DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trxr-2 and trxr-1

DIOPT Version :9

Sequence 1:	NP_524216.1	Gene:	Trxr-2 / 40475	FlyBaseID:	FBgn0037170	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001294239.1	Gene:	trxr-1 / 177466	WormBaseID:	WBGene00015553	Length:	667	Species:	Caenorhabditis elegans

Alignment Length:	524	Identity:	229/524 - (43%)
Similarity:	324/524 - (61%)	Gaps:	23/524 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IKFLRSSTHNALRSSLGWCRLAASRPRYDYDLVVLGGGSAGLACAKEAAGCGARVLCFDYVKPTP 68
            :|.|::...:.|:.   |.|      .:.|||:|:||||.|||.||||:..|.:|.|.|:|||:|
Worm   153 LKELKALKQDYLKE---WLR------DHTYDLIVIGGGSGGLAAAKEASRLGKKVACLDFVKPSP 208

  Fly    69 VGTKWGIGGTCVNVGCIPKKLMHQASLLGEAVHEAVAYGWNVDDTNIRPDWRKLVRSVQNHIKSV 133
            .||.||:||||||||||||||||||||||.::|:|..|||.:.:..:...|..|..|||:||.|:
Worm   209 QGTSWGLGGTCVNVGCIPKKLMHQASLLGHSIHDAKKYGWKLPEGKVEHQWNHLRDSVQDHIASL 273

  Fly   134 NWVTRVDLRDKKVEYVNSMATFRDSHTIEYVAMPGAEHRQVTSEYVVVAVGGRPRYPDIPGAVEL 198
            ||..||.||:|.|.|:||...|.....|. ......:..::|::..:::.|.||:||:|||..|.
Worm   274 NWGYRVQLREKTVTYINSYGEFTGPFEIS-ATNKKKKVEKLTADRFLISTGLRPKYPEIPGVKEY 337

  Fly   199 GITSDDIFSYEREPGRTLVVGAGYVGLECACFLKGLGYEPTVMVRSIVLRGFDRQMSELLAAMMT 263
            .|||||:|.....||:||.|||.||.||||.||.|.|::.|||||||:|||||:.|:|.:...|.
Worm   338 TITSDDLFQLPYSPGKTLCVGASYVSLECAGFLHGFGFDVTVMVRSILLRGFDQDMAERIRKHMI 402

  Fly   264 ERGIPFLGTTIPKAVER------QADGRLLV----RYRNTTTQMDGSDVFDTVLWAIGRKGLIED 318
            ..|:.| ...:|..:|:      :..|:..|    :...|....:.|:.::|:|.||||:.:.:|
Worm   403 AYGMKF-EAGVPTRIEQIDEKTDEKAGKYRVFWPKKNEETGEMQEVSEEYNTILMAIGREAVTDD 466

  Fly   319 LNLDAAGVKTHDDKIVVDAAE-ATSVPHIFAVGDIIYGRPELTPVAILSGRLLARRLFAGSTQLM 382
            :.|...||:....|.|:...| :|::|.::|:||::.|.||||||||.:||:|.||:|.|:.:|.
Worm   467 VGLTTIGVERAKSKKVLGRREQSTTIPWVYAIGDVLEGTPELTPVAIQAGRVLMRRIFDGANELT 531

  Fly   383 DYADVATTVFTPLEYSCVGMSEETAIELRGADNIEVFHGYYKPTEFFIPQKSVR-HCYLKAVAEV 446
            :|..:.|||||||||.|.|:|||.|:...|.|||.::|..:.|.|:.|.::..: |||||.:...
Worm   532 EYDQIPTTVFTPLEYGCCGLSEEDAMMKYGKDNIIIYHNVFNPLEYTISERMDKDHCYLKMICLR 596

  Fly   447 SGDQKILGLHYIGPVAGEVIQGFAAALKTGLTVKTLLNTVGIHPTTAEEFTRLSITKRSGRDPTP 511
            :.::|::|.|.:.|.||||.|||..|||...........:|||||.||.||.|::.|:.|.:...
Worm   597 NEEEKVVGFHILTPNAGEVTQGFGIALKLAAKKADFDRLIGIHPTVAENFTTLTLEKKEGDEELQ 661

  Fly   512 ASCC 515
            ||.|
Worm   662 ASGC 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-2	NP_524216.1	NADB_Rossmann	29..>68	CDD:304358	22/38 (58%)
		TGR	31..515	CDD:273624	223/495 (45%)
		NADB_Rossmann	<144..239	CDD:304358	40/94 (43%)
		Pyr_redox	214..288	CDD:278498	35/79 (44%)
		Pyr_redox_dim	388..497	CDD:280934	49/109 (45%)
trxr-1	NP_001294239.1	TGR	173..667	CDD:273624	224/495 (45%)
		Pyr_redox	353..426	CDD:278498	34/73 (47%)
		Pyr_redox_dim	537..648	CDD:280934	50/110 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160168012
Domainoid	1	1.000	341	1.000	Domainoid score	I576
eggNOG	1	0.900	-	-		E1_COG1249
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	470	1.000	Inparanoid score	I839
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57703
OrthoDB	1	1.010	-	-		D164705at33208
OrthoFinder	1	1.000	-	-		FOG0000578
OrthoInspector	1	1.000	-	-		otm14752
orthoMCL	1	0.900	-	-		OOG6_100956
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.670