Protein Alignment Hem and NCKAP1

DIOPT Version :10

• Sequence 1: NP_524214.1
• Gene: Hem / 40462
• FlyBaseID: FBgn0011771
• Length: 1126
• Species: Drosophila melanogaster
• Sequence 2: NP_995314.1
• Gene: NCKAP1 / 10787
• HGNCID: 7666
• Length: 1134
• Species: Homo sapiens
• Alignment Length: 1135
• Identity: 675/1135 - (59%)
• Similarity: 867/1135 - (76%)
• Gaps: 24/1135 - (2%)

  Fly     1 MARPIF-PNQQKIAEKLIILNDRGLGILTRIYNIK------KACGDTKSKPGFLSEKSLESSIKF 58
            |:|.:. |:|||:||||.||||||:|:|||:||||      |||||.|:||.:|.:|:|||::||
Human     1 MSRSVLQPSQQKLAEKLTILNDRGVGMLTRLYNIKKQGQVWKACGDPKAKPSYLIDKNLESAVKF 65

  Fly    59 IVKRFPNIDVKGLN----AIVNIKAEIIKSLSLYYHTFVDLLDFKDNVCELLTTMDACQIHLDIT 119
            ||::||.::.:..|    .:...|:||:|:|:|||.||||:::|||:|||||.|:|.||:..|||
Human    66 IVRKFPAVETRNNNQQLAQLQKEKSEILKNLALYYFTFVDVMEFKDHVCELLNTIDVCQVFFDIT 130

  Fly   120 LNFELTKYYLDLVVTYVSLMIVLSRVEDRKAVLGLYNAAYELQNNQADTGFPRLGQMILDYEVPL 184
            :||:|||.||||::||.:|||:|||:|:|||::||||.|:|:.:..:|..:|||||||:|||.||
Human   131 VNFDLTKNYLDLIITYTTLMILLSRIEERKAIIGLYNYAHEMTHGASDREYPRLGQMIVDYENPL 195

  Fly   185 KKLAEEFIPHQRLLTSALRSLTSIYALRNLPADKWREMQKLSLVGNPAILLKAVRTDTMSCEYIS 249
            ||:.|||:||.:.|:.||.||..:|..|||.||:||..|.|||:..|:.:|...::|||.|||:|
Human   196 KKMMEEFVPHSKSLSDALISLQMVYPRRNLSADQWRNAQLLSLISAPSTMLNPAQSDTMPCEYLS 260

  Fly   250 LEAMDRWIIFGLLLNHQMLGQYPEVNKIWLSALESSWVVALFRDEVLQIHQYIQATFDGIKGYSK 314
            |:||::|||||.:|.|.:|........:|..||:||..::||||||..||:..:..|..|:||:|
Human   261 LDAMEKWIIFGFILCHGILNTDATALNLWKLALQSSSCLSLFRDEVFHIHKAAEDLFVNIRGYNK 325

  Fly   315 RIGEVKEAYNTAVQKAALMHRERRKFLRTALKELALIMTDQPGLLGPKAIFIFIGLCLARDEILW 379
            ||.:::|....||..|..||||||||||:||||||.:::||||||||||:|:|:.|..|||||:|
Human   326 RINDIRECKEAAVSHAGSMHRERRKFLRSALKELATVLSDQPGLLGPKALFVFMALSFARDEIIW 390

  Fly   380 LLRHNDNPPLLKNKGKSNEDLVDRQLPELLFHMEELRALVRKYSQVMQRYYVQYLSGFDATDLNI 444
            ||||.||.|     .||.:|.:|:.:.||:|:||||||.||||..|||||||||||||||..||.
Human   391 LLRHADNMP-----KKSADDFIDKHIAELIFYMEELRAHVRKYGPVMQRYYVQYLSGFDAVVLNE 450

  Fly   445 RMQSLQMCPEDESIIFSSLYNTAAALTVKQVEDNELFYFRPFRLDWFRLQTYMSVGKAALRIAEH 509
            .:|:|.:||||||||.||..||..:|:||||||.|:|.||..||||||||.|.||.||:|.:|:|
Human   451 LVQNLSVCPEDESIIMSSFVNTMTSLSVKQVEDGEVFDFRGMRLDWFRLQAYTSVSKASLGLADH 515

  Fly   510 AELARLLDSMVFHTRVVDNLDEILVETSDLSIFCFYNKMFDDQFHMCLEFPAQNRYIIAFPLICS 574
            .||.:::::::|||::||:|.|:|||||||||||||::.|:..|..|||.|:|:||.|||||:|:
Human   516 RELGKMMNTIIFHTKMVDSLVEMLVETSDLSIFCFYSRAFEKMFQQCLELPSQSRYSIAFPLLCT 580

  Fly   575 HFQNCTHEMCPEERHHIRERSLSVVNIFLEEMAKEAKNIITTICDEQCTMADALLPKHCAKILSV 639
            ||.:||||:||||||||.:||||:.|:||:||||:|:|:||.||.||||::|.||||||||.:|
Human   581 HFMSCTHELCPEERHHIGDRSLSLCNMFLDEMAKQARNLITDICTEQCTLSDQLLPKHCAKTIS- 644

  Fly   640 QSARKKKDKSKSKHFDDIR-KPGDESYRKTREDLTTMDKLHMALTELCFAINYCPTVNVWEFAFA 703
            |:..||..|...|..:..| |||.||.||.|..:|.:||||.||:||||:|||.|.:.|||..|.
Human   645 QAVNKKSKKQTGKKGEPEREKPGVESMRKNRLVVTNLDKLHTALSELCFSINYVPNMVVWEHTFT 709

  Fly   704 PREYLCQNLEHRFSRDLVGMVMFNQETMEIAKPSELLASVRAYMNVLQTVENYVHIDITRVFNNC 768
            |||||..:||.||::.:|||.|:||.|.|||||||||.||||||.|||::||||.|||||||||.
Human   710 PREYLTSHLEIRFTKSIVGMTMYNQATQEIAKPSELLTSVRAYMTVLQSIENYVQIDITRVFNNV 774

  Fly   769 LLQQTQALDSHGEKTIAALYNTWYSEVLLRRVSAGNIVFSINQKAFVPISPEGWVPFNPQEFSDL 833
            ||||||.||||||.||.:||..||.|.|||:||.|:|.:....||||.:..|..:.||.:|:||:
Human   775 LLQQTQHLDSHGEPTITSLYTNWYLETLLRQVSNGHIAYFPAMKAFVNLPTENELTFNAEEYSDI 839

  Fly   834 NELRALAELVGPYGIKTLNETLMWHIANQVQELKSLVSTNKEVLITLRTSFDKPEVMKEQFKRLQ 898
            :|:|:|:||:||||:|.|:|:|||||::||.|||.||..|.:||..:|||||||:.|...||||.
Human   840 SEMRSLSELLGPYGMKFLSESLMWHISSQVAELKKLVVENVDVLTQMRTSFDKPDQMAALFKRLS 904

  Fly   899 DVDRVLQRMTIIGVIICFRNLVHEALVDVLDKRIPFLLSSVKDFQEHLPGGDQIRVAS---EMAS 960
            .||.||:||||||||:.||:|..|||.|||...||||:||::||::|:|....::||.   |::|
Human   905 SVDSVLKRMTIIGVILSFRSLAQEALRDVLSYHIPFLVSSIEDFKDHIPRETDMKVAMNVYELSS 969

  Fly   961 AAGLLCKVDPTLATTLKSKKPE--FDEGEHLTACLLMVFVAVSIPKLARNENSFYRATIDGHSNN 1023
            ||||.|::||.|...|.|:|.|  ..|.|:..|||||||||||:|.||.|..|.|...|:||.||
Human   970 AAGLPCEIDPALVVALSSQKSENISPEEEYKIACLLMVFVAVSLPTLASNVMSQYSPAIEGHCNN 1034

  Fly  1024 THCMAAAINNIFGALFTICGQSDMEDRMKEFLALASSSLLRLGQESDKEATRNRESIYLLLDEIV 1088
            .||:|.|||.|..||||| .:..:|||:||||||||||||::|||:||..||||||:|||||.||
Human  1035 IHCLAKAINQIAAALFTI-HKGSIEDRLKEFLALASSSLLKIGQETDKTTTRNRESVYLLLDMIV 1098

  Fly  1089 KQSPFLTMDLLESCFPYVLIRNAYHGVYKQ 1118
            ::|||||||||||||||||:|||||.||||
Human  1099 QESPFLTMDLLESCFPYVLLRNAYHAVYKQ 1128

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hem	NP_524214.1	Nckap1	12..1118	CDD:462866	667/1121 (60%)
NCKAP1	NP_995314.1	Nckap1	13..1128	CDD:462866	667/1121 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	646..671		9/24 (38%)