DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment olf413 and CG5235

DIOPT Version :9

Sequence 1:	NP_001262204.1	Gene:	olf413 / 40453	FlyBaseID:	FBgn0037153	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_001261921.1	Gene:	CG5235 / 39758	FlyBaseID:	FBgn0036565	Length:	698	Species:	Drosophila melanogaster

Alignment Length:	697	Identity:	193/697 - (27%)
Similarity:	297/697 - (42%)	Gaps:	127/697 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 WQIINQD-ITFEIQARTLGYVGFGFSPDGNLAGADMAIGWVD--KGQTYFQDRH-VTRNGDPEPV 183
            |...|:: |.||:...|.|:.|.|||.||.||.|||.:.|||  .|.....|.| ........|:
  Fly    61 WINANENSIYFEVTVHTRGFAGLGFSKDGRLARADMVLMWVDDATGHPNVLDCHGALHPSSGPPL 125

  Fly   184 VDPSQDYMLMLGYENATHTVLRFRRKLDTCDPSHDIAITNDTMRLLYMYHAQDPPHGSVRPGTLP 248
            .|.:|:|.::.|.:|.|||:|:|:||::|||| .||.::.||.::|:.....||.||::......
  Fly   126 QDDTQNYDVLDGKQNGTHTILKFKRKIETCDP-FDIPLSADTFKVLWSIGENDPIHGNLDWQGQS 189

  Fly   249 DPARAFRPYRPMVLMQRAQLPMPSPTHDERVRVLELRNEDVELPAGDLPLFWCKMFKLEDINRKH 313
            ...:|.:.:.||.......:        |.::..::...:|.:......|:|||:.:|.::..|.
  Fly   190 RGVKALQLFSPMFTKNSHSI--------EGIQKWDITVNNVTIDRSMDTLYWCKIVRLPELTGKQ 246

  Fly   314 HLIRYEPIYDSSSSVHYLQHITLHECQ-----GAHAELEEM-AREQGRPCLGARSIPL---ACNA 369
            |:|.|||:.......:.:.|:||.|||     |:.....:: .|..|..|......|.   :|:.
  Fly   247 HIIGYEPLLSGKYERNVVHHMTLFECQSKIYSGSDPSSWDLWVRSAGTVCNSNLLTPRDWDSCST 311

  Fly   370 IVASWSRGSEGFTYPHEAGYPIESRQ-AKYYLMETHYNNLKPDFAQLHARQMADNSGLKIYFTHV 433
            .||.||.||:|...|..||.|:.... ..||::|.||:|  ||     .::..|:||.:|::|..
  Fly   312 PVAVWSLGSDGQFLPPHAGIPMGGASGVSYYMLEIHYDN--PD-----GKESVDHSGFRIHYTPN 369

  Fly   434 LRPNDAGTLSIGMDPNWRHIIPPGQKRVVSEGQCIEDCTGYAFPQQGINIFAVMMRTHQIGKEVK 498
            ||..|:|.|..|:..:...:||||||:..|.|.|...|:...||:.||.|.:..:.:||.|:.:.
  Fly   370 LRTYDSGILISGVSISETQLIPPGQKKYRSVGICGPSCSSVMFPKDGIKIISGTLHSHQAGRTIS 434

  Fly   499 LRQIRQTEELPPIAHDSNIDVAYQDFRRLPQSVHSMPGDRLIAECIYDSSSRKAITLGGLTMKEE 563
            ||.:|..:||.||..|.|.|..:|...:|......:|||.||.:|.|::..||..|.||.:.|||
  Fly   435 LRHVRSGKELNPIIVDENYDYRHQKVHQLANETVVLPGDYLITDCSYETKYRKRPTFGGYSTKEE 499

  Fly   564 SCTVLTLYYPRQKKLTTCHSLPSLPTVLHSLGIEQL---------------------------AT 601
            .|.....|||: .:::.|:|:..:........:.|.                           ||
  Fly   500 MCLTFITYYPK-IEMSGCYSMTPVREFFEMFRVYQFYSLNMTDVENMFLYNSDYTDYSKQAKNAT 563

  Fly   602 DS------------------NPVLISSPPELAGMTLEARLISYDWENQF--GEFQEATRKGSFKP 646
            :.                  |.::||.|.|....|..:.|....|.:..  ...::|...|:...
  Fly   564 NKPNSGKTSKEDVIYQESLLNKLVISDPAEFHDRTFLSHLNQLPWHDPLFTKRVEQAFITGTHMT 628

  Fly   647 ICWGAKNHVVPGSEFLEGYSINVTKTYKKHRRCKPKRPLAPPTERTAPPPASDLSELPVLHELDN 711
            .|..:|:.:...||.:.                      .|.......|||:.|:.|
  Fly   629 FCRVSKDSLSIPSEIIR----------------------YPEFTAYVKPPAACLNYL-------- 663

  Fly   712 NNIIEGAARSSRSSATDVHSLSRGSGRHFISCLLWLGASSWWLLLML 758
                          .||...|..||.:.|....|     |..||:.|
  Fly   664 --------------FTDNEELRSGSSQFFTDFTL-----SLLLLIQL 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
olf413	NP_001262204.1	DOMON_DOH	111..243	CDD:187689	50/123 (41%)
		Cu2_monooxygen	282..407	CDD:279429	40/134 (30%)
		Cu2_monoox_C	438..583	CDD:281675	54/144 (38%)
CG5235	NP_001261921.1	DOMON	54..174	CDD:281361	46/113 (41%)
		Cu2_monooxygen	214..354	CDD:279429	43/146 (29%)
		Cu2_monoox_C	374..529	CDD:281675	55/155 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463766
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3568
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1472750at2759
OrthoFinder	1	1.000	-	-		FOG0002519
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101678
Panther	1	1.100	-	-	P	PTHR10157
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4667
SonicParanoid	1	1.000	-	-		X2216
	9	8.780