Protein Alignment Hem and nckap1l

DIOPT Version :10

• Sequence 1: NP_524214.1
• Gene: Hem / 40462
• FlyBaseID: FBgn0011771
• Length: 1126
• Species: Drosophila melanogaster
• Sequence 2: XP_002935704.2
• Gene: nckap1l / 100491829
• XenbaseID: XB-GENE-953118
• Length: 1128
• Species: Xenopus tropicalis
• Alignment Length: 1121
• Identity: 541/1121 - (48%)
• Similarity: 771/1121 - (68%)
• Gaps: 18/1121 - (1%)

  Fly     9 QQKIAEKLIILNDRGLGILTRIYNIKKACGDTKSKPGFLSEKSLESSIKFIVKRFPNIDVKG--- 70
            |.|:||||:||||||.|:|.|||||||.|.:||:||.|.:|||:|||||:|.|:||||||:.
 Frog     8 QHKLAEKLMILNDRGKGVLIRIYNIKKTCSETKTKPPFFTEKSMESSIKYINKKFPNIDVRSSTQ 72

  Fly    71 -LNAIVNIKAEIIKSLSLYYHTFVDLLDFKDNVCELLTTMDACQIHLDITLNFELTKYYLDLVVT 134
             |..:...|:||:|.||.||.:|||:::|:|:|.|||.|:||||.:.||.:|:..||.||||:||
 Frog    73 HLGPVHKEKSEIVKCLSSYYLSFVDVMEFRDHVYELLNTIDACQCYFDININYSFTKSYLDLIVT 137

  Fly   135 YVSLMIVLSRVEDRKAVLGLYNAAYELQNNQADTGFPRLGQMILDYEVPLKKLAEEFIPHQRLLT 199
            |.|:::::||:||||:::.|:|.|.|:....:|..:.||.||:|:|:.|||||:|||.||.:.:|
 Frog   138 YFSVILLMSRIEDRKSLVALFNCASEMLQGHSDPTYARLAQMLLEYDNPLKKLSEEFGPHTKTVT 202

  Fly   200 SALRSLTSIYALRNLPADKWREMQKLSLVGNPAILLKAVRTDTMSCEYISLEAMDRWIIFGLLLN 264
            .||.||..::..|..|||:||..|.|||:.|||.::....:|||.|||:|:|.|:|||:.|.||:
 Frog   203 EALMSLRFLFCRRTQPADQWRGAQLLSLLSNPASMIDPSSSDTMPCEYLSVETMERWIVIGFLLS 267

  Fly   265 HQMLGQYPEVNKIWLSALESSWVVALFRDEVLQIHQYIQATFDGIKGYSKRIGEVKEAYNTAVQK 329
            |..|...|...::|..||:.|..:.|.|||:|.||:..:..|..||||.||:.:|||.....:..
 Frog   268 HGFLNTVPASMELWKLALQGSHCITLIRDEILFIHRVTEDFFGSIKGYGKRVADVKECKEHFMTH 332

  Fly   330 AALMHRERRKFLRTALKELALIMTDQPGLLGPKAIFIFIGLCLARDEILWLLRHNDNPPLLKNKG 394
            ....||.||.|||:|:|||..|::|:||||||||:|.|:.|...||||.||:||.:|    ..|.
 Frog   333 CGQFHRARRFFLRSAVKELEAILSDEPGLLGPKALFAFMALSFCRDEINWLVRHAEN----ITKT 393

  Fly   395 KSNEDLVDRQLPELLFHMEELRALVRKYSQVMQRYYVQYLSGFDATDLNIRMQSLQMCPEDESII 459
            |:.||.||.|:.||:|::|.:||:|:|:..|:|:|::|||:.|||..|:..:|:|.:|||:||:|
 Frog   394 KTPEDYVDVQIAELIFYVEAIRAIVKKHLSVIQKYHIQYLARFDALVLSDVIQNLTVCPEEESVI 458

  Fly   460 FSSLYNTAAALTVKQVEDNELFYFRPFRLDWFRLQTYMSVGKAALRIAEHAELARLLDSMVFHTR 524
            .||..:|.:||:|||||:.|.|.|...||||||||.|.|:.||.|.:.::.:|.::::.::||:.
 Frog   459 MSSFVSTLSALSVKQVENKETFDFCALRLDWFRLQAYTSIAKAPLSLRDNPDLGKVMNLIMFHSW 523

  Fly   525 VVDNLDEILVETSDLSIFCFYNKMFDDQFHMCLEFPAQNRYIIAFPLICSHFQNCTHEMCPEERH 589
            ::|:::|:||||||||.|||:.:.|:..|.|.:|.|:..||.||||||||||.:..|||||||..
 Frog   524 MLDSVEELLVETSDLSAFCFHVRTFEKMFLMTMEEPSALRYSIAFPLICSHFSSSIHEMCPEEYP 588

  Fly   590 HIRERSLSVVNIFLEEMAKEAKNIITTICDEQCTMADALLPKHCAKILSVQSARKKKDKSKSKHF 654
            |::..||...|.||:||:|.|.|....||.|||.:::.|||||||..:| ::..|:..|...|..
 Frog   589 HLKNCSLGFCNNFLDEMSKHASNCAMDICAEQCNLSEKLLPKHCAATIS-KARNKRLKKPPPKRA 652

  Fly   655 DDIR-KPGDESYRKTREDLTTMDKLHMALTELCFAINYCPTVNVWEFAFAPREYLCQNLEHRFSR 718
            :..| |||.||.|:.|...|.:||||:.|.||..|:|:..::.|:|....|.|||..:||:||.|
 Frog   653 EPEREKPGAESQRRDRSVTTNLDKLHLTLCELSMALNHVRSIRVFEHVVTPAEYLSSHLENRFGR 717

  Fly   719 DLVGMVMFNQETMEIAKPSELLASVRAYMNVLQTVENYVHIDITRVFNNCLLQQTQALDSHGEKT 783
            .||.||.|.|.|.||.:|||:|..:|:|::.|:::.:.|:||:||:..:.||||||..|::||.|
 Frog   718 ALVNMVNFKQTTREILRPSEVLHGMRSYLSTLKSIGHLVNIDVTRIIRSSLLQQTQPTDANGEPT 782

  Fly   784 IAALYNTWYSEVLLRRVSAGNIVFSINQKAF--VPISPEGWVPFNPQEFSDLNELRALAELVGPY 846
            |.|||..||.|.|||:.|||.|::|..::.|  :|....|....|.:|:||::|::||:||:|||
 Frog   783 ITALYTNWYLECLLRQASAGFIIYSPARRTFMDLPTEMSGEQGLNAEEYSDVSEMKALSELIGPY 847

  Fly   847 GIKTLNETLMWHIANQVQELKSLVSTNKEVLITLRTSFDKPEVMKEQFKRLQDVDRVLQRMTIIG 911
            |:|.|:|.||||:.:|:.|||.||..|.:||:.:|::|...|:|.....:|...:.:|:||||||
 Frog   848 GMKFLSENLMWHVTSQIVELKKLVIENMDVLVQIRSNFSNSELMPSLLAKLSSPENLLKRMTIIG 912

  Fly   912 VIICFRNLVHEALVDVLDKRIPFLLSSVKDFQEHLPGGDQIRVA---SEMASAAGLLCKVDPTLA 973
            ||:.||.|..|.|.:|.....||::|.::..::.:.....|:|.   .|:|:|||:.|.|||:|.
 Frog   913 VILSFRALTQEGLREVFAHHCPFIMSPIESLKDLVNPDIDIQVTLSIFELATAAGVPCDVDPSLV 977

  Fly   974 TTLKSKKPEFD--EGEHLTACLLMVFVAVSIPKLARNENSFYRATIDGHSNNTHCMAAAINNIFG 1036
            ..|.:.|.:..  |.|:..||||.||:|||:|.||.:..|||....||::||.||:|.||..:..
 Frog   978 AALSNIKTDSASLEEEYKVACLLQVFLAVSLPLLASDPMSFYSIENDGYNNNIHCLAKAIIQVSA 1042

  Fly  1037 ALFTICGQSDMEDRMKEFLALASSSLLRLGQESDKEATRNRESIYLLLDEIVKQSPFLTMDLLES 1101
            ||||:..: ::|..:||||.:||.|||:||:|:||...||||||.:||..||::|.|||:|:|||
 Frog  1043 ALFTLYNK-NIETHLKEFLLMASGSLLQLGEETDKSKARNRESILILLHLIVEESSFLTVDMLES 1106

  Fly  1102 CFPYVLIRNAYHGVYK 1117
            ||||||:|||||.|::
 Frog  1107 CFPYVLLRNAYHEVHR 1122

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hem	NP_524214.1	Nckap1	12..1118	CDD:462866	539/1118 (48%)
nckap1l	XP_002935704.2	Nckap1	11..1123	CDD:462866	539/1118 (48%)