DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trxr-2 and GSR

DIOPT Version :9

Sequence 1:	NP_524216.1	Gene:	Trxr-2 / 40475	FlyBaseID:	FBgn0037170	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_000628.2	Gene:	GSR / 2936	HGNCID:	4623	Length:	522	Species:	Homo sapiens

Alignment Length:	484	Identity:	170/484 - (35%)
Similarity:	259/484 - (53%)	Gaps:	44/484 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 YDLVVLGGGSAGLACAKEAAGCGARVLCFDYVKPTPVGTKWGIGGTCVNVGCIPKKLMHQASLLG 97
            ||.:|:||||.|||.|:.||..|||....:..|         :|||||||||:|||:|...::..
Human    65 YDYLVIGGGSGGLASARRAAELGARAAVVESHK---------LGGTCVNVGCVPKKVMWNTAVHS 120

  Fly    98 EAVHEAVAYGWNVDDTNIRPDWRKLVRSVQNHIKSVNWVTRVDLRDKKVEYVNSMATFRD--SHT 160
            |.:|:...||:...:...  :||.:......::..:|.:.:.:|....:|.:...|.|..  ..|
Human   121 EFMHDHADYGFPSCEGKF--NWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPT 183

  Fly   161 IEYVAMPGAEHRQVTSEYVVVAVGGRPRYP---DIPGAVELGITSDDIFSYEREPGRTLVVGAGY 222
            ||      ...::.|:.::::|.||.|..|   .|||| .||||||..|..|..|||:::|||||
Human   184 IE------VSGKKYTAPHILIATGGMPSTPHESQIPGA-SLGITSDGFFQLEELPGRSVIVGAGY 241

  Fly   223 VGLECACFLKGLGYEPTVMVR-SIVLRGFDRQMSELLAAMMTERGIPFLGTTIPKAVERQADGRL 286
            :.:|.|..|..||.:.::|:| ..|||.||..:|......:...|:..|..:..|.|::...|..
Human   242 IAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLE 306

  Fly   287 LVRYRNTTTQMDG--------SDVFDTVLWAIGRKGLIEDLNLDAAGVKTHDDK--IVVDAAEAT 341
            :    :..|.:.|        .|| |.:||||||....:||:|:..|::| |||  |:||..:.|
Human   307 V----SMVTAVPGRLPVMTMIPDV-DCLLWAIGRVPNTKDLSLNKLGIQT-DDKGHIIVDEFQNT 365

  Fly   342 SVPHIFAVGDIIYGRPELTPVAILSGRLLARRLFA-GSTQLMDYADVATTVFTPLEYSCVGMSEE 405
            :|..|:||||:. |:..||||||.:||.||.|||. .....:||.::.|.||:......||::|:
Human   366 NVKGIYAVGDVC-GKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTED 429

  Fly   406 TAIELRGADNIEVFHGYYKPTEFFIPQKSVRHCYLKAVAEVSGDQKILGLHYIGPVAGEVIQGFA 470
            .||...|.:|::.:...:.|....:.::..: |.:|.|. .:.::|::|:|..|....|::||||
Human   430 EAIHKYGIENVKTYSTSFTPMYHAVTKRKTK-CVMKMVC-ANKEEKVVGIHMQGLGCDEMLQGFA 492

  Fly   471 AALKTGLTVKTLLNTVGIHPTTAEEFTRL 499
            .|:|.|.|.....|||.||||::||...|
Human   493 VAVKMGATKADFDNTVAIHPTSSEELVTL 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-2	NP_524216.1	NADB_Rossmann	29..>68	CDD:304358	17/34 (50%)
		TGR	31..515	CDD:273624	170/484 (35%)
		NADB_Rossmann	<144..239	CDD:304358	37/99 (37%)
		Pyr_redox	214..288	CDD:278498	24/74 (32%)
		Pyr_redox_dim	388..497	CDD:280934	36/108 (33%)
GSR	NP_000628.2	gluta_reduc_1	63..522	CDD:273614	170/484 (35%)
		Pyr_redox	233..307	CDD:278498	24/73 (33%)
		Pyr_redox_dim	412..520	CDD:280934	36/109 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S706
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164705at33208
OrthoFinder	1	1.000	-	-		FOG0000578
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R529
SonicParanoid	1	1.000	-	-		X1089
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.800