Protein Alignment Hem and Nckap1l

DIOPT Version :10

• Sequence 1: NP_524214.1
• Gene: Hem / 40462
• FlyBaseID: FBgn0011771
• Length: 1126
• Species: Drosophila melanogaster
• Sequence 2: NP_001401880.1
• Gene: Nckap1l / 315348
• RGDID: 1312032
• Length: 1134
• Species: Rattus norvegicus
• Alignment Length: 1118
• Identity: 536/1118 - (47%)
• Similarity: 768/1118 - (68%)
• Gaps: 16/1118 - (1%)

  Fly     9 QQKIAEKLIILNDRGLGILTRIYNIKKACGDTKSKPGFLSEKSLESSIKFIVKRFPNIDVKG--- 70
            |.|:||||.||||||.|:|.|:|||||.|.|.||||.||.|||:||.:|:|.|:||||||:.
  Rat     8 QHKLAEKLTILNDRGQGVLIRMYNIKKTCSDPKSKPPFLLEKSMESCLKYINKKFPNIDVRNSTQ 72

  Fly    71 -LNAIVNIKAEIIKSLSLYYHTFVDLLDFKDNVCELLTTMDACQIHLDITLNFELTKYYLDLVVT 134
             |..:...|||||:.|:.||.:|||:::|:|:|.|||.|:||||.|.||.|||:.|:.||||:||
  Rat    73 HLGPVHREKAEIIRFLTNYYQSFVDVMEFRDHVYELLNTIDACQCHFDINLNFDFTRSYLDLIVT 137

  Fly   135 YVSLMIVLSRVEDRKAVLGLYNAAYELQNNQADTGFPRLGQMILDYEVPLKKLAEEFIPHQRLLT 199
            |.|::::|||:|||:.::|:||.|:|:.:...|..|||||||:|:|:.|||||.|||.||.:.::
  Rat   138 YTSVILLLSRIEDRRLLIGMYNCAHEMLHGHGDPSFPRLGQMVLEYDHPLKKLTEEFGPHTKAVS 202

  Fly   200 SALRSLTSIYALRNLPADKWREMQKLSLVGNPAILLKAVRTDTMSCEYISLEAMDRWIIFGLLLN 264
            .||.||..::..||..|::||..|.|||:.:|..::....:|||:|||:|:|.|:||||.|.||.
  Rat   203 GALLSLYFLFVRRNQGAEQWRSAQLLSLISSPPAMINPANSDTMACEYLSVEVMERWIIIGFLLC 267

  Fly   265 HQMLGQYPEVNKIWLSALESSWVVALFRDEVLQIHQYIQATFDGIKGYSKRIGEVKEAYNTAVQK 329
            |..|....:..|:|...||.|..:.|.|::|||:|:..:..|..:||||||:.::||:...|:..
  Rat   268 HGCLNSNSQCQKLWKLCLEGSLYITLIREDVLQVHKVTEDLFSSLKGYSKRVADIKESKEHAITN 332

  Fly   330 AALMHRERRKFLRTALKELALIMTDQPGLLGPKAIFIFIGLCLARDEILWLLRHNDNPPLLKNKG 394
            :...|.:||:|||||:|||..::.|:||||||||:|.|:.|...|||:.||:||.:|    ..|.
  Rat   333 SGQFHCQRRQFLRTAVKELETVLNDEPGLLGPKALFAFMALSFIRDEVTWLVRHTEN----VTKT 393

  Fly   395 KSNEDLVDRQLPELLFHMEELRALVRKYSQVMQRYYVQYLSGFDATDLNIRMQSLQMCPEDESII 459
            |:.||..|..:.||||.:||:|||||::.:|:|:|::|||:.||...|:..:|:|.:|||:||:|
  Rat   394 KTPEDYADSSIAELLFLLEEIRALVRRHIKVIQQYHLQYLARFDVLVLSDIIQNLTVCPEEESVI 458

  Fly   460 FSSLYNTAAALTVKQVEDNELFYFRPFRLDWFRLQTYMSVGKAALRIAEHAELARLLDSMVFHTR 524
            .||..:|.::|.:|||::.|.|.|...||||||||.|.||.||.|.:.|:.:||::::.::||::
  Rat   459 MSSFVSTLSSLNLKQVDNEEKFDFSGLRLDWFRLQAYTSVAKAPLHLHENPDLAKVMNLIIFHSQ 523

  Fly   525 VVDNLDEILVETSDLSIFCFYNKMFDDQFHMCLEFPAQNRYIIAFPLICSHFQNCTHEMCPEERH 589
            ::|:::::||||||||.|||:.:.|:..|...||.|...||.|||||||:||.:|.|||||||..
  Rat   524 MLDSVEKMLVETSDLSTFCFHLRTFEKMFATTLEEPTMLRYTIAFPLICAHFVHCIHEMCPEEYP 588

  Fly   590 HIRERSLSVVNIFLEEMAKEAKNIITTICDEQCTMADALLPKHCAKILSVQSARK--KKDKSKSK 652
            |::...|...|.||||:||:..|.:..||.||..:.:.|||||||..:|....||  |:.::..|
  Rat   589 HLKNHGLHHCNSFLEELAKQTSNCVLEICAEQRNLNEQLLPKHCATTISKAKNRKSMKQRQAPRK 653

  Fly   653 HFDDIRKPGDESYRKTREDLTTMDKLHMALTELCFAINYCPTVNVWEFAFAPREYLCQNLEHRFS 717
            ...:..|||.||:||.|..:|.|||||:.||||..|:|:..:.:|:|....|.|||..:||.|.:
  Rat   654 GEPERDKPGAESHRKNRSLVTNMDKLHLNLTELALAMNHVHSFSVFEHTIFPSEYLSSHLESRLN 718

  Fly   718 RDLVGMVMFNQETMEIAKPSELLASVRAYMNVLQTVENYVHIDITRVFNNCLLQQTQALDSHGEK 782
            |.:|.:..:|..|.||.:||||||.|:||.:.:|::..::..|.:|:..|.||||||.|||.||:
  Rat   719 RAIVSLAGYNATTQEILRPSELLAGVKAYTSFIQSLAQFLGTDASRIVRNALLQQTQPLDSCGEQ 783

  Fly   783 TIAALYNTWYSEVLLRRVSAGNIVFSINQKAFVPISPEGWVPFNPQEFSDLNELRALAELVGPYG 847
            |:..||..||.|.|||:.|:|.||.|...:||:.:..:|...|:.:||||::|:|||||::||||
  Rat   784 TVTTLYTNWYLESLLRQASSGTIVLSPAMQAFISLPRDGEQNFSAEEFSDISEMRALAEILGPYG 848

  Fly   848 IKTLNETLMWHIANQVQELKSLVSTNKEVLITLRTSFDKPEVMKEQFKRLQDVDRVLQRMTIIGV 912
            :|.|:|.||||:.:|:.|||.||..|.::|:.:|::|.|||:|.....:|...:.||:|||||||
  Rat   849 MKFLSENLMWHVTSQIVELKKLVVENMDILVQIRSNFTKPELMASLLPQLTGAENVLKRMTIIGV 913

  Fly   913 IICFRNLVHEALVDVLDKRIPFLLSSVKDFQEHLPGGDQIRV---ASEMASAAGLLCKVDPTLAT 974
            |:.||.:..|.|.:|.....|||:..::..:|.:.....|:|   ..|:|.|||:.|.:||.|..
  Rat   914 ILSFRAMAQEGLQEVFSAHCPFLMGPIECLKEFVTPDTDIKVTLSVFELACAAGVSCDIDPALVA 978

  Fly   975 TLKSKKPE--FDEGEHLTACLLMVFVAVSIPKLARNENSFYRATIDGHSNNTHCMAAAINNIFGA 1037
            .:.:.|.:  ..|.|:..||||::|:|||:|.||.:.:||:....||::||.||:..||..:..|
  Rat   979 AIANLKADNSSPEEEYKVACLLLIFLAVSLPLLATDPSSFFSIEKDGYNNNIHCLTKAIIQVSAA 1043

  Fly  1038 LFTICGQSDMEDRMKEFLALASSSLLRLGQESDKEATRNRESIYLLLDEIVKQSPFLTMDLLESC 1102
            |||:..: ::|..:||||.:||.|||:||||:||..|||||||.||:..:|::|||||:|:||||
  Rat  1044 LFTLYNK-NIETHLKEFLVVASVSLLQLGQETDKLKTRNRESISLLMRLVVEESPFLTLDMLESC 1107

  Fly  1103 FPYVLIRNAYHGV 1115
            |||||:||||..|
  Rat  1108 FPYVLLRNAYREV 1120

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hem	NP_524214.1	Nckap1	12..1118	CDD:462866	534/1115 (48%)
Nckap1l	NP_001401880.1	Nckap1	11..1123	CDD:462866	534/1115 (48%)