Protein Alignment Ten-m and tenm1

DIOPT Version :10

• Sequence 1: NP_001262211.1
• Gene: Ten-m / 40464
• FlyBaseID: FBgn0004449
• Length: 3349
• Species: Drosophila melanogaster
• Sequence 2: XP_691552.5
• Gene: tenm1 / 563094
• ZFINID: ZDB-GENE-060531-26
• Length: 2721
• Species: Danio rerio
• Alignment Length: 2840
• Identity: 880/2840 - (30%)
• Similarity: 1376/2840 - (48%)
• Gaps: 385/2840 - (13%)

  Fly   686 DLMMNDASHYEDIDIVKLDGLTISHEEEIYKTADKENMAPKNQPSQHIDRSQNEVLKGHQQGDEK 750
            :|..:.:|..||      ..|...|..|.:..||.|       |.:....:.::|        .:
Zfish    17 ELSYSSSSEEED------GNLHHKHYRETHIRADYE-------PDRRFTYNSHKV--------RR 60

  Fly   751 QPQLEPLKPYVSERVDLPGKRIF---------LNLTIATDEGSDSVYTLHVEVPTGGGP-HFIKE 805
            :|..:|.|.:..     |.:.:|         .|..:|...|..:......|...|..| |.::
Zfish    61 KPLEQPQKDFSD-----PSQTVFPDFQTELHAANQELAYPGGVSAGVPSDPESEGGASPDHALR- 119

  Fly   806 VLTHEKPTAQADSCV------------------------------------PEPPPRMPDCPCSC 834
             |..::..::..||:                                    |.|||..|...|:|
Zfish   120 -LWMQEVKSEHSSCLSSRANSVLSLTDTEQERKSEPENDLPSSPVAQFTFRPLPPPPPPPHACTC 183

  Fly   835 L-PPPAPIYLDDTVDIDSAPPAKTVTTSTISAPINPFHSEEEDDEDGVRDEEQTP---------- 888
            . |.|||:             .:.|..||:.|...|..|..:..:|   |..||.
Zfish   184 ARPAPAPL-------------PEVVQRSTLPARCQPLDSGNKAGQD---DNGQTHNTWALNSNIP 232

  Fly   889 ---------------------------SSSTATN-----LPSTEIDNHIAAFTEP---------A 912
                                       :|||..:     ||.|.:...:.:|::|         |
Zfish   233 LETRHFLFKHGSGSSAIFNAANQNYPLTSSTVYSPPPRPLPRTTLSRPLFSFSKPYRCCNWKCTA 297

  Fly   913 VGAGGVPFACPDVMPVLI-----------------------------LEGAR-TFPARSFPPDGT 947
            :.|..:......::..:|                             |.||. ||.....|...|
Zfish   298 LSASAITLTLALLLTYIIVVHLLGLPWHLKRVEGELYENGMSKEDQPLPGADFTFTPVHLPGLNT 362

  Fly   948 T--------------FGQITLGQKLTKEIQPYSYWNMQFYQSEPAYVKFDYTIPRGASIGVYGRR 998
            |              .|::.:|.:|.:.|.|..:|........|.||||:.::.|.|.:|:||||
Zfish   363 TQPDKEVIQRGRVIERGEVAVGTQLVQAIPPGLFWRFHITVHHPEYVKFNISLTRDALLGIYGRR 427

  Fly   999 NALPTHTQYHFKEVLSG---FSASTRTA-------RAAHLSITREV--TRYMEPGHWFVSLYNDD 1051
            |..|||||:.|.::|.|   ....:|..       |:..:|..:|.  ..|::.|.|:::.|||.
Zfish   428 NIPPTHTQFDFVKLLDGRQLIKQDSRNVKSPIAPPRSLLMSALQETGFVEYLDVGTWYLAFYNDG 492

  Fly  1052 GDVQELTFYAAVAEDMTQNCPNGCSGNGQCLLGHCQCNPGFGGDDCSESVCPVLCSQHGEYTNGE 1116
            ..::::..|:...|.: ..|...|:|||:|:.|||.|..||.|.|||:..||||||.:|:|..|.
Zfish   493 RKMEQVVVYSTPIETI-DGCSTNCNGNGECVAGHCHCFTGFLGPDCSKDSCPVLCSGNGDYEKGV 556

  Fly  1117 CICNPGWKGKECSLRHDECEVADCSGHGHCVSGKCQCMRGYKGKFCEEVDCPHPNCSGHGFCADG 1181
            |:|:.||||.||.:...:|....||.:|.||:|.|.|...:||..||:|||..|.|||.|.|..|
Zfish   557 CVCHTGWKGAECEVEEGQCIDPTCSNNGECVNGACVCAPAFKGDNCEQVDCKDPLCSGRGVCVRG 621

  Fly  1182 TCICKKGWKGPDCATMDQDAL-QCLPDCSGHGTFDLDTQTCTCEAKWSGDDCSKELCDLDCGQHG 1245
            .|:|..||.|..|.|    || .|...||||||:...|..|.||..|||:||:.|:|.:.|..|.
Zfish   622 ECVCSAGWGGESCET----ALPACKEQCSGHGTYQTQTGGCVCEQGWSGEDCAIEVCPVPCSPHS 682

  Fly  1246 RCEGDACACDPEWGGEYCNTRLCDVRCNEHGQCKNGTCLCVTGWNGKHCTI----------EGCP 1300
            .|....|.|:..|.|..|:.:.|...|.|||:|::|.|:|..||.|:||||          :.||
Zfish   683 VCVAGRCQCEEGWEGTTCDKQPCHPICEEHGECRDGQCVCQPGWEGEHCTIAAHYLDLFDKDACP 747

  Fly  1301 NSCAGHGQCRVSGEGQWECRCYEGWDGPDCGIALELNCGDSKDNDKDGLVDCEDPECCASHVCKT 1365
            ..|.|:|:|.:...| |.|.|..||.||.|.:.:|..|.||||||.|||:||.||:||:..||.:
Zfish   748 GLCNGNGRCTLEQSG-WHCVCQSGWSGPGCNVVMETECNDSKDNDSDGLMDCVDPDCCSQQVCAS 811

  Fly  1366 SQLCVSAPKPIDVLLRKQPPAIT---ASFFERMKFLIDESSLQNY-AKLETFNESIFWNYFNASR 1426
            :.||..:|.|.|::.:......|   ..||||::|||...|.... ..|.          |::||
Zfish   812 APLCQGSPDPRDIIQQSHTSYETRPSRQFFERVRFLIGRDSTHILPGDLP----------FDSSR 866

  Fly  1427 SAVIRGRVVTSLGMGLVGVRVSTTTLLE-GFTLTRDDGWFDLMVNGGGAVTLQFGRAPFRPQSRI 1490
            ..||||:|:.|.|..||||.|:.....| |:||:|.||.|||:..||.:|:|.|.||||..|.|.
Zfish   867 VCVIRGQVLASDGTPLVGVNVTFQHNPEYGYTLSRQDGSFDLLAVGGISVSLVFQRAPFLSQIRS 931

  Fly  1491 VQVPWNEVVIIDLVVMSMSEEKGLAVTTTHTCFAHDYDLMKP--VVLASWKHGFQGACPDRSAIL 1553
            |.:|||:.:::|.|.|..:|.|      |..|...  :|:.|  |||::....|...|.:|.|:|
Zfish   932 VWLPWNQFMVLDRVFMERTESK------TPVCDLK--NLISPHAVVLSAPLPRFAADCEERGAVL 988

  Fly  1554 AESQVIQESLQIPGTGLNLVYHSSRAAGYLSTIKLQLTPDVIPTSLHLIHLRITIEGILFERIFE 1618
            .|.|.:||.:.||.|.|.|.|.||||.||.|.:::.||...:|..|..:||.:.::|....:.|.
Zfish   989 PELQAVQEEVVIPATVLKLSYLSSRAPGYRSLLRVVLTHSTLPLGLAKVHLSVAVQGRQLLKSFP 1053

  Fly  1619 ADPGIKFTYAWNRLNIYRQRVYGVTTAVVKVGYQYTDCTDIV-WDIQTTKLSGHDMSISEVGGWN 1682
            |.|.:.:.::||:.:||.|:|.|:..|.|.|||:|..|.|:| |:.:..:|.|.::..|.:|||.
Zfish  1054 AAPNLIYVFSWNKTDIYGQQVTGLVQAHVSVGYEYESCLDVVLWEKRVAQLQGFELMPSNLGGWT 1118

  Fly  1683 LDIHHRYNFHEGILQKGDGSNIYLRNKPRIILTTMGDGHQRPLECPDCDGQATKQRLLAPVALAA 1747
            |:.||..|...|||.||:|.|:::..:|.:|.|.||.|..|.:.||:|:|.|.:|:|.||:|||.
Zfish  1119 LNHHHVLNLESGILHKGNGENVFISQQPLVISTVMGTGVVRAIPCPNCNGPAVEQKLFAPIALAC 1183

  Fly  1748 APDGSLFVGDFNYIRRIMTDGSIRTVVKL------NATRVSYRYHMALSPLDGTLYVSDPESHQI 1806
            ..|||::||||||||||:.:|...::::|      :::..:::|::::.|:..:||:||..|.::
Zfish  1184 GSDGSVYVGDFNYIRRILPNGFAISILELRNRDIRHSSSPAHKYYLSMDPVRESLYLSDTSSGKL 1248

  Fly  1807 IRVRDTNDYSQPELNWEAVVGSGERCLPGDEAHCGDGALAKDAKLAYPKGIAISSDNILYFADGT 1871
            .|::...:......|.|.|.||||:|.|.....||||..|.:|.|:.|:|||:.....:||.||:
Zfish  1249 YRLKTLTEPKDLSRNVEVVAGSGEQCTPFHPNQCGDGGKATEAALSNPRGIAVDKHGFIYFVDGS 1313

  Fly  1872 NIRMVDRDGIVSTLIGNHMHKSHWKPIPCEGTLKLEEMHLRWPTELAVSPMDNTLHIIDDHMILR 1936
            .||.:|..|:::|:||::...|. :||.|:..:.:.::.|.|||:|||||:||:|:::|::::|:
Zfish  1314 TIRKIDDKGVITTIIGSNGLTSS-QPISCDSRMDISQVRLEWPTDLAVSPLDNSLYVLDNNLVLQ 1377

  Fly  1937 MTPDGRVRVISGRPLHCATAS--TAYDTDLATHATLVMPQSIAFGPLGELYVAESDSQRINRVRV 1999
            ::...:|||::|||:||..||  .......|..:.|...::||....|.||:||:|.::.:||:.
Zfish  1378 VSESQQVRVVAGRPIHCPMASIEPVLLGKTAVRSVLEGAKAIAVSHQGTLYIAETDDRKHSRVQE 1442

  Fly  2000 IGTDGRIAPFAGAESKCNC-LERGCDCFEAEHYLATSAKFNTIAALAVTPDSHVHIADQANYRIR 2063
            :.|:|.:...|||.|:|:| ::..|:||..:...|..||..:.::|||:|:..:.|||..|.|||
Zfish  1443 VSTNGEMVIIAGATSECDCKIDPNCECFSGDGGYARDAKLKSPSSLAVSPNGSLCIADLGNVRIR 1507

  Fly  2064 SVMSSIPEASPSREYEIYAPDMQEIYIFNRFGQHVSTRNILTGETTYVFTYNVNTSNGKLSTVTD 2128
            .:.::.|:.:|...||:.:...||:|:|:..|.|:.||:::||:....|||   |..|.||::.:
Zfish  1508 RLTANHPQLNPEGLYELASVADQELYLFSPNGTHLFTRSLVTGDYLLNFTY---TPEGHLSSIAN 1569

  Fly  2129 AAGNKVFLLRDYTSQVNSIENTKGQKCRLRMTRMKMLHELSTPDNYNVTYEYHGPTGLLRTKLDS 2193
            ..|....|.||.......:....||...|.::...||..:|...:......|:|.||||.|..:.
Zfish  1570 REGTIAQLRRDANGVPLWLVAPGGQVYWLTISNAGMLKRISALAHDLAQLSYYGNTGLLATISNE 1634

  Fly  2194 TGRSYVYNYDEFGRLTSAVTPTGRVIELSFDLSVKGAQVKVSENAQKEMSLLI------QGATVI 2252
            .|.:.||.|:..|.|.:...|||.|  .||..:::.| |:|...|....:.:|      ......
Zfish  1635 NGWTSVYEYNSDGHLINVTLPTGEV--SSFHGNMEKA-VRVEATASNRENFIIITNHSADNTMYT 1696

  Fly  2253 VRNGAAESRTTVDMDGSTTSITPWGHNLQMEVAPYTILAEQSPLL-----GESYPVPAKQRTEIA 2312
            :|...:.|...|..|||.......|.::.:...|    |..|.||     |..:|...:....:.
Zfish  1697 LRQAHSVSVYGVRDDGSLWVTYASGMDVSLSTEP----AVASGLLAGASAGLVHPTVGRCNITLP 1757

  Fly  2313 GDLANR-FEWRYFVRRQQPLQAGKQSKGPPRPVTEVGRKLRVNGDNVLTLEYDRETQSVVVMVDD 2376
            |:.|:. .|||         |..:|:||   ..|...|:||.:..|||:::|.:|::...:..|.
Zfish  1758 GEPAHSLIEWR---------QRREQAKG---NYTAYERRLRAHNRNVLSIDYSQESRVGKIYDDH 1810

  Fly  2377 KQELLNVTYDRTSRPISFRPQSGDYADVDLEYDRFGRLVSWKWGVLQEAYSFDRNGRLNEIKYGD 2441
            ::..|.|.||...||:.:.|..  |..|.:.|...|.:...:.|...|...:| |||:....:.:
Zfish  1811 RKFTLRVQYDDKGRPVLWTPSK--YNQVRVSYSSEGLVTGIQRGNWTERRDYD-NGRIITRTWAN 1872

  Fly  2442 GSTMVYAFKDMFGSLPLKVTTPRRSDYLLQYDDAGALQSLTTPRGHIHAFSLQTSL--GFFKYQY 2504
            |....|.|.:.  |:.|.:.:.||  |..:||....|.|:|.|....|  ||||||  |:::..|
Zfish  1873 GKIWSYTFLEK--SVQLLLHSQRR--YTFEYDQTDCLLSVTLPSMVRH--SLQTSLSVGYYRNTY 1931

  Fly  2505 YSPIN-RHPFEILYNDEGQILAKIHPHQSGKVAFVHDTAGRLETILAGLSSTHYTYQDTTSLVKS 2568
            ..|.: ...|...|..:|::|..::.....:|.:.:....||..||...:...:||.:.|..||:
Zfish  1932 TPPDSPTSSFTQDYAHDGRLLQSLYLGTGRRVIYKYSRVARLAEILYDSTLVTFTYDEATGAVKT 1996

  Fly  2569 VEVQEPGFELRREFKYHAGILKDEKLRFGSKNSLASARYKYAYDGNARLSGIEMAIDDKELPTTR 2633
            :.:...||.....::....::..:..|| |:..|.:||:.|:|: |.|::.::..|::..||...
Zfish  1997 IHLMHEGFVCTIRYRQTGPLVSRQIYRF-SEEGLVNARFDYSYN-NFRVTSMQAMINETPLPIDL 2059

  Fly  2634 YKYSQNLGQLE-------VVQDLK--ITRNAFNRTVIQDSAKQFFAIVDYDQHGRVKSVLMNVKN 2689
            |:|....|::|       :..||.  ||.:|...|.|            ::.:|:|..|...:..
Zfish  2060 YRYVDVSGRIEQFGKFSVINYDLNQVITTHAMKHTKI------------FNPNGQVIEVQYEILK 2112

  Fly  2690 IDVFRLELDYDLRNRIKSQKTTFGRSTAFDK--INYNADGHV--VEVLGTNNWKYLFDENGNTVG 2750
            ...:.:.|.||...|:.:.....|..:...:  ..|:|||.:  |.:.....|:|.:|.||| :.
Zfish  2113 SIAYWMTLQYDSMGRVTNCDIRIGVDSNITRYAYEYDADGQLQTVAINDRPQWRYSYDLNGN-IN 2176

  Fly  2751 VVDQGEKFN---LGYDIGDRVIKVGDVEFNNYDARGFVVKRGEQKYRYNNRGQLIHSFERERFQS 2812
            ::..|....   |.||:.||:.::|::::.. |..||:..||...:.|.:.|.|:.:::|:..|.
Zfish  2177 LLSHGNSARLTPLRYDLRDRITRLGEIQYRT-DEDGFLRLRGNLLFDYGSNGLLMGAYDRDSEQR 2240

  Fly  2813 -WYYYDDRSRLVAWHDNKGNTTQYYYANPRTPHLVTHVHFPKISRTMKLFYDDRDMLIALE-HED 2875
             ||.||...|.||...:.|...|::||:...|..|||::....:....|:||.:..|||:| ...
Zfish  2241 VWYRYDGLGRRVASRSSDGAQLQFFYADLMEPTRVTHLYNHSSAEITSLYYDLQGHLIAMEMSSG 2305

  Fly  2876 QRYYVATDQNGSPLAFFDQNGSIVKEMKRTPFGRIIKDTKPEFFVPIDFHGGLIDPHTKLVYTEQ 2940
            :.:|:|.|..|:|||.|...|.:|||::.||:|.:.:|:.|.|.:...|.|||.||.|:||:..:
Zfish  2306 EEFYIACDNAGTPLAVFSSRGHVVKEVRYTPYGDVYRDSNPTFSLIFGFQGGLYDPFTRLVHLGR 2370

  Fly  2941 RQYDPHVGQWMTP---LWETLATEMSHPTDVFIYRYHNNDPINPNKP-QNYMIDLDSWLQLFGYD 3001
            |.||...|:|.||   ||..|:.   :|....:|.:.||.|:...:. ..:..|:.|||||||:.
Zfish  2371 RDYDVVAGRWTTPNHELWAELSV---NPKPFNLYAFKNNYPLGHLQDITKFTTDISSWLQLFGFQ 2432

  Fly  3002 LNNMQSSRYTKLAQYTPQ------ASIKSNTLAPDFGVISGLECIVEKTSEKFSDFDFVPKPLLK 3060
            |:|:.........:.|.|      ..|::.|.... .::.|::|.::|..:.|...|.:|
Zfish  2433 LHNVVPGFPKPKVENTEQTYEMMATQIRTQTWDTS-KIVLGIQCDLQKNLKNFISLDRLP----- 2491

  Fly  3061 MEPK------MRNLLPRVSYRRGVFGEGVLLSRIGGRALVSVVDGSNSVVQDVVSSVFNNSYFL- 3118
            |.|.      .:...|..|....:||:||..:...|.....:: |..|.....|::|.|::.:|
Zfish  2492 MTPANGKIGGRQGRRPIFSALSSIFGKGVKFAIRDGVVATEII-GVASEDSRRVAAVLNSAIYLR 2555

  Fly  3119 DLHFSIHDQDVFYFVKDNVLKLRDDNEELRRLGG-----------MFNISTHEISDHGGSAAKEL 3172
            .|||::..:|..||.|...|:     .:|...||           ..|:|..:||...|.   |:
Zfish  2556 GLHFTVEGRDTHYFTKAGPLE-----ADLGVAGGGAGGGVRVLENGVNVSVSQISAMVGG---EM 2612

  Fly  3173 RLHGPDAVV-------IIKYGVDPEQERHRILKHAHKRAVERAWELEKQLVAAGFQGRGDWTEEE 3230
            |... |.|:       .|:||..||:||.|:|..|..|||:.||..|::.|..|..|...||::|
Zfish  2613 RRFA-DIVLQQGALSFNIRYGASPEEERTRVLDAARIRAVQGAWLREQKRVLEGDGGSLAWTDKE 2676

  Fly  3231 KEELVQHGDVDGWNGIDIHSIHKYPQLADDPGNVAFQRDAKRKRR 3275
            |:||:..|.|.|::|.....:.::|:|||.|.|:...|..:..||
Zfish  2677 KDELIAEGHVSGYDGFYALPVEQHPELADSPFNIHLIRHVETGRR 2721

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ten-m	NP_001262211.1	EGF_Tenascin	1071..1098	CDD:480934	14/26 (54%)
		EGF_2	1139..1162	CDD:400365	10/22 (45%)
		DUF5885	<1181..1229	CDD:437064	22/48 (46%)
		EGF_2	1272..1294	CDD:400365	11/21 (52%)
		acid_disulf_rpt	1337..1363	CDD:411265	16/25 (64%)
		NHL	1750..2065	CDD:302697	119/323 (37%)
		NHL repeat	1784..1830	CDD:271323	13/45 (29%)
		NHL repeat	1854..1888	CDD:271323	14/33 (42%)
		NHL repeat	1911..1950	CDD:271323	18/38 (47%)
		NHL repeat	1972..2005	CDD:271323	11/32 (34%)
		NHL repeat	2039..2065	CDD:271323	11/25 (44%)
		RHS_repeat	2183..2217	CDD:461685	13/33 (39%)
		RhsA	<2248..2980	CDD:442442	214/761 (28%)
		Tox-GHH	3191..3268	CDD:464783	30/76 (39%)
tenm1	XP_691552.5	Ten_N	34..294	CDD:461932	51/297 (17%)
		EGF_2	515..537	CDD:400365	12/21 (57%)
		I-EGF_1	<546..563	CDD:465729	7/16 (44%)
		C_rich_MXAN6577	<579..689	CDD:469225	52/113 (46%)
		DUF5885	<621..666	CDD:437064	22/48 (46%)
		DSL	691..734	CDD:473190	19/42 (45%)
		EGF_CA	742..776	CDD:238011	14/34 (41%)
		acid_disulf_rpt	780..809	CDD:411265	17/28 (61%)
		NHL	1149..1509	CDD:302697	137/360 (38%)
		NHL repeat	1178..1213	CDD:271320	18/34 (53%)
		NHL repeat	1229..1272	CDD:271320	12/42 (29%)
		NHL repeat	1296..1334	CDD:271320	15/37 (41%)
		NHL repeat	1352..1391	CDD:271320	18/38 (47%)
		NHL repeat	1415..1448	CDD:271320	11/32 (34%)
		NHL repeat	1483..1509	CDD:271320	11/25 (44%)
		RhsA	1548..2411	CDD:442442	257/912 (28%)
		Tox-GHH	2637..2714	CDD:464783	30/76 (39%)