DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trxr-2 and txnrd1

DIOPT Version :9

Sequence 1:	NP_524216.1	Gene:	Trxr-2 / 40475	FlyBaseID:	FBgn0037170	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001243400.1	Gene:	txnrd1 / 100495372	XenbaseID:	XB-GENE-956002	Length:	653	Species:	Xenopus tropicalis

Alignment Length:	516	Identity:	248/516 - (48%)
Similarity:	331/516 - (64%)	Gaps:	14/516 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LRSSTHNALRSSLGWCRLAASRPRYDYDLVVLGGGSAGLACAKEAAGCGARVLCFDYVKPTPVGT 71
            |:.|..|..:..|........|..|||||:|:||||.|||.:||||..|.:||..|:|.|||:||
Frog   142 LKLSKENLFQKLLETKEDNPDRSGYDYDLIVIGGGSGGLAASKEAANYGKKVLVLDFVTPTPLGT 206

  Fly    72 KWGIGGTCVNVGCIPKKLMHQASLLGEAVHEAVAYGWNVDDTNIRPDWRKLVRSVQNHIKSVNWV 136
            |||:||||||||||||||||||:||.:|:.::..|||.::| ||:.:|..:..||.|:|.|:|:.
Frog   207 KWGLGGTCVNVGCIPKKLMHQAALLRQALKDSQKYGWQIED-NIQHNWEIMTDSVLNYIGSLNFN 270

  Fly   137 TRVDLRDKKVEYVNSMATFRDSHTIEYVAMPGAEHRQVTSEYVVVAVGGRPRYPDIPGAVELGIT 201
            .||.|....|:|.|....|.:.|||:.....|.| :..|:|..::|.|.||||..|||..|..||
Frog   271 YRVSLMQNNVKYENGYGEFVEPHTIKSTNSRGKE-KYFTAEKFLIATGERPRYLGIPGDKEYCIT 334

  Fly   202 SDDIFSYEREPGRTLVVGAGYVGLECACFLKGLGYEPTVMVRSIVLRGFDRQMSELLAAMMTERG 266
            |||:||....||:||||||.||.||||.||.|||.:.|||||||:|||||:||:.::...|.|.|
Frog   335 SDDLFSLPYCPGKTLVVGASYVALECAGFLAGLGLDVTVMVRSILLRGFDQQMANMIGEYMEEHG 399

  Fly   267 IPFLGTTIP---KAVERQADGRLLVRYRNTTTQMDGSDV---FDTVLWAIGRKGLIEDLNLDAAG 325
            :.|:...:|   :.:|....|||.|    |:...||::.   ::|||.||||.....::.|:..|
Frog   400 VKFIKQCVPTKIEQIEAGTPGRLKV----TSQASDGAETTEEYNTVLLAIGRDACTRNIGLEIPG 460

  Fly   326 VKTHD--DKIVVDAAEATSVPHIFAVGDIIYGRPELTPVAILSGRLLARRLFAGSTQLMDYADVA 388
            ||.::  .||.|:..|.|:||:|:|:||::..:.|||||||.:||||||||:..||...||.:|.
Frog   461 VKINEKTGKIPVNDEEQTNVPYIYAIGDVLQDKLELTPVAIQAGRLLARRLYGDSTVKCDYVNVP 525

  Fly   389 TTVFTPLEYSCVGMSEETAIELRGADNIEVFHGYYKPTEFFIPQKSVRHCYLKAVAEVSGDQKIL 453
            |||||||||...|:|||.||.....:||||:|.|:.|.|:.:|.:....||.|.:..:....:::
Frog   526 TTVFTPLEYGACGLSEEHAIRQYEEENIEVYHSYFWPLEWTVPARDNNKCYAKIICNLKDKGRVV 590

  Fly   454 GLHYIGPVAGEVIQGFAAALKTGLTVKTLLNTVGIHPTTAEEFTRLSITKRSGRDPTPASC 514
            |.|.:.|.|||:.||||.|:|.|||...|.||:||||..||.||.|::|||||.:...:.|
Frog   591 GFHVLSPNAGEITQGFAVAIKCGLTKDQLDNTIGIHPVCAEIFTTLTVTKRSGGNILQSGC 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-2	NP_524216.1	NADB_Rossmann	29..>68	CDD:304358	23/38 (61%)
		TGR	31..515	CDD:273624	243/492 (49%)
		NADB_Rossmann	<144..239	CDD:304358	47/94 (50%)
		Pyr_redox	214..288	CDD:278498	40/76 (53%)
		Pyr_redox_dim	388..497	CDD:280934	51/108 (47%)
txnrd1	NP_001243400.1	Thioredoxin_like	73..153	CDD:294274	3/10 (30%)
		TGR	166..653	CDD:273624	243/492 (49%)
		Pyr_redox	347..423	CDD:278498	39/75 (52%)
		Pyr_redox_dim	525..635	CDD:280934	52/109 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164705at33208
OrthoFinder	1	1.000	-	-		FOG0000578
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010