRSIVLRGFDRQMSELLAAMMTERGIPFLGTTIP---KAVERQADGRLL 287
            |||.||.|:|.:.|||||||:|||||:.|:..:...|.|.||.|:...:|   :.:|....|||.
Human   354 ECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLR 418

  Fly   288 VRYRNTTTQMDGSDVFDTVLWAIGRKGLIEDLNLDAAGVKTHD--DKIVVDAAEATSVPHIFAVG 350
            |..::|.::......::||:.||||......:.|:..|||.::  .||.|...|.|:||:|:|:|
Human   419 VVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIYAIG 483

  Fly   351 DIIYGRPELTPVAILSGRLLARRLFAGSTQLMDYADVATTVFTPLEYSCVGMSEETAIELRGADN 415
            ||:..:.|||||||.:|||||:||:||||...||.:|.|||||||||...|:|||.|:|..|.:|
Human   484 DILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEEN 548

  Fly   416 IEVFHGYYKPTEFFIPQKSVRHCYLKAVAEVSGDQKILGLHYIGPVAGEVIQGFAAALKTGLTVK 480
            |||:|.|:.|.|:.||.:....||.|.:.....:::::|.|.:||.||||.||||||||.|||.|
Human   549 IEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKK 613

  Fly   481 TLLNTVGIHPTTAEEFTRLSITKRSGRDPTPASC 514
            .|.:|:||||..||.||.||:|||||.....|.|
Human   614 QLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGC 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-2	NP_524216.1	NADB_Rossmann	29..>68	CDD:304358	22/36 (61%)
		TGR	31..515	CDD:273624	250/489 (51%)
		NADB_Rossmann	<144..239	CDD:304358	45/94 (48%)
		Pyr_redox	214..288	CDD:278498	39/76 (51%)
		Pyr_redox_dim	388..497	CDD:280934	57/108 (53%)
TXNRD1	NP_001087240.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49
		GRX_GRXh_1_2_like	68..148	CDD:239511
		TGR	161..649	CDD:273624	250/489 (51%)
		Pyr_redox	342..418	CDD:278498	38/75 (51%)
		Pyr_redox_dim	521..631	CDD:280934	58/109 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	128	1.000	Domainoid score	I5308
eggNOG	1	0.900	-	-		E1_COG1249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57703
OrthoDB	1	1.010	-	-		D164705at33208
OrthoFinder	1	1.000	-	-		FOG0000578
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100956
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.730