Protein Alignment PolH and polh

DIOPT Version :10

• Sequence 1: NP_649371.2
• Gene: PolH / 40438
• FlyBaseID: FBgn0037141
• Length: 885
• Species: Drosophila melanogaster
• Sequence 2: NP_001035337.2
• Gene: polh / 678520
• ZFINID: ZDB-GENE-060421-4949
• Length: 749
• Species: Danio rerio
• Alignment Length: 893
• Identity: 264/893 - (29%)
• Similarity: 419/893 - (46%)
• Gaps: 172/893 - (19%)

  Fly    15 DRVVLLVDMDCFFCQVEEKQHPEYRNRPLAVVQYNPWRGGGIIAVNYAARAKGVTRHMRGDEAKD 79
            :|||.|||||||:.|||::..||.:|:|..|.||..|:|||||||:|.|||.||.|:|..|:|:.
Zfish     6 ERVVALVDMDCFYVQVEQRLKPELKNKPCVVAQYKTWKGGGIIAVSYEARAHGVGRNMFADDARK 70

  Fly    80 LCPEIVLCQVPNIREKADTSKYRDAGKEVANVLQRFTQLLERASVDEAYLDITETVNHRMQQMQS 144
            |||::.:.:||....|||.:.||:|..||..|:.||. ::||||:||||:|:|.:|..|::  .:
Zfish    71 LCPDLQVARVPEAHGKADLTHYREASVEVIEVMSRFA-VIERASIDEAYMDLTASVQERLK--NT 132

  Fly   145 GAFALQPQELVNTFAVGYPSIGDYVNKITNRFANPYMDDERYQMSYDQNDLPAVRQS------DI 203
            ....:..|:|.||...|:|:          :..|.::|.:..:.:..|..|..:..|      |:
Zfish   133 SVQDITAQQLKNTHIQGFPT----------QQENTHLDRDAQRAAGLQQWLDLLSSSTESSPADL 187

  Fly   204 RLLIGASVAGEVRAAVKKETGYECSAGIAHNKILAKLAAGMNKPNKQTILPLTETASLFDSLPVG 268
            ||.:||.:..::||||::.||:.|||||:|||:|||||.|:||||:||:|||:....||.:||:.
Zfish   188 RLAVGALIVEQMRAAVEEHTGFRCSAGISHNKVLAKLACGLNKPNRQTVLPLSSVPQLFSTLPIS 252

  Fly   269 KIKGLGGKFGEVVCETLGIKFMGQVVKFSEVDLQRKFDEKNGTWLFNISRGIDLEAVTPRFYSKS 333
            ||:.||||.|..:.|||.::.||.:.:||...|::.|.:|.|.||:::.|||:.|.|.||...||
Zfish   253 KIRNLGGKLGSSITETLSVENMGDLTRFSRAQLEQHFGDKTGPWLYDLCRGIEFEPVKPRQLPKS 317

  Fly   334 IGCCKKFPGRNNITGLKTLQHWLGELSSEINDRLEKDFIENNRRAKHMVVQYVQDIDGEEVAS-S 397
            |||.|.|.|:..:...:.:|:||.:|:.|:.:||.||...|.|.|:.:.|. |:...|:...| |
Zfish   318 IGCSKNFAGKTCLRTKQQVQYWLHQLALELEERLNKDRDVNGRVARQLTVG-VRQAGGQRSGSFS 381

  Fly   398 RSTALRDYDQESIVRLSLDLIKA-NTKTFLRPGSESALNNAIKFLGISVGKFETVSSGQNKLQEM 461
            |..||..||...:...||.:||: ||    ....:.|.:.|:..|.:|..||....|..:.....
Zfish   382 RCCALVRYDAMKMTNDSLTIIKSLNT----AGAHQEAWSPALTLLHLSASKFSDAPSSSSAGITG 442

  Fly   462 F--------ANQAAKKRRVSGDEPGQLPKVEMEKKQKQTDEFKMKSFFANYLQGAKKEDAKADGI 518
            |        .:|::..:|...:.|.|..|.:.:::|:: :...:.:||..  :..:|::.:....
Zfish   443 FLSSDAASSPSQSSSSQRSPMERPAQKRKRQQDQRQRE-NTTSISAFFQR--KSLEKQEIQNSLC 504

  Fly   519 SANPLAAAAGAPNKNFVEEYKHKLHAAVRTEGTVLTSTPAEFKESFFSQYLKQQKKTGQQGSVTS 583
            ..:...:|:|.             ||...|         |..|.:..|.:|::
Zfish   505 PGDQSTSASGE-------------HACGDT---------AAQKTTAISTFLQR------------ 535

  Fly   584 REDSLDVQELAEELDAIEADNSKDFEEDTEEETELTSDTHMSKPEG-----QSSDAGQEQDPNTL 643
              :||:.||: :.:...:.|.|....|:         :|...||.|     |.....:.|..|:|
Zfish   536 --ESLEKQEI-QNVSLDDEDQSVCAPEE---------NTCREKPAGISTSLQMKSLEKHQIQNSL 588

  Fly   644 NDSTGNDLYVETGIVPPTLTEDELKPSTSKRKFDEIESSVSNYKECYVEFAVPNLRTDILPTIKC 708
              ..|:......|..||       :..||    ||..:.:|::
Zfish   589 --CVGDQSVRAPGENPP-------REQTS----DESPAGISSF---------------------- 618

  Fly   709 DQCGANIPDEVKSLQTHRDHHFAQELSRTLRS-TEREERTQSRQKISLKPTPPKKSKKTAG-SGS 771
                    .::|||:.||..:........:|: .|...|.|:.:            :.|:| ||.
Zfish   619 --------FQMKSLEKHRIQNSPCTGDPNIRAPAENTSRDQTSE------------RSTSGMSGC 663

  Fly   772 SSYSTAPPSNSITKFFRAKPTQEQAPSDPQMNQCPECKAFIKCVDMPEHLDYHVARNLQRELNQQ 836
            ...:.||....:.           :|::..:..|..|...:...:.|||.|||.|.:||:..:..
Zfish   664 FQQAVAPAGERVC-----------SPAEEDLQVCERCGMKVLVWEFPEHADYHFALDLQKSFSSG 717

  Fly   837 DLRTRTAALNKEKISPVQPKKQSQKKLNSTISASSSGTKTIAQFFSQS 884
                          ||.|.|..|..:..........|  |:..||.::
Zfish   718 --------------SPSQMKTPSGSQAKRARVQEPRG--TLHSFFKKT 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolH	NP_649371.2	PolY_Pol_eta	20..447	CDD:176456	179/434 (41%)
		zf_UBZ	705..736	CDD:465769	5/30 (17%)
		zf_UBZ	805..832	CDD:465769	11/26 (42%)
polh	NP_001035337.2	PolY_Pol_eta	10..428	CDD:176456	179/435 (41%)
		zf_UBZ	682..712	CDD:465769	10/29 (34%)