DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Srpk79D and srpk1b

DIOPT Version :9

Sequence 1:	NP_001246881.1	Gene:	Srpk79D / 40461	FlyBaseID:	FBgn0025702	Length:	1018	Species:	Drosophila melanogaster
Sequence 2:	XP_005155715.1	Gene:	srpk1b / 791187	ZFINID:	ZDB-GENE-070112-2292	Length:	643	Species:	Danio rerio

Alignment Length:	770	Identity:	282/770 - (36%)
Similarity:	387/770 - (50%)	Gaps:	158/770 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   270 LSLSLSPPLNRRRDMPALRGPFVSLS------------EPRGTLSTTDEIYPDSSDSSLYVSDEE 322
            |||:..|.|           |.::||            .|||.....|.: .:..:..|...|||
Zfish     3 LSLACQPLL-----------PSLALSLMGIRASCRPDPHPRGAAQQPDAL-QEQDEEILGSDDEE 55

  Fly   323 QEDASQYCRGGYHPVVIGDIFDNRFRVVRKLGWGHFSTVWLCRDLKDEKYVALKVVKSAPHYIET 387
            |||.:.||:||||.|.|||:|:.|:.|:|||||||||||||..|.:.:::||:||||||.||.||
Zfish    56 QEDPNDYCKGGYHHVKIGDLFNGRYHVIRKLGWGHFSTVWLAWDTQGKRFVAMKVVKSAEHYTET 120

  Fly   388 AADEIRLLEAIRDADPMDVKRERIVRLMNHFTVRGVNGMHTCLVFEALGCSLYKLIVKNNYQGLA 452
            |.|||:||:|:|:.|..|..||::|:|::.|.:.||||.|.|:|||.||..|.|.|:|:|||||.
Zfish   121 ALDEIKLLKAVRNTDQNDPSREKVVQLLDDFKISGVNGTHVCMVFEVLGHHLLKWIIKSNYQGLP 185

  Fly   453 IAQVRNIIRQVLEGLDYLHSKCSIIHTDIKPENILLVIDNAAAMNQQIDDEINSLRVKGVDFPDS 517
            :..|::||||||:||||||:||.||||||||||||:                        |..::
Zfish   186 LPCVKSIIRQVLQGLDYLHTKCKIIHTDIKPENILM------------------------DVNEA 226

  Fly   518 YISSIEKQTKSRAKWPLIEPNGSTNTNTNTSNSTATNSNSSTPLAAVIMSTLDKEDTTTTTSSTL 582
            |:..:..:.....|.....|:||            ..|.:..|..|..||.
Zfish   227 YVKRLAAEATEWQKSGAPPPSGS------------AVSTAPAPKQATKMSK-------------- 265

  Fly   583 NSNTTSSLASKYSSLLGDSECNGGLGGSANINNRYRTEKKITAKSSGDCDEDAESDTLGEQSTLA 647
                                           |.:.:.:||          :..:::.|.::....
Zfish   266 -------------------------------NKKKKMKKK----------QKRQAELLEKRILEI 289

  Fly   648 STMDSPTDLDPEPELDSKPNTVPEPSEGPIPEQPTPNSTNSSCPSHNTATIAKSKINSNILSTCT 712
            ..::...|...|.:.|               |..||:||.|...||....|          ||.|
Zfish   290 EGLEKGLDGGEEEDED---------------ETETPDSTPSVPSSHTLQDI----------STET 329

  Fly   713 SLTSTNEYCFTNTNTTTASTPSAPPSATPSSAPALASATPPSTCTPSFTQIAPSATAPATSTT-- 775
            :|..|:|.....|.:.....||.....:......:...||.:..........|:...||.:.|
Zfish   330 TLDGTSEAWSQVTGSVNGHIPSPEDEQSLDVQQQMKDETPVNPYDSGNETSEPTNPYPACNGTEE 394

  Fly   776 ------CTTSAEFYDGDHKTTSTSTTTTSNAISSATTTTATTTTAIAKLNVH--ANAIPSQNQS- 831
                  |.::|   ||:....|....:....:....:.||......|::...  ..|:|.:.:|
Zfish   395 TEPSPACLSAA---DGNGALISGMVESQGCRVQDGESLTAELKDPRAEMEAEPGTQAVPEEEESL 456

  Fly   832 ----QSSQNNTYTIQSLIDNSNVRVKIADLGNACYDYHHFTEDIQTRQYRSIEVLLGAPYNYTAD 892
                .::.|........::...::||||||||||:.:.|||:|||||||||:|||:|..|...||
Zfish   457 KDAKTAAGNLLVNPLEPLNAEKIQVKIADLGNACWVHKHFTDDIQTRQYRSLEVLIGTGYGTPAD 521

  Fly   893 IWSTACLAFELATGDYLFDPHAGESYSRDEDHLAHIVELLGSIPQSVIFRGKHGLKYFTSYGSLR 957
            ||||||:|||||||||||:||:||.|||||||:|.|:||||.||:.::..||:..::||..|.||
Zfish   522 IWSTACMAFELATGDYLFEPHSGEDYSRDEDHIALIIELLGKIPRKLVMNGKYSKEFFTKKGDLR 586

  Fly   958 NITKLKPWSLMNVLVEKYDWDPVEAKKFSDFLLPMLEYNPVIRASAAECLQHPWL 1012
            :|||||||.|.:||||||:|...||:.|||||||||:..|..||:|||||:|.|:
Zfish   587 HITKLKPWGLQDVLVEKYEWHREEAQNFSDFLLPMLDLIPEKRATAAECLRHSWI 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Srpk79D	NP_001246881.1	STKc_SRPK	336..>504	CDD:271038	95/167 (57%)
		S_TKc	347..>492	CDD:214567	89/144 (62%)
		STKc_SRPK	<844..1012	CDD:271038	107/167 (64%)
srpk1b	XP_005155715.1	PKc_like	70..>256	CDD:304357	102/221 (46%)
		S_TKc	80..>224	CDD:214567	90/167 (54%)
		PKc_like	<465..641	CDD:304357	108/175 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1290
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290680at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100556
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.680