DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trxr-2 and Trxr-1

DIOPT Version :9

Sequence 1:	NP_524216.1	Gene:	Trxr-2 / 40475	FlyBaseID:	FBgn0037170	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_727251.1	Gene:	Trxr-1 / 31760	FlyBaseID:	FBgn0020653	Length:	596	Species:	Drosophila melanogaster

Alignment Length:	487	Identity:	374/487 - (76%)
Similarity:	428/487 - (87%)	Gaps:	4/487 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 YDYDLVVLGGGSAGLACAKEAAGCGARVLCFDYVKPTP-VGTKWGIGGTCVNVGCIPKKLMHQAS 94
            |||||:|:|||||||||||||...||||.|.|:||||| :|||||:|||||||||||||||||||
  Fly   113 YDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGCIPKKLMHQAS 177

  Fly    95 LLGEAVHEAVAYGWNVDDTNIRPDWRKLVRSVQNHIKSVNWVTRVDLRDKKVEYVNSMATFRDSH 159
            |||||||||.|||||||: .|:|||.|||:||||||||||||||||||||||||:|.:.:|.|||
  Fly   178 LLGEAVHEAAAYGWNVDE-KIKPDWHKLVQSVQNHIKSVNWVTRVDLRDKKVEYINGLGSFVDSH 241

  Fly   160 TIEYVAMPGAEHRQVTSEYVVVAVGGRPRYPDIPGAVELGITSDDIFSYEREPGRTLVVGAGYVG 224
            |:  :|...:..|.:|::..|:||||||||||||||||.||||||:||.:||||:||||||||:|
  Fly   242 TL--LAKLKSGERTITAQTFVIAVGGRPRYPDIPGAVEYGITSDDLFSLDREPGKTLVVGAGYIG 304

  Fly   225 LECACFLKGLGYEPTVMVRSIVLRGFDRQMSELLAAMMTERGIPFLGTTIPKAVERQADGRLLVR 289
            ||||.||||||||||||||||||||||:||:||:||.|.|||||||..|:|.:||:|.||:|||:
  Fly   305 LECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASMEERGIPFLRKTVPLSVEKQDDGKLLVK 369

  Fly   290 YRNTTTQMDGSDVFDTVLWAIGRKGLIEDLNLDAAGVKTHDDKIVVDAAEATSVPHIFAVGDIIY 354
            |:|..|..:..||:||||||||||||::||||..|||....|||.||:.|||:|.:|:|||||||
  Fly   370 YKNVETGEEAEDVYDTVLWAIGRKGLVDDLNLPNAGVTVQKDKIPVDSQEATNVANIYAVGDIIY 434

  Fly   355 GRPELTPVAILSGRLLARRLFAGSTQLMDYADVATTVFTPLEYSCVGMSEETAIELRGADNIEVF 419
            |:|||||||:|:||||||||:.||||.|||.||||||||||||:|||:|||.|::..|||.||||
  Fly   435 GKPELTPVAVLAGRLLARRLYGGSTQRMDYKDVATTVFTPLEYACVGLSEEDAVKQFGADEIEVF 499

  Fly   420 HGYYKPTEFFIPQKSVRHCYLKAVAEVSGDQKILGLHYIGPVAGEVIQGFAAALKTGLTVKTLLN 484
            |||||||||||||||||:||||||||..|||::.|||||||||||||||||||||:|||:.||:|
  Fly   500 HGYYKPTEFFIPQKSVRYCYLKAVAERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLIN 564

  Fly   485 TVGIHPTTAEEFTRLSITKRSGRDPTPASCCS 516
            |||||||||||||||:||||||.|||||||||
  Fly   565 TVGIHPTTAEEFTRLAITKRSGLDPTPASCCS 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-2	NP_524216.1	NADB_Rossmann	29..>68	CDD:304358	28/36 (78%)
		TGR	31..515	CDD:273624	371/484 (77%)
		NADB_Rossmann	<144..239	CDD:304358	64/94 (68%)
		Pyr_redox	214..288	CDD:278498	57/73 (78%)
		Pyr_redox_dim	388..497	CDD:280934	90/108 (83%)
Trxr-1	NP_727251.1	TGR	113..595	CDD:273624	371/484 (77%)
		NADB_Rossmann	115..>150	CDD:304358	26/34 (76%)
		Pyr_redox	294..368	CDD:278498	57/73 (78%)
		Pyr_redox_dim	468..577	CDD:280934	90/108 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45473293
Domainoid	1	1.000	187	1.000	Domainoid score	I973
eggNOG	1	0.900	-	-		E1_COG1249
Homologene	1	1.000	-	-		H4701
Inparanoid	1	1.050	264	1.000	Inparanoid score	I952
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164705at33208
OrthoFinder	1	1.000	-	-		FOG0000578
OrthoInspector	1	1.000	-	-		otm24606
orthoMCL	1	0.900	-	-		OOG6_100956
Panther	1	1.100	-	-	P	PTHR48105
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R529
SonicParanoid	1	1.000	-	-		X1089
	13	12.830