DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trxr-2 and dldh

DIOPT Version :9

Sequence 1:	NP_524216.1	Gene:	Trxr-2 / 40475	FlyBaseID:	FBgn0037170	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_958914.1	Gene:	dldh / 399479	ZFINID:	ZDB-GENE-040120-4	Length:	507	Species:	Danio rerio

Alignment Length:	501	Identity:	127/501 - (25%)
Similarity:	219/501 - (43%)	Gaps:	44/501 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 RLAASRPRYDYDLVVLGGGSAGLACAKEAAGCGARVLCFDYVKPTPVGTKWGIGGTCVNVGCIPK 87
            |..|.:...|.|:.|:|.|..|...|.:||..|.:.:|        |.....:||||:||||||.
Zfish    31 RTYADKAAIDADVTVVGSGPGGYVAAIKAAQLGFKTVC--------VEKNATLGGTCLNVGCIPS 87

  Fly    88 KLMHQASLLGEAVHEAVAYGWNVDDTNIRPDWRKLVRSVQNHIKSVNWVTRVDLRDKKVEYVNSM 152
            |.:...|.|....|........::...|..:..|::......:|::........:..||.:||..
Zfish    88 KALLNNSYLYHMAHGKDFESRGIEIQGISLNLEKMMAQKSGAVKALTGGIAHLFKQNKVTHVNGF 152

  Fly   153 ATFRDSHTIEYVAMPGAEHRQVTSEYVVVAVGGR-PRYPDIPGAVELGITSDDIFSYEREPGRTL 216
            .|....:.:......|  .:.:.::.:::|.|.. ..:|.|....:..::|....|.:..|...:
Zfish   153 GTITGKNQVTAKTADG--EQVINTKNILIATGSEVTPFPGIEIDEDSVVSSTGALSLKNVPEELI 215

  Fly   217 VVGAGYVGLECACFLKGLGYEPTVM--VRSIVLRGFDRQMSELLAAMMTERGIPF-LGTTIPKAV 278
            |:|||.:|:|.....:.||.:.|.:  :..:...|.|.::|:....::.::|:.| |.|.:..|.
Zfish   216 VIGAGVIGVELGSVWQRLGAKVTAVEFLGHVGGMGIDMEISKNFQRILQKQGLKFKLSTKVMGAT 280

  Fly   279 ERQADGRLLVRYRNTTTQMDGSDVFDTVLWAIGRKGLIEDLNLDAAGVKTHDDK---IVVDAAEA 340
            :| .||::.|.........:.:...|.:|..|||:....:|.|::.|::.  ||   |.|:....
Zfish   281 KR-PDGKIDVAVEAAAGGKNETLTCDVLLVCIGRRPFTGNLGLESVGIEL--DKRGRIPVNGRFQ 342

  Fly   341 TSVPHIFAVGDIIYGRPELTPVAILSGRLLARRLFAGSTQLMDYADVATTVFTPLEYSCVGMSEE 405
            |:||:|:|:||::.| |.|...|...|.:....:..|:..: ||..|.:.::|..|.:.||.:||
Zfish   343 TNVPNIYAIGDVVAG-PMLAHKAEDEGIICVEGMAGGAVHI-DYNCVPSVIYTHPEVAWVGKTEE 405

  Fly   406 TAIELRGADNIEVFHGYYKPTEFFIPQKSVRHCYLKAVAEVSGDQKI---------LGLHYIGPV 461
            ...| .|..        ||..:|.....|    ..|..|:..|..||         ||.|.:|..
Zfish   406 QLKE-EGVP--------YKVGKFPFAANS----RAKTNADTDGLVKILSHKDTDRMLGAHILGSG 457

  Fly   462 AGEVIQGFAAALKTGLTVKTLLNTVGIHPTTAEEFTRLSITKRSGR 507
            |||:|...|.|::.|.:.:.:......|||.:|.|...::....|:
Zfish   458 AGEMINEAALAMEYGASCEDVARVCHAHPTVSEAFREANLAASFGK 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-2	NP_524216.1	NADB_Rossmann	29..>68	CDD:304358	11/38 (29%)
		TGR	31..515	CDD:273624	125/493 (25%)
		NADB_Rossmann	<144..239	CDD:304358	21/95 (22%)
		Pyr_redox	214..288	CDD:278498	20/76 (26%)
		Pyr_redox_dim	388..497	CDD:280934	32/117 (27%)
dldh	NP_958914.1	PRK06327	42..507	CDD:235779	124/490 (25%)
		NADB_Rossmann	44..220	CDD:304358	42/185 (23%)
		Pyr_redox	214..286	CDD:278498	19/72 (26%)
		Glycosyltransferase_GTB_type	<282..376	CDD:299143	28/97 (29%)
		Pyr_redox_dim	388..494	CDD:280934	33/118 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D581771at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820