Protein Alignment PolH and poli

DIOPT Version :10

• Sequence 1: NP_649371.2
• Gene: PolH / 40438
• FlyBaseID: FBgn0037141
• Length: 885
• Species: Drosophila melanogaster
• Sequence 2: NP_001027479.2
• Gene: poli / 613070
• XenbaseID: XB-GENE-943046
• Length: 742
• Species: Xenopus tropicalis
• Alignment Length: 925
• Identity: 193/925 - (20%)
• Similarity: 344/925 - (37%)
• Gaps: 264/925 - (28%)

  Fly     2 SSARSHVSMQNKYDRVVLLVDMDCFFCQVEEKQHPEYRNRPLAVVQ-YNPWRGGGIIAVNYAARA 65
            |..||..|.    .||::.:|||||:.|||..::||.||:||.:.| |.      ::..||.||.
 Frog    40 SVGRSGTSA----SRVIVHIDMDCFYAQVEMIRNPELRNKPLGIQQKYI------VVTCNYEARK 94

  Fly    66 KGVTRHMRGDEAKDLCPEIVLCQVPNIREKADTSKYRDAGKEVANVLQRFTQLLERASVDEAYLD 130
            .|||:.|...:|::.||::||.      ...|.:.||:.......:|:.|:..:||...||.|:|
 Frog    95 FGVTKLMLIKDAREKCPQLVLV------SGEDLTPYREMSYRATELLEEFSPQVERLGFDENYID 153

  Fly   131 ITETVNHRMQQMQSGAFALQPQELVNTFAVGYPSIGDYVNKITNRFANPYMDDERYQMSYDQNDL 195
            :||.|:.::|:.:...              ..|.:..:|          |.|.:     .:.||
 Frog   154 VTELVDKKLQEERGNG--------------RNPGVCGHV----------YSDQK-----MNVND- 188

  Fly   196 PAVRQSDIRLLIGASVAGEVRAAVKKETGYECSAGIAHNKILAKLAAGMNKPNKQTILPLTETAS 260
                .:.:|:..|:.:|.|:|||:....|....||.|.||:||||.:|.:|||:||.|.....:.
 Frog   189 ----WAHVRIAAGSHIASEIRAALYNRLGLTGCAGTASNKLLAKLVSGTHKPNQQTALLHESHSH 249

  Fly   261 LFDSLP-VGKIKGLGGKFGEVVCETLGIKFMGQVVKFSEVDLQRKFDEKNGTWLFNISRGIDLEA 324
            |.:||. |.:|.|:|.|..:.: |:||:..:..:.......|:::|.......:..:|||.|..|
 Frog   250 LINSLDHVKRIPGIGYKTSKRL-ESLGLSRISDLQACPITLLEKEFGSSVAHRIQMLSRGEDDSA 313

  Fly   325 VTPRFYSKSIGCCKKFPGRNNITGLKTLQHWLGELSSEINDRLEKDFIENNRRAKHMVVQYVQDI 389
            |.|....:||.....|...:.:              ||:..::|:       |.::::|:..:
 Frog   314 VVPSGPPQSISDEDSFKKCSTV--------------SEVKIKMEE-------RLRNLLVRISK-- 355

  Fly   390 DGEEVASSRSTALRDYDQESIVRLSLDLIKANTKTFLRPGSESALNNAIKFLGISVG-KFETVSS 453
            ||.              ....:||::.....:.|.|.|...:..:.   ..:..::| :.:.|.:
 Frog   356 DGR--------------IPHTLRLTIRQFSPSNKWFNRESRQCPIP---AHISQNIGAECQAVPA 403

  Fly   454 GQNKLQEMFANQAAKKRRVSGDEPGQLPKVEME-------------KKQKQTDEFKMKSFFANYL 505
            ....|..:|.               ::..|:|:             |....|     :|....||
 Frog   404 LMELLMRLFE---------------KMIDVKMQFHLTLLNVCFSNLKASNST-----RSSIGFYL 448

  Fly   506 QGAKKEDAKADGISANPLAAAAGAPN---KNF-VEEYKHKLHAAVRTEG-----------TVLTS 555
                  ..||...:|.||..:..|..   ::| ::|.....|.|.::.|           |:|.:
 Frog   449 ------TLKAPPAAATPLKGSTEAEQHTAESFPLKENSSAPHTAPQSVGQPTAPVPTNHHTMLET 507

  Fly   556 TPAEFKESFFSQY---LKQQKKTGQQGSVTSREDSLDVQELAEELDAIEADNSKDFEEDTEEETE 617
            .|.......|||.   ::|:...||:.:..|...|:                            .
 Frog   508 LPEGIDPEVFSQLPEEIQQEIIAGQRHAAASSSSSV----------------------------R 544

  Fly   618 LTSDTHMSKPEG--------QSSDAGQEQDPNTLNDSTGNDLYVETGIVPPTLTEDELKPSTSKR 674
            ..|.:..:.|:|        :::|...:.|...|.:.:                      .|::.
 Frog   545 SASKSQAAPPKGILNFFSRAKAADLPSQCDGVLLKEHS----------------------QTNRG 587

  Fly   675 KFDEIESSVSNYKECYVEFAVPNLRTDILPTIKCDQCGANIPDEVKSLQTHRDHHFAQELSRTLR 739
            ..:..:.:.||:         |....|:.||       .::.|..:.:     |.|.|..
 Frog   588 STEAPQGASSNF---------PKGVVDVRPT-------GSLWDPKQEM-----HPFGQSY----- 626

  Fly   740 STEREERTQSRQKISLKPTPPKKSKKTAGSGSSSYSTAPPSNSITKFFRAKPTQEQAPSDPQMNQ 804
                 :..||.::......|    ..:..|.|:|....||.::..:..:|...||:||
 Frog   627 -----DTDQSAERCGTTAEP----MDSCCSSSTSCGQLPPQSAEMECAKAGGDQERAP------- 675

  Fly   805 CPECKAFIKCVDMPEHLDYHVARNLQRELNQQDLRTRTAALNKEKISPVQPKKQSQKKLNSTISA 869
                        .|..:|.:|...|..|: |::|......|......||:.:.:..|......:.
 Frog   676 ------------FPHSVDVNVFSQLPEEV-QRELMAEWKQLKPTPKIPVRKQSEKAKASRGKRTG 727

  Fly   870 SSSGTKTIAQFFSQS 884
            :|:|..::.::|..|
 Frog   728 ASAGASSLLKYFKPS 742

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolH	NP_649371.2	PolY_Pol_eta	20..447	CDD:176456	110/429 (26%)
		zf_UBZ	705..736	CDD:465769	5/30 (17%)
		zf_UBZ	805..832	CDD:465769	4/26 (15%)
poli	NP_001027479.2	PolY	53..433	CDD:452909	115/481 (24%)
		UBM	509..533	CDD:464159	6/23 (26%)