Protein Alignment PolH and rev1

DIOPT Version :10

• Sequence 1: NP_649371.2
• Gene: PolH / 40438
• FlyBaseID: FBgn0037141
• Length: 885
• Species: Drosophila melanogaster
• Sequence 2: XP_073768289.1
• Gene: rev1 / 570043
• ZFINID: ZDB-GENE-081105-180
• Length: 1284
• Species: Danio rerio
• Alignment Length: 947
• Identity: 185/947 - (19%)
• Similarity: 296/947 - (31%)
• Gaps: 353/947 - (37%)

  Fly    18 VLLVDMDCFFCQVEEKQHPEYRNRPLAVV--------------------QY-------------- 48
            ||.|||||||..|..:..|:...:|:||.                    ||
Zfish   468 VLHVDMDCFFVSVGIRHRPDLIGKPVAVTSNRGPGRVAQRPGANPQLEFQYYQNKQKHYRKEKTD 532

  Fly    49 -------NPWRG----------------GGIIAVNYAARAKGVTRHMRGDEAKDLCPEIVLCQVP 90
                   :|..|                ..|.:.:|.||..||...|....||.|||:  |..||
Zfish   533 GDLEMTPSPQDGEVPSNGVHEDLAALSMAEIASCSYEARQAGVRNGMFFGRAKQLCPD--LQSVP 595

  Fly    91 NIREKADTSKYRDAGKEVANVLQRFTQLLERASVDEAYLDITETVNHRMQQMQSGAFALQPQELV 155
                 .|...|::....:..:|..:|..:|..|.|||.:|.|..:      ::.|   :.|.||
Zfish   596 -----YDFHAYKEVALAMYEILASYTHNIEALSCDEALVDATALL------VELG---VSPDEL- 645

  Fly   156 NTFAVGYPSIGDYVNKITNRFANPYMDDERYQMSYDQNDLPAVRQSDIRLLIGASVAGEVRAAVK 220
                                                                    |..:|..:|
Zfish   646 --------------------------------------------------------ARSIREDIK 654

  Fly   221 KETGYECSAGIAHNKILAKLAAGMNKPNKQTILPLTETASLFDSLPVGKIKGLGGKFGEVVCETL 285
            ::||...|.|::.|.:||::|....||..|.:|...|........||..:.|:|......: .:|
Zfish   655 EKTGCCASVGMSSNILLARMATRKAKPKGQYLLRSEEVDDFIRDQPVSSLPGVGRSMSSKL-TSL 718

  Fly   286 GIKFMGQVVKFSEVDLQRKFDEKNGTWLFNISRGIDLEAVTPRFYSKSIGCCKKFPGRNNITGLK 350
            |:...|.:.:.|...|||:|..:.|..||...||:|...|......||:.....:..|  .|.::
Zfish   719 GVSTCGDLQQLSLSQLQREFGPRTGQTLFRFCRGLDDRPVRSEKERKSVSAEMNYNIR--FTQVE 781

  Fly   351 TLQHWLGELSSEINDRLEKDFIENNRRAKHMVVQYVQDIDGEEVASSRSTALRDYDQESIVRLSL 415
            ..:.:|..||.|:..|||                      |..:...|.|
Zfish   782 EAESFLNNLSMEVQKRLE----------------------GAGLRGRRVT--------------- 809

  Fly   416 DLIKANTKTFLR-PGSESALNNAIKFLGISVGKFETVSSGQNKLQEMFAN-----QAAKKRRVSG 474
                  .|..:| ||:                ..|....|.:.:.:.||.     |.....||..
Zfish   810 ------LKVMMRKPGA----------------PVEPAKYGGHGICDNFARSVLLAQPTDSGRVIA 852

  Fly   475 DEPGQLPKVEMEKKQKQTDEFKMKSFFANYLQGAKKEDAKADGISANPLAAAAGAPNKNFVEEYK 539
            .|..:|              |.........::|...:..:.||..|:|   :...|::.
Zfish   853 SEAIKL--------------FHAMKLNVKDMRGVGLQVQQLDGSHADP---SGQGPSRG------ 894

  Fly   540 HKLHAAVRTEGTVLTSTPAEFKESFFSQYLKQQKKTGQQGSVTSREDSLDVQELAEELDAIEADN 604
                .::|.......|..:..|||                   ..:|.|           |.|.:
Zfish   895 ----RSIRDLLLAKQSAHSPSKES-------------------PSQDGL-----------ISASS 925

  Fly   605 SKDFEEDTEEETELTSDTHMSKPEGQSSDAGQEQDPNTLNDSTGNDLYVETGIVPPTLTEDELKP 669
            |:.|..:.:..|..     :|.|...||.:..                      ||:.|..:..|
Zfish   926 SRAFSSNQKRVTPA-----LSPPPSTSSSSSP----------------------PPSFTIIDPMP 963

  Fly   670 STSKRKFDEIESSVSNYKECYVEFAVPNLRTDILPTIKCDQCGANIPDEVKSLQTHRDHHFAQEL 734
            .|||..:.. ..:.::.:.|.      |:..::....:.|      |..:|:|..        ::
Zfish   964 GTSKGDYHH-PHTPNHVRACL------NISIEVPSPSQVD------PSVLKALPI--------DI 1007

  Fly   735 SRTLRST--EREERTQSRQKISLKPTPPKKSKKTAGSGSSSYSTAPPSNSITKFFRAKPTQEQAP 797
            .|.:..|  .|||:..:....|..|.||              ||.||..|:..         |.|
Zfish  1008 RRQVEETWRYREEQPSTSSHYSTPPRPP--------------STPPPGPSLVL---------QLP 1049

  Fly   798 SDPQMNQCPECKAFIKCVDMPE--HLDYHV----ARNLQREL-----NQQDLRTRTAALNKEKIS 851
            :.|..    .|...| .:::|:  .:|..|    .|.||.||     |:.:.:.:.:.:.::|.|
Zfish  1050 NQPGQ----PCTTGI-ILELPDFSQVDPDVFAALPRELQEELCSAYRNKGNAQAQASTVVEQKNS 1109

  Fly   852 PVQPK-------KQSQKKLNSTISASSSGTKTIAQFF 881
            ..|.|       |:..||.|:  |.:.:|:..:.:.|
Zfish  1110 FPQLKQPAVGKLKRRYKKRNT--SPAKNGSSPLKKMF 1144

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolH	NP_649371.2	PolY_Pol_eta	20..447	CDD:176456	99/484 (20%)
		zf_UBZ	705..736	CDD:465769	4/30 (13%)
		zf_UBZ	805..832	CDD:465769	8/32 (25%)
rev1	XP_073768289.1	None