DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Srpk79D and SRPK2

DIOPT Version :9

Sequence 1:	NP_001246881.1	Gene:	Srpk79D / 40461	FlyBaseID:	FBgn0025702	Length:	1018	Species:	Drosophila melanogaster
Sequence 2:	XP_024302662.1	Gene:	SRPK2 / 6733	HGNCID:	11306	Length:	767	Species:	Homo sapiens

Alignment Length:	772	Identity:	287/772 - (37%)
Similarity:	396/772 - (51%)	Gaps:	157/772 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   305 DEIYPDSSDSSLYVSDEEQEDASQYCRGGYHPVVIGDIFDNRFRVVRKLGWGHFSTVWLCRDLKD 369
            |...|:..:..|...||||||.:.||:||||||.|||:|:.|:.|:||||||||||||||.|::.
Human    87 DPTPPEPEEEILGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQG 151

  Fly   370 EKYVALKVVKSAPHYIETAADEIRLLEAIRDADPMDVKRERIVRLMNHFTVRGVNGMHTCLVFEA 434
            :::||:||||||.||.|||.|||:||:.:|::||.|..::.:|:|::.|.:.|:||:|.|:|||.
Human   152 KRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEV 216

  Fly   435 LGCSLYKLIVKNNYQGLAIAQVRNIIRQVLEGLDYLHSKCSIIHTDIKPENILLVIDNAAAMNQQ 499
            ||..|.|.|:|:|||||.:..|::||||||:|||||||||.||||||||||||:.:|:|..  ::
Human   217 LGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYV--RR 279

  Fly   500 IDDEINSLRVKGVDFPDSYISSIEKQTKSRAKWPLIEPNGSTNTNTNTSNSTATNSNSSTPLAAV 564
            :..|....:..|...|.....|...|.|         |.|..:.|............     |.:
Human   280 MAAEATEWQKAGAPPPSGSAVSTAPQQK---------PIGKISKNKKKKLKKKQKRQ-----AEL 330

  Fly   565 IMSTLD--KEDTTTTTSSTLNSNTTSSLASKYSSLLGDSECNGGLGGSANINNRYRTEKKI---- 623
            :...|.  :|.........:..|.||:..|.                  :.:..|..|.|:
Human   331 LEKRLQEIEELEREAERKIIEENITSAAPSN------------------DQDGEYCPEVKLKTTG 377

  Fly   624 --------TAKSSGDCD-----EDAESDTLGEQSTLASTMDSPTDLDPE-----PELDSKPNTVP 670
                    |||.:|:.:     ||||.:.:.:..         .|:|.|     |.....|.|..
Human   378 LEEAAEAETAKDNGEAEDQEEKEDAEKENIEKDE---------DDVDQELANIDPTWIESPKTNG 433

  Fly   671 EPSEGPIP-EQPTPNSTN--SSCPSHNTATIAKSKINSNILSTCTSLTSTNEYCFTNT-NTTTAS 731
            ....||.. ||...:..:  ..||:.....:.:....|             :|.:::: ......
Human   434 HIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDEPNAES-------------DYTYSSSYEQFNGE 485

  Fly   732 TPSA----PPSATPSSAPALASAT-PPSTCTPSFTQIAPSATAPATSTTCTTSAEFYDGDHKTTS 791
            .|:.    |.|..|..:.:|.|.: .|..|....::.:|           .|..|.....|..:.
Human   486 LPNGRHKIPESQFPEFSTSLFSGSLEPVACGSVLSEGSP-----------LTEQEESSPSHDRSR 539

  Fly   792 TSTTTTSNAISSATTTTATTTTAIAKLNVHANAIPSQNQSQSSQNNTYTIQSLIDNSNVRVKIAD 856
            |.:.:::..:..|.|..|         ::..|.:..:|..:                 :||||||
Human   540 TVSASSTGDLPKAKTRAA---------DLLVNPLDPRNADK-----------------IRVKIAD 578

  Fly   857 LGNACYDYHHFTEDIQTRQYRSIEVLLGAPYNYTADIWSTACLAFELATGDYLFDPHAGESYSRD 921
            |||||:.:.|||||||||||||||||:||.|:..||||||||:|||||||||||:||:||.||||
Human   579 LGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRD 643

  Fly   922 EDHLAHIVELLGSIPQ-------------------SVIFR------------GKHGLKYFTSYGS 955
            |||:|||:|||||||:                   ::|..            ||:..::||..|.
Human   644 EDHIAHIIELLGSIPRHFALSGKYSREFFNRRDHIALIIELLGKVPRKYAMLGKYSKEFFTRKGE 708

  Fly   956 LRNITKLKPWSLMNVLVEKYDWDPVEAKKFSDFLLPMLEYNPVIRASAAECLQHPWL 1012
            ||:|||||||||.:||||||.|...:|.:|:|||:||||..|..||||.|||:||||
Human   709 LRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWL 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Srpk79D	NP_001246881.1	STKc_SRPK	336..>504	CDD:271038	97/167 (58%)
		S_TKc	347..>492	CDD:214567	88/144 (61%)
		STKc_SRPK	<844..1012	CDD:271038	114/198 (58%)
SRPK2	XP_024302662.1	STKc_SRPK2	116..>304	CDD:271119	103/189 (54%)
		Na_Ca_ex	<389..431	CDD:332332	10/50 (20%)
		PKc_like	<552..765	CDD:328722	119/238 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1290
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290680at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100556
Panther	1	1.100	-	-	O	PTHR24055
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.780