Protein Alignment PolH and Polh

DIOPT Version :10

• Sequence 1: NP_649371.2
• Gene: PolH / 40438
• FlyBaseID: FBgn0037141
• Length: 885
• Species: Drosophila melanogaster
• Sequence 2: NP_001101674.1
• Gene: Polh / 316235
• RGDID: 1309893
• Length: 689
• Species: Rattus norvegicus
• Alignment Length: 889
• Identity: 269/889 - (30%)
• Similarity: 404/889 - (45%)
• Gaps: 232/889 - (26%)

  Fly    15 DRVVLLVDMDCFFCQVEEKQHPEYRNRPLAVVQYNPWRGGGIIAVNYAARAKGVTRHMRGDEAKD 79
            |.||.||||||||.|||::|:|..||:|.|||||..|:|||||||:|.|||.||||:|..|:||.
  Rat     6 DLVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSYEARAFGVTRNMWADDAKK 70

  Fly    80 LCPEIVLCQVPNIREKADTSKYRDAGKEVANVLQRFTQLLERASVDEAYLDITETVNHRMQQMQS 144
            |||:::|.||...|.||:.:|||:|..||..::..|. ::||||:||||:|:|..|..|::::|.
  Rat    71 LCPDLLLAQVRESRGKANLTKYREASVEVMEIMSHFA-VIERASIDEAYIDLTNAVQERLEKLQG 134

  Fly   145 GAFALQPQE---LVNTFAVGY---PSIGDYVNKITNRFANPYMDDERYQ-----MSYDQNDLPAV 198
                 ||..   |.:|:..|.   |::.|.|.|          :|.|.|     :...:.|.|.
  Rat   135 -----QPVSADLLPSTYIEGLPRGPAVEDTVEK----------EDIRKQGLLQWLGSLEKDDPT- 183

  Fly   199 RQSDIRLLIGASVAGEVRAAVKKETGYECSAGIAHNKILAKLAAGMNKPNKQTILPLTETASLFD 263
             ..|:||.:||.:..|:|||::::||::|||||:|||:|||||.|:||||:||::.......||.
  Rat   184 -SPDLRLTVGAVIVEEMRAAIERKTGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFS 247

  Fly   264 SLPVGKIKGLGGKFGEVVCETLGIKFMGQVVKFSEVDLQRKFDEKNGTWLFNISRGIDLEAVTPR 328
            .:|:.||:.||||.|..|.:.||:::||.:.:|:|..||..|.||||:||:.:.|||:.|.|.||
  Rat   248 QMPIRKIRSLGGKLGASVIDVLGVEYMGDLTQFTEAQLQSHFGEKNGSWLYAMCRGIEHEPVKPR 312

  Fly   329 FYSKSIGCCKKFPGRNNITGLKTLQHWLGELSSEINDRLEKDFIENNRRAKHMVVQYVQDIDGEE 393
            ...|:|||.|.|||:..:...:.:|.||.:|:.|:.:||.||..:|.|.|..:||..  .::|::
  Rat   313 QLPKTIGCSKNFPGKTALATREQVQWWLLQLALELEERLTKDRTDNGRVATQLVVSI--RVEGDK 375

  Fly   394 VASS--RSTALRDYDQESIVRLSLDLIK-ANTKTFLRPGSESALNNAIKFLGISVGKFETVSSGQ 455
            ..||  |..||..||...:.:.:...|: .||.     |.::..:..:..|.:...||...:...
  Rat   376 RLSSLRRCCALTRYDAHKMSQDAFATIRNCNTS-----GVQTEWSPPLTMLFLCATKFSASAPPA 435

  Fly   456 NKLQEMFANQAAKKRRVSGDEPGQLPKVEMEKKQKQTDEFKMKSFFANYLQGAKKEDAKADGISA 520
            .....:|         :|.|. |..|||.......:|.|
  Rat   436 CTDITVF---------LSSDS-GCQPKVPAASSGTRTQE-------------------------- 464

  Fly   521 NPLAAAAGAPNKNFVEEYKHKLHAAVRTEGTVLTSTPAEFKESFFSQYLKQQKKTGQQGSVTSRE 585
                ....||                 |.....||.     ||||.:..|:|:         .||
  Rat   465 ----PGPAAP-----------------TSKEAATSL-----ESFFQKAAKRQR---------MRE 494

  Fly   586 DSLDVQELAEELDAIEADNSKDFEEDTEEETELTSDTHMSKPEGQSSDAGQEQDPNTLNDSTGND 650
            .|....::     |:|..:||                                 |:.|..::|:
  Rat   495 TSFVPPKV-----AVEKSSSK---------------------------------PSLLFQTSGS- 520

  Fly   651 LYVETGIVPPTLTEDELKPSTSKRKFDEIESSVSNYKECYVEFAVPNLRTDILPTIKCDQCGANI 715
                              |.|.           |.:|:          ::.:|...:.....|..
  Rat   521 ------------------PGTK-----------SFFKQ----------KSLLLQHTELSNAAAPC 546

  Fly   716 PDEVKSLQTHRDHHFAQELSRTLRSTEREERTQSRQKISLKPTPPK---KSKKTAGSGSSSYSTA 777
            |.:..|         |.:.||.  .|:|.:...|.::: .||...|   .....||:.|.:|:
  Rat   547 PPQASS---------AVQPSRL--PTDRADSRASCEEV-CKPVSSKAVSTEVNVAGNSSLAYN-- 597

  Fly   778 PPSNSITKFFRAKPTQEQAPSDPQMNQCPECKAFIKCVDMPEHLDYHVARNLQRELNQQDLRTRT 842
              |..:|         ::|..|..:  |.:|.:.:...|||||||||.|..||:...|
  Rat   598 --SQEMT---------QRAAEDQVL--CEKCDSLVPVWDMPEHLDYHFALELQKSFLQ------- 642

  Fly   843 AALNKEKISPVQPKKQSQKKLNSTISASSS-----GTKTIAQFF 881
            ...:|.:..||.|  |.::...|.:::|:.     |.:|:..||
  Rat   643 PCTSKPQAVPVSP--QGKRNPKSPLASSNKRLRPHGMQTLESFF 684

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolH	NP_649371.2	PolY_Pol_eta	20..447	CDD:176456	183/440 (42%)
		zf_UBZ	705..736	CDD:465769	4/30 (13%)
		zf_UBZ	805..832	CDD:465769	14/26 (54%)
Polh	NP_001101674.1	PolY_Pol_eta	10..427	CDD:176456	183/441 (41%)
		zf_UBZ	608..638	CDD:465769	14/31 (45%)