Protein Alignment Hem and Nckap1

DIOPT Version :10

• Sequence 1: NP_524214.1
• Gene: Hem / 40462
• FlyBaseID: FBgn0011771
• Length: 1126
• Species: Drosophila melanogaster
• Sequence 2: XP_038961669.1
• Gene: Nckap1 / 58823
• RGDID: 61939
• Length: 1134
• Species: Rattus norvegicus
• Alignment Length: 1135
• Identity: 676/1135 - (59%)
• Similarity: 866/1135 - (76%)
• Gaps: 24/1135 - (2%)

  Fly     1 MARPIF-PNQQKIAEKLIILNDRGLGILTRIYNIK------KACGDTKSKPGFLSEKSLESSIKF 58
            |:|.:. |:|||:||||.||||||:|:|||:||||      |||||.|:||.:|.:|:|||::||
  Rat     1 MSRSVLQPSQQKLAEKLTILNDRGVGMLTRLYNIKKQGQVWKACGDPKAKPSYLIDKNLESAVKF 65

  Fly    59 IVKRFPNIDVKGLN----AIVNIKAEIIKSLSLYYHTFVDLLDFKDNVCELLTTMDACQIHLDIT 119
            ||::||.::.:..|    .:...|:||:|:|:|||.||||:::|||:||:||.|:|.||:..|||
  Rat    66 IVRKFPAVETRNNNQQLAQLQKEKSEILKNLALYYFTFVDVMEFKDHVCDLLNTIDVCQVFFDIT 130

  Fly   120 LNFELTKYYLDLVVTYVSLMIVLSRVEDRKAVLGLYNAAYELQNNQADTGFPRLGQMILDYEVPL 184
            :||:|||.||||.|||.:|||:|||:|:|||::||||.|:|:.:..:|..:|||||||:|||.||
  Rat   131 VNFDLTKNYLDLTVTYTTLMILLSRIEERKAIIGLYNYAHEMTHGASDREYPRLGQMIVDYEHPL 195

  Fly   185 KKLAEEFIPHQRLLTSALRSLTSIYALRNLPADKWREMQKLSLVGNPAILLKAVRTDTMSCEYIS 249
            ||:.|||:||.:.|:.||.||..:|..|||.||:||..|.|||:..|:.:|...::|||.|||:|
  Rat   196 KKMMEEFVPHSKSLSDALISLQMVYPRRNLSADQWRNAQLLSLISAPSTMLNPAQSDTMPCEYLS 260

  Fly   250 LEAMDRWIIFGLLLNHQMLGQYPEVNKIWLSALESSWVVALFRDEVLQIHQYIQATFDGIKGYSK 314
            |:||::|||||.:|.|.||........:|..||:||..::||||||..||:..:..|..|:||:|
  Rat   261 LDAMEKWIIFGFILCHGMLNTEATALNLWKLALQSSSCLSLFRDEVFHIHKAAEDLFVNIRGYNK 325

  Fly   315 RIGEVKEAYNTAVQKAALMHRERRKFLRTALKELALIMTDQPGLLGPKAIFIFIGLCLARDEILW 379
            ||.:::|....||..|..||||||||||:||||||.:::||||||||||:|:|:.|..|||||:|
  Rat   326 RINDIRECKEAAVSHAGSMHRERRKFLRSALKELATVLSDQPGLLGPKALFVFMALSFARDEIIW 390

  Fly   380 LLRHNDNPPLLKNKGKSNEDLVDRQLPELLFHMEELRALVRKYSQVMQRYYVQYLSGFDATDLNI 444
            ||||.||.|     .||.:|.:|:.:.||:|:||||||.||||..|||||||||||||||..||.
  Rat   391 LLRHADNMP-----KKSADDFIDKHIAELIFYMEELRAHVRKYGPVMQRYYVQYLSGFDAVVLNE 450

  Fly   445 RMQSLQMCPEDESIIFSSLYNTAAALTVKQVEDNELFYFRPFRLDWFRLQTYMSVGKAALRIAEH 509
            .:|:|.:||||||||.||..||..:|:||||||.|:|.||..||||||||.|.||.||:|.:|:|
  Rat   451 LVQNLSVCPEDESIIMSSFVNTMTSLSVKQVEDGEVFDFRGMRLDWFRLQAYTSVSKASLSLADH 515

  Fly   510 AELARLLDSMVFHTRVVDNLDEILVETSDLSIFCFYNKMFDDQFHMCLEFPAQNRYIIAFPLICS 574
            .||.:::::::|||::||:|.|:|||||||||||||::.|:..|..|||.|:|:||.|||||:|:
  Rat   516 RELGKMMNTIIFHTKMVDSLVEMLVETSDLSIFCFYSRAFEKMFQQCLELPSQSRYSIAFPLLCT 580

  Fly   575 HFQNCTHEMCPEERHHIRERSLSVVNIFLEEMAKEAKNIITTICDEQCTMADALLPKHCAKILSV 639
            ||.:||||:||||||||.:||||:.|:||:||||:|:|:||.||.||||::|.||||||||.:|
  Rat   581 HFMSCTHELCPEERHHIGDRSLSLCNMFLDEMAKQARNLITDICTEQCTLSDQLLPKHCAKTIS- 644

  Fly   640 QSARKKKDKSKSKHFDDIR-KPGDESYRKTREDLTTMDKLHMALTELCFAINYCPTVNVWEFAFA 703
            |:..||..|...|..:..| |||.||.||.|..:|.:||||.||:||||:|||.|.:.|||..|.
  Rat   645 QAVNKKSKKQTGKKGEPEREKPGVESMRKNRLVVTNLDKLHTALSELCFSINYVPNMAVWEHTFT 709

  Fly   704 PREYLCQNLEHRFSRDLVGMVMFNQETMEIAKPSELLASVRAYMNVLQTVENYVHIDITRVFNNC 768
            |||||..:||.||::.:|||.|:||.|.|||||||||.||||||.|||::||||.|||||||||.
  Rat   710 PREYLTSHLEIRFTKSIVGMTMYNQATQEIAKPSELLTSVRAYMTVLQSIENYVQIDITRVFNNV 774

  Fly   769 LLQQTQALDSHGEKTIAALYNTWYSEVLLRRVSAGNIVFSINQKAFVPISPEGWVPFNPQEFSDL 833
            ||||||.||||||.||.:||..||.|.|||:||.|:|.:....||||.:..|..:.||.:|:||:
  Rat   775 LLQQTQHLDSHGEPTITSLYTNWYLETLLRQVSNGHIAYFPAMKAFVNLPTENELTFNAEEYSDI 839

  Fly   834 NELRALAELVGPYGIKTLNETLMWHIANQVQELKSLVSTNKEVLITLRTSFDKPEVMKEQFKRLQ 898
            :|:|:|:||:||||:|.|:|:|||||::||.|||.||..|.:||..:|||||||:.|...||||.
  Rat   840 SEMRSLSELLGPYGMKFLSESLMWHISSQVAELKKLVVENVDVLTQMRTSFDKPDQMAALFKRLS 904

  Fly   899 DVDRVLQRMTIIGVIICFRNLVHEALVDVLDKRIPFLLSSVKDFQEHLPGGDQIRVAS---EMAS 960
            .||.||:||||||||:.||:|..|||.|||...||||:||::||::|:|....::||.   |::|
  Rat   905 SVDSVLKRMTIIGVILSFRSLAQEALRDVLSYHIPFLVSSIEDFKDHIPRETDMKVAMNVYELSS 969

  Fly   961 AAGLLCKVDPTLATTLKSKKPE--FDEGEHLTACLLMVFVAVSIPKLARNENSFYRATIDGHSNN 1023
            ||||.|::||.|...|.|:|.|  ..|.|:..|||||||||||:|.||.|..|.|...|:||.||
  Rat   970 AAGLPCEIDPALVVALSSQKSENISPEEEYKIACLLMVFVAVSLPTLASNVMSQYSPAIEGHCNN 1034

  Fly  1024 THCMAAAINNIFGALFTICGQSDMEDRMKEFLALASSSLLRLGQESDKEATRNRESIYLLLDEIV 1088
            .||:|.|||.|..||||| .:..:|||:||||||||||||::|||:||..||||||:|||||.||
  Rat  1035 IHCLAKAINQIAAALFTI-HKGSIEDRLKEFLALASSSLLKIGQETDKTTTRNRESVYLLLDMIV 1098

  Fly  1089 KQSPFLTMDLLESCFPYVLIRNAYHGVYKQ 1118
            ::|||||||||||||||||:|||||.||||
  Rat  1099 QESPFLTMDLLESCFPYVLLRNAYHAVYKQ 1128

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hem	NP_524214.1	Nckap1	12..1118	CDD:462866	668/1121 (60%)
Nckap1	XP_038961669.1	Nckap1	13..1128	CDD:462866	668/1121 (60%)