Protein Alignment Hem and NCKAP1L

DIOPT Version :10

• Sequence 1: NP_524214.1
• Gene: Hem / 40462
• FlyBaseID: FBgn0011771
• Length: 1126
• Species: Drosophila melanogaster
• Sequence 2: NP_005328.2
• Gene: NCKAP1L / 3071
• HGNCID: 4862
• Length: 1127
• Species: Homo sapiens
• Alignment Length: 1118
• Identity: 537/1118 - (48%)
• Similarity: 766/1118 - (68%)
• Gaps: 16/1118 - (1%)

  Fly     9 QQKIAEKLIILNDRGLGILTRIYNIKKACGDTKSKPGFLSEKSLESSIKFIVKRFPNIDVKG--- 70
            |.|:||||.||||||.|:|.|:|||||.|.|.||||.||.|||:|.|:|:|.|:||||||:.
Human     8 QHKLAEKLTILNDRGQGVLIRMYNIKKTCSDPKSKPPFLLEKSMEPSLKYINKKFPNIDVRNSTQ 72

  Fly    71 -LNAIVNIKAEIIKSLSLYYHTFVDLLDFKDNVCELLTTMDACQIHLDITLNFELTKYYLDLVVT 134
             |..:...|||||:.|:.||.:|||:::|:|:|.|||.|:||||.|.||.|||:.|:.||||:||
Human    73 HLGPVHREKAEIIRFLTNYYQSFVDVMEFRDHVYELLNTIDACQCHFDINLNFDFTRSYLDLIVT 137

  Fly   135 YVSLMIVLSRVEDRKAVLGLYNAAYELQNNQADTGFPRLGQMILDYEVPLKKLAEEFIPHQRLLT 199
            |.|::::|||:|||:.::|:||.|:|:.:...|..|.|||||:|:|:.|||||.|||.||.:.::
Human   138 YTSVILLLSRIEDRRILIGMYNCAHEMLHGHGDPSFARLGQMVLEYDHPLKKLTEEFGPHTKAVS 202

  Fly   200 SALRSLTSIYALRNLPADKWREMQKLSLVGNPAILLKAVRTDTMSCEYISLEAMDRWIIFGLLLN 264
            .||.||..::..||..|::||..|.|||:.||..::....:|||:|||:|:|.|:||||.|.||.
Human   203 GALLSLHFLFVRRNQGAEQWRSAQLLSLISNPPAMINPANSDTMACEYLSVEVMERWIIIGFLLC 267

  Fly   265 HQMLGQYPEVNKIWLSALESSWVVALFRDEVLQIHQYIQATFDGIKGYSKRIGEVKEAYNTAVQK 329
            |..|....:..|:|...|:.|..:.|.|::|||:|:..:..|..:|||.||:.::||:....:..
Human   268 HGCLNSNSQCQKLWKLCLQGSLYITLIREDVLQVHKVTEDLFSSLKGYGKRVADIKESKEHVIAN 332

  Fly   330 AALMHRERRKFLRTALKELALIMTDQPGLLGPKAIFIFIGLCLARDEILWLLRHNDNPPLLKNKG 394
            :...|.:||:|||.|:|||..::.|:||||||||:|.|:.|...|||:.||:||.:|    ..|.
Human   333 SGQFHCQRRQFLRMAVKELETVLADEPGLLGPKALFAFMALSFIRDEVTWLVRHTEN----VTKT 393

  Fly   395 KSNEDLVDRQLPELLFHMEELRALVRKYSQVMQRYYVQYLSGFDATDLNIRMQSLQMCPEDESII 459
            |:.||..|..:.||||.:|.:|:|||::.:|:|:|::|||:.|||..|:..:|:|.:|||:||||
Human   394 KTPEDYADSSIAELLFLLEGIRSLVRRHIKVIQQYHLQYLARFDALVLSDIIQNLSVCPEEESII 458

  Fly   460 FSSLYNTAAALTVKQVEDNELFYFRPFRLDWFRLQTYMSVGKAALRIAEHAELARLLDSMVFHTR 524
            .||..:..::|.:|||::.|.|.|...||||||||.|.||.||.|.:.|:.:||::::.:|||:|
Human   459 MSSFVSILSSLNLKQVDNGEKFEFSGLRLDWFRLQAYTSVAKAPLHLHENPDLAKVMNLIVFHSR 523

  Fly   525 VVDNLDEILVETSDLSIFCFYNKMFDDQFHMCLEFPAQNRYIIAFPLICSHFQNCTHEMCPEERH 589
            ::|:::::||||||||.|||:.::|:..|.|.||..|..||.|||||||:||.:|||||||||..
Human   524 MLDSVEKLLVETSDLSTFCFHLRIFEKMFAMTLEESAMLRYAIAFPLICAHFVHCTHEMCPEEYP 588

  Fly   590 HIRERSLSVVNIFLEEMAKEAKNIITTICDEQCTMADALLPKHCAKILSVQSARK--KKDKSKSK 652
            |::...|...|.||||:||:..|.:..||.||..:::.|||||||..:|....:|  |:.::..|
Human   589 HLKNHGLHHCNSFLEELAKQTSNCVLEICAEQRNLSEQLLPKHCATTISKAKNKKTRKQRQTPRK 653

  Fly   653 HFDDIRKPGDESYRKTREDLTTMDKLHMALTELCFAINYCPTVNVWEFAFAPREYLCQNLEHRFS 717
            ...:..|||.||:||.|..:|.|||||:.||||...:|:..:.:|:|....|.|||..:||.|.:
Human   654 GEPERDKPGAESHRKNRSIVTNMDKLHLNLTELALTMNHVYSFSVFEHTIFPSEYLSSHLEARLN 718

  Fly   718 RDLVGMVMFNQETMEIAKPSELLASVRAYMNVLQTVENYVHIDITRVFNNCLLQQTQALDSHGEK 782
            |.:|.:..:|..|.||.:||||||.|:||:..:|::..::..|.:||..|.||||||.|||.||:
Human   719 RAIVWLAGYNATTQEIVRPSELLAGVKAYIGFIQSLAQFLGADASRVIRNALLQQTQPLDSCGEQ 783

  Fly   783 TIAALYNTWYSEVLLRRVSAGNIVFSINQKAFVPISPEGWVPFNPQEFSDLNELRALAELVGPYG 847
            ||..||..||.|.|||:.|:|.|:.|...:|||.:..||...|:.:||||::|:||||||:||||
Human   784 TITTLYTNWYLESLLRQASSGTIILSPAMQAFVSLPREGEQNFSAEEFSDISEMRALAELLGPYG 848

  Fly   848 IKTLNETLMWHIANQVQELKSLVSTNKEVLITLRTSFDKPEVMKEQFKRLQDVDRVLQRMTIIGV 912
            :|.|:|.||||:.:|:.|||.||..|.::|:.:|::|.||::|.....:|...:.||:|||||||
Human   849 MKFLSENLMWHVTSQIVELKKLVVENMDILVQIRSNFSKPDLMASLLPQLTGAENVLKRMTIIGV 913

  Fly   913 IICFRNLVHEALVDVLDKRIPFLLSSVKDFQEHLPGGDQIRVA---SEMASAAGLLCKVDPTLAT 974
            |:.||.:..|.|.:|.....|||:..::..:|.:.....|:|.   .|:|||||:.|.:||.|..
Human   914 ILSFRAMAQEGLREVFSSHCPFLMGPIECLKEFVTPDTDIKVTLSIFELASAAGVGCDIDPALVA 978

  Fly   975 TLKSKKPEFD--EGEHLTACLLMVFVAVSIPKLARNENSFYRATIDGHSNNTHCMAAAINNIFGA 1037
            .:.:.|.:..  |.|:..||||::|:|||:|.||.:.:|||....||::||.||:..||..:..|
Human   979 AIANLKADTSSPEEEYKVACLLLIFLAVSLPLLATDPSSFYSIEKDGYNNNIHCLTKAIIQVSAA 1043

  Fly  1038 LFTICGQSDMEDRMKEFLALASSSLLRLGQESDKEATRNRESIYLLLDEIVKQSPFLTMDLLESC 1102
            |||:..: ::|..:||||.:||.|||:||||:||..|||||||.||:..:|::|.|||:|:||||
Human  1044 LFTLYNK-NIETHLKEFLVVASVSLLQLGQETDKLKTRNRESISLLMRLVVEESSFLTLDMLESC 1107

  Fly  1103 FPYVLIRNAYHGV 1115
            |||||:||||..|
Human  1108 FPYVLLRNAYREV 1120

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hem	NP_524214.1	Nckap1	12..1118	CDD:462866	535/1115 (48%)
NCKAP1L	NP_005328.2	Nckap1	11..1123	CDD:462866	535/1115 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	638..670		10/31 (32%)