DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PolH and POLH

DIOPT Version :10

Sequence 1:NP_649371.2 Gene:PolH / 40438 FlyBaseID:FBgn0037141 Length:885 Species:Drosophila melanogaster
Sequence 2:NP_568638.2 Gene:POLH / 834503 AraportID:AT5G44740 Length:672 Species:Arabidopsis thaliana


Alignment Length:782 Identity:240/782 - (30%)
Similarity:351/782 - (44%) Gaps:138/782 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 RVVLLVDMDCFFCQVEEKQHPEYRNRPLAVVQYNPWRGGGIIAVNYAARAKGVTRHMRGDEAKDL 80
            ||:..||||||:.|||:::.||.|..|.||||||.|:|||:|||:|.||..||.|.|||||||..
plant    12 RVIAHVDMDCFYVQVEQRKQPELRGLPSAVVQYNEWQGGGLIAVSYEARKCGVKRSMRGDEAKAA 76

  Fly    81 CPEIVLCQVPNIREKADTSKYRDAGKEVANVLQRFTQLLERASVDEAYLDITETVNHRMQQMQSG 145
            ||:|.|.|||..|.|||.:.||.||.||.::|.: :...||||:||.|||:|:.....:......
plant    77 CPQIQLVQVPVARGKADLNLYRSAGSEVVSILAK-SGKCERASIDEVYLDLTDAAESMLADAPPE 140

  Fly   146 AFALQPQELVNTFAVGYPSIGDYVNKITNRFANPYMDDERYQMSYDQNDLPAVRQSDIRLLIGAS 210
            :..|..:|::.:..:|          :.....:.:.:..|..:..:..|     :.|..|..|..
plant   141 SLELIDEEVLKSHILG----------MNREDGDDFKESVRNWICREDAD-----RRDKLLSCGII 190

  Fly   211 VAGEVRAAVKKETGYECSAGIAHNKILAKLAAGMNKPNKQTILPLTETASLFDSLPVGKIKGLGG 275
            :..|:|..|.|||.:.|||||||||:|||||:|||||.:||::|......|..|||:.|:|.|||
plant   191 IVAELRKQVLKETEFTCSAGIAHNKMLAKLASGMNKPAQQTVVPYAAVQELLSSLPIKKMKQLGG 255

  Fly   276 KFGEVVCETLGIKFMGQVVKFSEVDLQRKFDEKNGTWLFNISRGIDLEAVTPRFYSKSIGCCKKF 340
            |.|..:...||:..:|.:::|||..||..:....||||:||:|||..|.|..|...||.|..|.|
plant   256 KLGTSLQTDLGVDTVGDLLQFSETKLQEHYGVNTGTWLWNIARGISGEEVQGRLLPKSHGSGKTF 320

  Fly   341 PGRNNITGLKTLQHWLGELSSEINDRLEKDFIENNRRAK----HMVVQYVQDIDGEEVASSRSTA 401
            ||...:..|.|:||||.:||.|:::||..|..:|.|.|.    |......:|.|..:...|:|..
plant   321 PGPRALKSLSTVQHWLNQLSEELSERLGSDLEQNKRIASTLTLHASAFRSKDSDSHKKFPSKSCP 385

  Fly   402 LRDYDQESIVRLSLDLIKANTKTF-----LRPGSESALNNAIKFLGISVGKFETVSSGQNKLQEM 461
            :| |....|...:.:|.:|..:.:     ::|.........|..|.:|..|...:.||.:.:...
plant   386 MR-YGVTKIQEDAFNLFQAALREYMGSFGIKPQGNKLETWRITGLSVSASKIVDIPSGTSSIMRY 449

  Fly   462 FANQAAKKRRVSGDEPGQLPKVEMEKKQKQTDEFKMKSFFANYLQGAKKEDAKADGISANPLAAA 526
            |.:|.....|                                          .|||.....:|..
plant   450 FQSQPTVPSR------------------------------------------SADGCVQGNVAMT 472

  Fly   527 AGAPNKNFVEEYKHKLHAAVRTEGTVLTSTPAEFKESFFSQYLKQQKKTGQQGSVTSREDSLDVQ 591
            |.| ::...|:...:..||:....|.:|.|...|:        .|.|               |: 
plant   473 ASA-SEGCSEQRSTETQAAMPEVDTGVTYTLPNFE--------NQDK---------------DI- 512

  Fly   592 ELAEELDAIEADNSKDFEEDTEEETELTSDTHMSKPEGQSSDAGQEQD---PNTLNDSTGNDLYV 653
            :|..|.|.:...:::..:..|:.|:...:.|   |..|:..:..:|::   |:.:      |::.
plant   513 DLVSEKDVVSCPSNEATDVSTQSESNKGTQT---KKIGRKMNNSKEKNRGMPSIV------DIFK 568

  Fly   654 ETGIVPPT---LTEDELKPSTSKRKFDEIESSVSNYKECYVEFAVPNLR-TDILPTIKCDQCGAN 714
            .....||:   ..||....|.|||.  ::.||..|.:   |...|...| ||.  ..|.|:...:
plant   569 NYNATPPSKQETQEDSTVSSASKRA--KLSSSSHNSQ---VNQEVEESRETDW--GYKTDEIDQS 626

  Fly   715 IPDEVKSLQTHRDHHFAQELSRTLRSTEREERTQSRQKISLKPTPPKKSKKTAGSGSSSYSTAPP 779
            :.||:           ..|:.|.|||..|..:..:..|           .|..||.||.....||
plant   627 VFDEL-----------PVEIQRELRSFLRTNKQFNTGK-----------SKGDGSTSSIAHYFPP 669

  Fly   780 SN 781
            .|
plant   670 LN 671

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PolHNP_649371.2 PolY_Pol_eta 20..447 CDD:176456 170/435 (39%)
zf_UBZ 705..736 CDD:465769 5/30 (17%)
zf_UBZ 805..832 CDD:465769
POLHNP_568638.2 PolY_Pol_eta 15..435 CDD:176456 170/436 (39%)
Rev1_UBM2 <623..641 CDD:412037 5/28 (18%)
Blue background indicates that the domain is not in the aligned region.

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