Protein Alignment Srpk79D and Srpk1

DIOPT Version :10

• Sequence 1: NP_001246881.1
• Gene: Srpk79D / 40461
• FlyBaseID: FBgn0025702
• Length: 1018
• Species: Drosophila melanogaster
• Sequence 2: NP_058075.2
• Gene: Srpk1 / 20815
• MGIID: 106908
• Length: 648
• Species: Mus musculus
• Alignment Length: 729
• Identity: 281/729 - (38%)
• Similarity: 393/729 - (53%)
• Gaps: 121/729 - (16%)

  Fly   295 SEPRGTLSTTDEIYPDSSDSSLYVSDEEQEDASQYCRGGYHPVVIGDIFDNRFRVVRKLGWGHFS 359
            ::.||:...::...|:..:..|...|:||||.:.||:||||.|.|||:|:.|:.|:|||||||||
Mouse    28 TQHRGSAPHSESDIPEQEEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFS 92

  Fly   360 TVWLCRDLKDEKYVALKVVKSAPHYIETAADEIRLLEAIRDADPMDVKRERIVRLMNHFTVRGVN 424
            ||||..|::.:|:||:||||||.||.|||.||||||:::|::||.|...|.:|:|::.|.:.|||
Mouse    93 TVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNGEMVVQLLDDFKISGVN 157

  Fly   425 GMHTCLVFEALGCSLYKLIVKNNYQGLAIAQVRNIIRQVLEGLDYLHSKCSIIHTDIKPENILLV 489
            |.|.|:|||.||..|.|.|:|:|||||.:..|:.||:|||:||||||:||.|||||||||||||
Mouse   158 GTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILL- 221

  Fly   490 IDNAAAMNQQIDDEINSLRVKGVDFPDSYISSIEKQTKSRAKWPLIEPNGSTNTNTNTSNSTATN 554
                 ::|:|                  ||..:..:.....:.....|:||       :.|||..
Mouse   222 -----SVNEQ------------------YIRRLAAEATEWQRSGAPPPSGS-------AVSTAPQ 256

  Fly   555 SNSSTPLAAVIMSTLDKEDTTTTTSSTLNSNTTSSLASKYSSLLGDSECNGGLGGSANINNRYRT 619
            ...:..::......|.|:           ....:.|..|....:.:.|...| .|....|.:..:
Mouse   257 PKPADKMSKNKKKKLKKK-----------QKRQAELLEKRMQEIEEMEKESG-PGQKRPNKQEES 309

  Fly   620 E----KKITAKSSGDCDED--AESDTLGEQSTLASTMDSPTDLDPE---PELDSKPNTVPEPSEG 675
            |    :.:|........::  .||:::|:..||       |:...|   ||::         ..|
Mouse   310 ESPVDRPLTENPPNKMTQEKLEESNSIGQDQTL-------TERGGEGGAPEIN---------CNG 358

  Fly   676 PIPEQPTPNSTNSSCPSHNTATIAKSKINSNILSTCTSLTSTNEYCFTNTNTTTASTPSAPPSAT 740
            .|.....|.::|:....|.     :...|:|   .|...|...|..|.|::...:|......|.|
Mouse   359 VIGVVNYPENSNNETLRHK-----EDLHNAN---DCDVHTLKQEPSFLNSSNGDSSPSQDTDSCT 415

  Fly   741 PSSAPALA--SATPPSTCTPSFTQIAPSATAPATSTTCTTSAEFYDGDHKTTSTSTTTTSNAISS 803
            |:::..:.  |:...|......||:..|..|...|           ||.:       ..:.|:.|
Mouse   416 PTASETMVCQSSAEQSLTRQDITQLEESIRADTPS-----------GDEQ-------EPNGALDS 462

  Fly   804 ATTTTATTTTAIAKLNVHANAIPSQNQSQSSQNNTYTIQSLIDNSNVRVKIADLGNACYDYHHFT 868
            ....:|.        |...|.:..:|..:                 ::||||||||||:.:.|||
Mouse   463 KGKFSAG--------NFLINPLEPKNAEK-----------------LQVKIADLGNACWVHKHFT 502

  Fly   869 EDIQTRQYRSIEVLLGAPYNYTADIWSTACLAFELATGDYLFDPHAGESYSRDEDHLAHIVELLG 933
            ||||||||||:|||:|:.||..||||||||:|||||||||||:||:||.|:|||||:|.|:||||
Mouse   503 EDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEDYTRDEDHIALIIELLG 567

  Fly   934 SIPQSVIFRGKHGLKYFTSYGSLRNITKLKPWSLMNVLVEKYDWDPVEAKKFSDFLLPMLEYNPV 998
            .:|:.:|..||:..::||..|.|::|||||||.|:.||||||:|...||..|:||||||||..|.
Mouse   568 KVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLLEVLVEKYEWPQEEAAGFTDFLLPMLELMPE 632

  Fly   999 IRASAAECLQHPWL 1012
            .||:|||||:||||
Mouse   633 KRATAAECLRHPWL 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Srpk79D	NP_001246881.1	Protein Kinases, catalytic domain	336..>504	CDD:473864	98/167 (59%)
		PHA03307	627..>759	CDD:223039	27/138 (20%)
		Protein Kinases, catalytic domain	<844..1012	CDD:473864	108/167 (65%)
Srpk1	NP_058075.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..57		6/28 (21%)
		Protein Kinases, catalytic domain	70..646	CDD:473864	264/685 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	238..354		24/141 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	395..464		17/86 (20%)
		Protein Kinases, catalytic domain	<470..537	CDD:473864	42/83 (51%)