Protein Alignment Ddx1 and DDX1

DIOPT Version :10

• Sequence 1: NP_524212.2
• Gene: Ddx1 / 40457
• FlyBaseID: FBgn0015075
• Length: 727
• Species: Drosophila melanogaster
• Sequence 2: NP_004930.1
• Gene: DDX1 / 1653
• HGNCID: 2734
• Length: 740
• Species: Homo sapiens
• Alignment Length: 737
• Identity: 438/737 - (59%)
• Similarity: 558/737 - (75%)
• Gaps: 25/737 - (3%)

  Fly     1 MTAFEEFGVLPELGMATDELDWTLPTDVQAEAIPLILGGGDVLMAAETGSGKTGAFCLPILQIVW 65
            |.||.|.||:||:..|.:|:||.||||:|||:||||||||||||||||||||||||.:|::|||:
Human     1 MAAFSEMGVMPEIAQAVEEMDWLLPTDIQAESIPLILGGGDVLMAAETGSGKTGAFSIPVIQIVY 65

  Fly    66 ETLRDLEEGKAGKGGAIGGA--VTPWTMSFFDRGNALAVTPDGLRCQSREFKEWHGCRATTGVRG 128
            |||:|.:|||.||.....||  :..|.|:.:|||:|.|:..|||.|||||.|||||||||.|:.
Human    66 ETLKDQQEGKKGKTTIKTGASVLNKWQMNPYDRGSAFAIGSDGLCCQSREVKEWHGCRATKGLM- 129

  Fly   129 KGKFYFEATVTDEGLCRVGWSTQQANLDLGTCRMGFGFGGTGKKSNNRQFDDYGEAFGKADVIGC 193
            |||.|:|.:..|:|||||||||.||:|||||.:.|||||||||||:|:|||:|||.|...|.|||
Human   130 KGKHYYEVSCHDQGLCRVGWSTMQASLDLGTDKFGFGFGGTGKKSHNKQFDNYGEEFTMHDTIGC 194

  Fly   194 LLDLKNQEVSFTKNGQNLGVAFRLPDNLAKETFYPAVVLKNAEMQFNFGKTDFKYAPGNGFVGAC 258
            .||:....|.|:|||::||:||.:|.::..:..:||.||||||::||||:.:||:.|.:|||...
Human   195 YLDIDKGHVKFSKNGKDLGLAFEIPPHMKNQALFPACVLKNAELKFNFGEEEFKFPPKDGFVALS 259

  Fly   259 QA------GPEHSKANPITGPAAGAPSAKPAPNAPQAIIMEPSRELAEQTYNQIEKFKYHLSNPE 317
            :|      ..:||....:|       ..|..||||:|:|:||||||||||.|.|::||.::.||:
Human   260 KAPDGYIVKSQHSGNAQVT-------QTKFLPNAPKALIVEPSRELAEQTLNNIKQFKKYIDNPK 317

  Fly   318 VRSLLLIGGVRLEEQKAQLMQGTHIVVGTPGRLEEMINSGLVLLTHCRFFVLDEADALLKQGYTE 382
            :|.||:||||...:|.:.|..|..|||||||||::::::|.:.|:..||.||||||.||.|||::
Human   318 LRELLIIGGVAARDQLSVLENGVDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLSQGYSD 382

  Fly   383 LIDRLHKQIPKITSDGRRLQMVVCSATLHAFEVKKMAERLMHFPTWVDLKGEDAVPETVHHVVCL 447
            .|:|:|.|||::||||:|||::|||||||:|:|||::|::|||||||||||||:||:||||||..
Human   383 FINRMHNQIPQVTSDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWVDLKGEDSVPDTVHHVVVP 447

  Fly   448 VDPQMDTTWQSL-RQPIGTDGVHDRDNVHPGNHSKETLSQAVKLLKGEYCVHAIDKHNMDRAIIF 511
            |:|:.|..|:.| :..|.||.||.:||..||.:|.|..|:|:|:|||||.|.||.:|.||:||||
Human   448 VNPKTDRLWERLGKSHIRTDDVHAKDNTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIF 512

  Fly   512 CRTKQDCDNLERFLRQRG------GKHYSCVCLHGDRKPQERKENLEMFKRQQVKFLICTDVAAR 570
            ||||.||||||::..|:|      |..:|||||||||||.|||:|||.||:..|:||||||||||
Human   513 CRTKIDCDNLEQYFIQQGGGPDKKGHQFSCVCLHGDRKPHERKQNLERFKKGDVRFLICTDVAAR 577

  Fly   571 GLDITGLPFMINVTLPDDKTNYVHRIGRVGRAERMGLAISLVATVPEKVWYHGEWCKSRGRSCNN 635
            |:||.|:|::|||||||:|.||||||||||||||||||||||||..||||||  .|.|||:.|.|
Human   578 GIDIHGVPYVINVTLPDEKQNYVHRIGRVGRAERMGLAISLVATEKEKVWYH--VCSSRGKGCYN 640

  Fly   636 TNLTEVRGCCIWYNEPNLLAEVEDHLNITIQQVDKTMDVPVNDFDGKVVYGQKNLRTGSGYEDHV 700
            |.|.|..||.|||||..||:|:|:|||.||.||:..:.|||::|||||.||||....|..|:.||
Human   641 TRLKEDGGCTIWYNEMQLLSEIEEHLNCTISQVEPDIKVPVDEFDGKVTYGQKRAAGGGSYKGHV 705

  Fly   701 EQLVPTVRKLTELELQSQSLFL 722
            :.|.|||::|..||.::|:.||
Human   706 DILAPTVQELAALEKEAQTSFL 727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ddx1	NP_524212.2	DEAD-like_helicase_N	4..>73	CDD:475120	49/68 (72%)
		SPRY_DDX1	91..242	CDD:293933	91/150 (61%)
		SrmB	283..613	CDD:440279	213/336 (63%)
DDX1	NP_004930.1	Necessary for interaction with RELA. /evidence=ECO:0000269|PubMed:19058135	1..525		309/531 (58%)
		Interaction with dsRNA. /evidence=ECO:0000250|UniProtKB:Q91VR5	1..448		265/454 (58%)
		Necessary for interaction with HNRNPK. /evidence=ECO:0000269|PubMed:12183465	1..295		170/301 (56%)
		DEAD-like_helicase_N	4..>64	CDD:475120	43/59 (73%)
		SPRY_DDX1	93..245	CDD:293933	93/152 (61%)
		SrmB	284..625	CDD:440279	216/340 (64%)
		DEAD box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541	370..373		2/2 (100%)
		Necessary for interaction with HNRNPK. /evidence=ECO:0000269|PubMed:12183465	525..740		129/205 (63%)
		Necessary for interaction with replicase polyprotein 1ab nsp14 of IBV. /evidence=ECO:0000269|PubMed:20573827	536..631		74/96 (77%)