DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hem and NCKAP1L

DIOPT Version :9

Sequence 1:	NP_524214.1	Gene:	Hem / 40462	FlyBaseID:	FBgn0011771	Length:	1126	Species:	Drosophila melanogaster
Sequence 2:	NP_005328.2	Gene:	NCKAP1L / 3071	HGNCID:	4862	Length:	1127	Species:	Homo sapiens

Alignment Length:	1118	Identity:	537/1118 - (48%)
Similarity:	766/1118 - (68%)	Gaps:	16/1118 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 QQKIAEKLIILNDRGLGILTRIYNIKKACGDTKSKPGFLSEKSLESSIKFIVKRFPNIDVKG--- 70
            |.|:||||.||||||.|:|.|:|||||.|.|.||||.||.|||:|.|:|:|.|:||||||:.
Human     8 QHKLAEKLTILNDRGQGVLIRMYNIKKTCSDPKSKPPFLLEKSMEPSLKYINKKFPNIDVRNSTQ 72

  Fly    71 -LNAIVNIKAEIIKSLSLYYHTFVDLLDFKDNVCELLTTMDACQIHLDITLNFELTKYYLDLVVT 134
             |..:...|||||:.|:.||.:|||:::|:|:|.|||.|:||||.|.||.|||:.|:.||||:||
Human    73 HLGPVHREKAEIIRFLTNYYQSFVDVMEFRDHVYELLNTIDACQCHFDINLNFDFTRSYLDLIVT 137

  Fly   135 YVSLMIVLSRVEDRKAVLGLYNAAYELQNNQADTGFPRLGQMILDYEVPLKKLAEEFIPHQRLLT 199
            |.|::::|||:|||:.::|:||.|:|:.:...|..|.|||||:|:|:.|||||.|||.||.:.::
Human   138 YTSVILLLSRIEDRRILIGMYNCAHEMLHGHGDPSFARLGQMVLEYDHPLKKLTEEFGPHTKAVS 202

  Fly   200 SALRSLTSIYALRNLPADKWREMQKLSLVGNPAILLKAVRTDTMSCEYISLEAMDRWIIFGLLLN 264
            .||.||..::..||..|::||..|.|||:.||..::....:|||:|||:|:|.|:||||.|.||.
Human   203 GALLSLHFLFVRRNQGAEQWRSAQLLSLISNPPAMINPANSDTMACEYLSVEVMERWIIIGFLLC 267

  Fly   265 HQMLGQYPEVNKIWLSALESSWVVALFRDEVLQIHQYIQATFDGIKGYSKRIGEVKEAYNTAVQK 329
            |..|....:..|:|...|:.|..:.|.|::|||:|:..:..|..:|||.||:.::||:....:..
Human   268 HGCLNSNSQCQKLWKLCLQGSLYITLIREDVLQVHKVTEDLFSSLKGYGKRVADIKESKEHVIAN 332

  Fly   330 AALMHRERRKFLRTALKELALIMTDQPGLLGPKAIFIFIGLCLARDEILWLLRHNDNPPLLKNKG 394
            :...|.:||:|||.|:|||..::.|:||||||||:|.|:.|...|||:.||:||.:|    ..|.
Human   333 SGQFHCQRRQFLRMAVKELETVLADEPGLLGPKALFAFMALSFIRDEVTWLVRHTEN----VTKT 393

  Fly   395 KSNEDLVDRQLPELLFHMEELRALVRKYSQVMQRYYVQYLSGFDATDLNIRMQSLQMCPEDESII 459
            |:.||..|..:.||||.:|.:|:|||::.:|:|:|::|||:.|||..|:..:|:|.:|||:||||
Human   394 KTPEDYADSSIAELLFLLEGIRSLVRRHIKVIQQYHLQYLARFDALVLSDIIQNLSVCPEEESII 458

  Fly   460 FSSLYNTAAALTVKQVEDNELFYFRPFRLDWFRLQTYMSVGKAALRIAEHAELARLLDSMVFHTR 524
            .||..:..::|.:|||::.|.|.|...||||||||.|.||.||.|.:.|:.:||::::.:|||:|
Human   459 MSSFVSILSSLNLKQVDNGEKFEFSGLRLDWFRLQAYTSVAKAPLHLHENPDLAKVMNLIVFHSR 523

  Fly   525 VVDNLDEILVETSDLSIFCFYNKMFDDQFHMCLEFPAQNRYIIAFPLICSHFQNCTHEMCPEERH 589
            ::|:::::||||||||.|||:.::|:..|.|.||..|..||.|||||||:||.:|||||||||..
Human   524 MLDSVEKLLVETSDLSTFCFHLRIFEKMFAMTLEESAMLRYAIAFPLICAHFVHCTHEMCPEEYP 588

  Fly   590 HIRERSLSVVNIFLEEMAKEAKNIITTICDEQCTMADALLPKHCAKILSVQSARK--KKDKSKSK 652
            |::...|...|.||||:||:..|.:..||.||..:::.|||||||..:|....:|  |:.::..|
Human   589 HLKNHGLHHCNSFLEELAKQTSNCVLEICAEQRNLSEQLLPKHCATTISKAKNKKTRKQRQTPRK 653

  Fly   653 HFDDIRKPGDESYRKTREDLTTMDKLHMALTELCFAINYCPTVNVWEFAFAPREYLCQNLEHRFS 717
            ...:..|||.||:||.|..:|.|||||:.||||...:|:..:.:|:|....|.|||..:||.|.:
Human   654 GEPERDKPGAESHRKNRSIVTNMDKLHLNLTELALTMNHVYSFSVFEHTIFPSEYLSSHLEARLN 718

  Fly   718 RDLVGMVMFNQETMEIAKPSELLASVRAYMNVLQTVENYVHIDITRVFNNCLLQQTQALDSHGEK 782
            |.:|.:..:|..|.||.:||||||.|:||:..:|::..::..|.:||..|.||||||.|||.||:
Human   719 RAIVWLAGYNATTQEIVRPSELLAGVKAYIGFIQSLAQFLGADASRVIRNALLQQTQPLDSCGEQ 783

  Fly   783 TIAALYNTWYSEVLLRRVSAGNIVFSINQKAFVPISPEGWVPFNPQEFSDLNELRALAELVGPYG 847
            ||..||..||.|.|||:.|:|.|:.|...:|||.:..||...|:.:||||::|:||||||:||||
Human   784 TITTLYTNWYLESLLRQASSGTIILSPAMQAFVSLPREGEQNFSAEEFSDISEMRALAELLGPYG 848

  Fly   848 IKTLNETLMWHIANQVQELKSLVSTNKEVLITLRTSFDKPEVMKEQFKRLQDVDRVLQRMTIIGV 912
            :|.|:|.||||:.:|:.|||.||..|.::|:.:|::|.||::|.....:|...:.||:|||||||
Human   849 MKFLSENLMWHVTSQIVELKKLVVENMDILVQIRSNFSKPDLMASLLPQLTGAENVLKRMTIIGV 913

  Fly   913 IICFRNLVHEALVDVLDKRIPFLLSSVKDFQEHLPGGDQIRVA---SEMASAAGLLCKVDPTLAT 974
            |:.||.:..|.|.:|.....|||:..::..:|.:.....|:|.   .|:|||||:.|.:||.|..
Human   914 ILSFRAMAQEGLREVFSSHCPFLMGPIECLKEFVTPDTDIKVTLSIFELASAAGVGCDIDPALVA 978

  Fly   975 TLKSKKPEFD--EGEHLTACLLMVFVAVSIPKLARNENSFYRATIDGHSNNTHCMAAAINNIFGA 1037
            .:.:.|.:..  |.|:..||||::|:|||:|.||.:.:|||....||::||.||:..||..:..|
Human   979 AIANLKADTSSPEEEYKVACLLLIFLAVSLPLLATDPSSFYSIEKDGYNNNIHCLTKAIIQVSAA 1043

  Fly  1038 LFTICGQSDMEDRMKEFLALASSSLLRLGQESDKEATRNRESIYLLLDEIVKQSPFLTMDLLESC 1102
            |||:..: ::|..:||||.:||.|||:||||:||..|||||||.||:..:|::|.|||:|:||||
Human  1044 LFTLYNK-NIETHLKEFLVVASVSLLQLGQETDKLKTRNRESISLLMRLVVEESSFLTLDMLESC 1107

  Fly  1103 FPYVLIRNAYHGV 1115
            |||||:||||..|
Human  1108 FPYVLLRNAYREV 1120

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hem	NP_524214.1	Nckap1	12..1118	CDD:286778	535/1115 (48%)
NCKAP1L	NP_005328.2	Nckap1	11..1123	CDD:286778	535/1115 (48%)
NCKAP1L	NP_005328.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	638..670		10/31 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1917
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54606
OrthoDB	1	1.010	-	-		D138196at2759
OrthoFinder	1	1.000	-	-		FOG0003146
OrthoInspector	1	1.000	-	-		otm41515
orthoMCL	1	0.900	-	-		OOG6_103432
Panther	1	1.100	-	-	O	PTHR12093
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2542
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.790