Protein Alignment Trxr2 and TXNRD1

DIOPT Version :10

• Sequence 1: NP_524216.1
• Gene: Trxr2 / 40475
• FlyBaseID: FBgn0037170
• Length: 516
• Species: Drosophila melanogaster
• Sequence 2: NP_001087240.1
• Gene: TXNRD1 / 7296
• HGNCID: 12437
• Length: 649
• Species: Homo sapiens
• Alignment Length: 489
• Identity: 250/489 - (51%)
• Similarity: 332/489 - (67%)
• Gaps: 7/489 - (1%)

  Fly    31 YDYDLVVLGGGSAGLACAKEAAGCGARVLCFDYVKPTPVGTKWGIGGTCVNVGCIPKKLMHQASL 95
            |||||:::||||.|||.|||||..|.:|:..|:|.|||:||:||:||||||||||||||||||:|
Human   161 YDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAAL 225

  Fly    96 LGEAVHEAVAYGWNVDDTNIRPDWRKLVRSVQNHIKSVNWVTRVDLRDKKVEYVNSMATFRDSHT 160
            ||:|:.::..|||.|::| ::.||.:::.:|||||.|:||..||.||:|||.|.|:...|...|.
Human   226 LGQALQDSRNYGWKVEET-VKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHR 289

  Fly   161 IEYVAMPGAEHRQVTSEYVVVAVGGRPRYPDIPGAVELGITSDDIFSYEREPGRTLVVGAGYVGL 225
            |:.....|.| :..::|..::|.|.||||..|||..|..|:|||:||....||:||||||.||.|
Human   290 IKATNNKGKE-KIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVAL 353

  Fly   226 ECACFLKGLGYEPTVMVRSIVLRGFDRQMSELLAAMMTERGIPFLGTTIP---KAVERQADGRLL 287
            |||.||.|:|.:.|||||||:|||||:.|:..:...|.|.||.|:...:|   :.:|....|||.
Human   354 ECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLR 418

  Fly   288 VRYRNTTTQMDGSDVFDTVLWAIGRKGLIEDLNLDAAGVKTHD--DKIVVDAAEATSVPHIFAVG 350
            |..::|.::......::||:.||||......:.|:..|||.::  .||.|...|.|:||:|:|:|
Human   419 VVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIYAIG 483

  Fly   351 DIIYGRPELTPVAILSGRLLARRLFAGSTQLMDYADVATTVFTPLEYSCVGMSEETAIELRGADN 415
            ||:..:.|||||||.:|||||:||:||||...||.:|.|||||||||...|:|||.|:|..|.:|
Human   484 DILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEEN 548

  Fly   416 IEVFHGYYKPTEFFIPQKSVRHCYLKAVAEVSGDQKILGLHYIGPVAGEVIQGFAAALKTGLTVK 480
            |||:|.|:.|.|:.||.:....||.|.:.....:::::|.|.:||.||||.||||||||.|||.|
Human   549 IEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKK 613

  Fly   481 TLLNTVGIHPTTAEEFTRLSITKRSGRDPTPASC 514
            .|.:|:||||..||.||.||:|||||.....|.|
Human   614 QLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGC 647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trxr2	NP_524216.1	TGR	31..515	CDD:273624	250/489 (51%)
TXNRD1	NP_001087240.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..49
		GRX_GRXh_1_2_like	68..148	CDD:239511
		Required for interaction with ESR1 and ESR2. /evidence=ECO:0000269|PubMed:15199063	145..149
		TGR	161..649	CDD:273624	250/489 (51%)