Protein Alignment Srpk79D and SRPK2

DIOPT Version :10

• Sequence 1: NP_001246881.1
• Gene: Srpk79D / 40461
• FlyBaseID: FBgn0025702
• Length: 1018
• Species: Drosophila melanogaster
• Sequence 2: XP_024302662.1
• Gene: SRPK2 / 6733
• HGNCID: 11306
• Length: 767
• Species: Homo sapiens
• Alignment Length: 772
• Identity: 287/772 - (37%)
• Similarity: 396/772 - (51%)
• Gaps: 157/772 - (20%)

  Fly   305 DEIYPDSSDSSLYVSDEEQEDASQYCRGGYHPVVIGDIFDNRFRVVRKLGWGHFSTVWLCRDLKD 369
            |...|:..:..|...||||||.:.||:||||||.|||:|:.|:.|:||||||||||||||.|::.
Human    87 DPTPPEPEEEILGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQG 151

  Fly   370 EKYVALKVVKSAPHYIETAADEIRLLEAIRDADPMDVKRERIVRLMNHFTVRGVNGMHTCLVFEA 434
            :::||:||||||.||.|||.|||:||:.:|::||.|..::.:|:|::.|.:.|:||:|.|:|||.
Human   152 KRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEV 216

  Fly   435 LGCSLYKLIVKNNYQGLAIAQVRNIIRQVLEGLDYLHSKCSIIHTDIKPENILLVIDNAAAMNQQ 499
            ||..|.|.|:|:|||||.:..|::||||||:|||||||||.||||||||||||:.:|:|..  ::
Human   217 LGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYV--RR 279

  Fly   500 IDDEINSLRVKGVDFPDSYISSIEKQTKSRAKWPLIEPNGSTNTNTNTSNSTATNSNSSTPLAAV 564
            :..|....:..|...|.....|...|.|         |.|..:.|............     |.:
Human   280 MAAEATEWQKAGAPPPSGSAVSTAPQQK---------PIGKISKNKKKKLKKKQKRQ-----AEL 330

  Fly   565 IMSTLD--KEDTTTTTSSTLNSNTTSSLASKYSSLLGDSECNGGLGGSANINNRYRTEKKI---- 623
            :...|.  :|.........:..|.||:..|.                  :.:..|..|.|:
Human   331 LEKRLQEIEELEREAERKIIEENITSAAPSN------------------DQDGEYCPEVKLKTTG 377

  Fly   624 --------TAKSSGDCD-----EDAESDTLGEQSTLASTMDSPTDLDPE-----PELDSKPNTVP 670
                    |||.:|:.:     ||||.:.:.:..         .|:|.|     |.....|.|..
Human   378 LEEAAEAETAKDNGEAEDQEEKEDAEKENIEKDE---------DDVDQELANIDPTWIESPKTNG 433

  Fly   671 EPSEGPIP-EQPTPNSTN--SSCPSHNTATIAKSKINSNILSTCTSLTSTNEYCFTNT-NTTTAS 731
            ....||.. ||...:..:  ..||:.....:.:....|             :|.:::: ......
Human   434 HIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDEPNAES-------------DYTYSSSYEQFNGE 485

  Fly   732 TPSA----PPSATPSSAPALASAT-PPSTCTPSFTQIAPSATAPATSTTCTTSAEFYDGDHKTTS 791
            .|:.    |.|..|..:.:|.|.: .|..|....::.:|           .|..|.....|..:.
Human   486 LPNGRHKIPESQFPEFSTSLFSGSLEPVACGSVLSEGSP-----------LTEQEESSPSHDRSR 539

  Fly   792 TSTTTTSNAISSATTTTATTTTAIAKLNVHANAIPSQNQSQSSQNNTYTIQSLIDNSNVRVKIAD 856
            |.:.:::..:..|.|..|         ::..|.:..:|..:                 :||||||
Human   540 TVSASSTGDLPKAKTRAA---------DLLVNPLDPRNADK-----------------IRVKIAD 578

  Fly   857 LGNACYDYHHFTEDIQTRQYRSIEVLLGAPYNYTADIWSTACLAFELATGDYLFDPHAGESYSRD 921
            |||||:.:.|||||||||||||||||:||.|:..||||||||:|||||||||||:||:||.||||
Human   579 LGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRD 643

  Fly   922 EDHLAHIVELLGSIPQ-------------------SVIFR------------GKHGLKYFTSYGS 955
            |||:|||:|||||||:                   ::|..            ||:..::||..|.
Human   644 EDHIAHIIELLGSIPRHFALSGKYSREFFNRRDHIALIIELLGKVPRKYAMLGKYSKEFFTRKGE 708

  Fly   956 LRNITKLKPWSLMNVLVEKYDWDPVEAKKFSDFLLPMLEYNPVIRASAAECLQHPWL 1012
            ||:|||||||||.:||||||.|...:|.:|:|||:||||..|..||||.|||:||||
Human   709 LRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWL 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Srpk79D	NP_001246881.1	Protein Kinases, catalytic domain	336..>504	CDD:473864	97/167 (58%)
		PHA03307	627..>759	CDD:223039	27/150 (18%)
		Protein Kinases, catalytic domain	<844..1012	CDD:473864	114/198 (58%)
SRPK2	XP_024302662.1	Protein Kinases, catalytic domain	116..>304	CDD:473864	103/189 (54%)
		2A1904	<389..431	CDD:273344	10/50 (20%)
		Protein Kinases, catalytic domain	<552..765	CDD:473864	119/238 (50%)