Protein Alignment Trxr2 and GSR

DIOPT Version :10

• Sequence 1: NP_524216.1
• Gene: Trxr2 / 40475
• FlyBaseID: FBgn0037170
• Length: 516
• Species: Drosophila melanogaster
• Sequence 2: NP_000628.2
• Gene: GSR / 2936
• HGNCID: 4623
• Length: 522
• Species: Homo sapiens
• Alignment Length: 484
• Identity: 170/484 - (35%)
• Similarity: 259/484 - (53%)
• Gaps: 44/484 - (9%)

  Fly    33 YDLVVLGGGSAGLACAKEAAGCGARVLCFDYVKPTPVGTKWGIGGTCVNVGCIPKKLMHQASLLG 97
            ||.:|:||||.|||.|:.||..|||....:..|         :|||||||||:|||:|...::..
Human    65 YDYLVIGGGSGGLASARRAAELGARAAVVESHK---------LGGTCVNVGCVPKKVMWNTAVHS 120

  Fly    98 EAVHEAVAYGWNVDDTNIRPDWRKLVRSVQNHIKSVNWVTRVDLRDKKVEYVNSMATFRD--SHT 160
            |.:|:...||:...:...  :||.:......::..:|.:.:.:|....:|.:...|.|..  ..|
Human   121 EFMHDHADYGFPSCEGKF--NWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPT 183

  Fly   161 IEYVAMPGAEHRQVTSEYVVVAVGGRPRYP---DIPGAVELGITSDDIFSYEREPGRTLVVGAGY 222
            ||      ...::.|:.::::|.||.|..|   .|||| .||||||..|..|..|||:::|||||
Human   184 IE------VSGKKYTAPHILIATGGMPSTPHESQIPGA-SLGITSDGFFQLEELPGRSVIVGAGY 241

  Fly   223 VGLECACFLKGLGYEPTVMVR-SIVLRGFDRQMSELLAAMMTERGIPFLGTTIPKAVERQADGRL 286
            :.:|.|..|..||.:.::|:| ..|||.||..:|......:...|:..|..:..|.|::...|..
Human   242 IAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLE 306

  Fly   287 LVRYRNTTTQMDG--------SDVFDTVLWAIGRKGLIEDLNLDAAGVKTHDDK--IVVDAAEAT 341
            :    :..|.:.|        .|| |.:||||||....:||:|:..|::| |||  |:||..:.|
Human   307 V----SMVTAVPGRLPVMTMIPDV-DCLLWAIGRVPNTKDLSLNKLGIQT-DDKGHIIVDEFQNT 365

  Fly   342 SVPHIFAVGDIIYGRPELTPVAILSGRLLARRLFA-GSTQLMDYADVATTVFTPLEYSCVGMSEE 405
            :|..|:||||:. |:..||||||.:||.||.|||. .....:||.::.|.||:......||::|:
Human   366 NVKGIYAVGDVC-GKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTED 429

  Fly   406 TAIELRGADNIEVFHGYYKPTEFFIPQKSVRHCYLKAVAEVSGDQKILGLHYIGPVAGEVIQGFA 470
            .||...|.:|::.:...:.|....:.::..: |.:|.|. .:.::|::|:|..|....|::||||
Human   430 EAIHKYGIENVKTYSTSFTPMYHAVTKRKTK-CVMKMVC-ANKEEKVVGIHMQGLGCDEMLQGFA 492

  Fly   471 AALKTGLTVKTLLNTVGIHPTTAEEFTRL 499
            .|:|.|.|.....|||.||||::||...|
Human   493 VAVKMGATKADFDNTVAIHPTSSEELVTL 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trxr2	NP_524216.1	TGR	31..515	CDD:273624	170/484 (35%)
GSR	NP_000628.2	gluta_reduc_1	63..522	CDD:273614	170/484 (35%)